Results 31 to 40 of about 11,223 (224)

Inflammatory cytokines and biofilm production sustain Staphylococcus aureus outgrowth and persistence: A pivotal interplay in the pathogenesis of Atopic Dermatitis [PDF]

, 2018
Individuals with Atopic dermatitis (AD) are highly susceptible to Staphylococcus aureus colonization. However, the mechanisms driving this process as well as the impact of S. aureus in AD pathogenesis are still incompletely understood.
A Matlow, A Oliveira de, A Sandilands, A Sonesson, AC Krakowski, AD Irvine, AM Bowcock, B Cabanillas, B Han, BC Friedman, C Fux, C Pascolini, CI Ewing, CL Jinnestal, D Ellinghaus, D Lebeaux, DY Koller, DYM Leung, DYM Leung, E Clark, E Weinberg, EC Clark, EG Domenico Di, EG Domenico Di, FJ Bath-Hextall, FR Menegotto, G Stinco, GF Gad, GL Hazelbauer, GM O’Regan, GM O’Regan, GU Meduri, H Akiyama, HB Allen, HH Kong, I Marenholz, I Nomura, J Oh, J Schmitt, JH Lee, JM Hanifin, JQ Gong, K Becker, K Breuer, K Krause, KL Hon, L Chronopoulou, L Paternoster, LA O’Neill, LP Girard, M Bhattacharya, M Denis, M Mehrotra, M Niebuhr, MD Howell, ML Schuttelaar, MS Haque, P Castaneda, P Chavant, PH Hoeger, R Lever, R Saginur, RA McLaughlin, RL Gallo, RM Klevens, RP Howlin, S Eriksson, S Kanangat, S Kezic, S Kezic, S Stutte, S Weidinger, SE Hill, SE Satorres, SE Satorres, SH Cho, SH Hung, SJ Gilani, SX Xu, T Bieber, T Biedermann, T Kobayashi, T Nakatsuji, T Werfel, TX Nhan, UG Meduri, V Dossow von, W Abramovits, Z Ikezawa   +88 more
core   +1 more source

Citrullination – small change with a great consequence [PDF]

, 2013
Citrullination is one of the possible post-translational modifications of proteins. It is based on a conversion of L-arginine residue (L-Arg) to L-citrulline residue (L-Cit). The reaction is catalyzed by peptidylarginine deiminases (PAD). The change of L-
Gogól Mariusz
core   +2 more sources

Pathogenic Mechanism of Der p 38 as a Novel Allergen Homologous to RipA and RipB Proteins in Atopic Dermatitis

Frontiers in Immunology, 2021
Atopic dermatitis (AD) is a chronic relapsing pruritic disease encompassing skin inflammation and barrier dysfunction. House dust mites are key allergens that augment the development of atopic dermatitis.
Hyang Jeon, Geunyeong Kim, Ayesha Kashif, Min Hwa Hong, Ji-Sook Lee, Yujin Hong, Beom Seok Park, Eun Ju Yang, In Sik Kim, In Sik Kim   +9 more
doaj   +1 more source

Loss-of-function variants of the filaggrin gene are associated with atopic eczema and associated phenotypes in Swedish families [PDF]

, 2008
Recent studies have identified 2 loss-of-function variants, R501X and 2282del4, in the filaggrin gene as predisposing factors in the development of eczema.
Bradley, Maria, D'Amato, Mauro, Ekelund, Elisabeth, Kockum, Ingrid, Lee, Simon P., Lieden, Agne, Link, Jenny, Palmer, Colin N. A.   +7 more
core   +3 more sources

Filaggrin and tight junction proteins are crucial for IL-13-mediated esophageal barrier dysfunction [PDF]

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2018
Eosinophilic esophagitis (EoE) is an allergy-mediated disease that is accompanied by IL-13 overexpression and an impaired esophageal barrier. Filaggrin (FLG) and tight junction (TJ) proteins are considered to contribute to epithelial barrier function. However, their functional involvement in EoE has not been elucidated. Here, we aimed to determine the
Liping Wu, Tadayuki Oshima, Min Li, Toshihiko Tomita, Hirokazu Fukui, Jiro Watari, Hiroto Miwa   +6 more
openaire   +2 more sources

Genomic, Epigenomic, Transcriptomic, Proteomic and Metabolomic Approaches in Atopic Dermatitis

Current Issues in Molecular Biology, 2023
Atopic dermatitis (AD) is a chronic inflammatory skin disease with a high prevalence in the developed countries. It is associated with atopic and non-atopic diseases, and its close correlation with atopic comorbidities has been genetically demonstrated ...
Dalia Bratu, Daniel Boda, Constantin Caruntu   +2 more
doaj   +1 more source

A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis [PDF]

, 2016
BACKGROUND: Filaggrin, encoded by the FLG gene, is an important component of the skin’s barrier to the external environment and genetic defects in FLG strongly associate with Atopic Dermatitis (AD).
Brown, S, Di, W, Harper, J, Naeem, A, O'Shaughnessy, RFL, Tommasi, C, Way, B, Zhu, Y   +7 more
core   +7 more sources

Diagnostic and prognostic value of antibodies against chimeric fibrin/filaggrin citrullinated synthetic peptides in rheumatoid arthritis [PDF]

, 2009
Introduction: Evidence suggests that citrullinated fibrin(ogen) may be a potential in vivo target of anticitrullinated protein/peptide antibodies (ACPA) in rheumatoid arthritis (RA).
Alejandro Balsa, Eduard Graell, Guadalupe Ercilla, Isabel Haro, Jordi Gratacós, Jose A Gómez-Puerta, Juan D Cañete, Maria J Gómara, Maria L Perez, Marta Larrosa, Odette Viñas, Raimon Sanmartí   +11 more
core   +2 more sources

An Aquaporin 3-Notch1 Axis in Keratinocyte Differentiation and Inflammation [PDF]

, 2013
Aquaporin 3 (AQP3) is an aquaglyceroporin which transports water, glycerol and small solutes across the plasma membrane. Its functions are not limited to fluid transport but also involve the regulation of cell proliferation, migration, skin hydration ...
Chen, Hongxiang, Guo, Liqiong, Li, Yongsheng, Sui, Yang, Zhou, Qixing   +4 more
core   +7 more sources

Early-life regional and temporal variation in filaggrin-derived natural moisturizing factor, filaggrin-processing enzyme activity, corneocyte phenotypes and plasmin activity:Implications for atopic dermatitis [PDF]

, 2018
Background: Filaggrin is central to the pathogenesis of atopic dermatitis (AD). The cheeks are a common initiation site of infantile AD. Regional and temporal expression of levels of filaggrin degradation products [natural moisturizing factors (NMFs ...
Barrett, Bartnikas, Breternitz, Brough, Brown, Carson, Chittock, Clements, Dapic, DeLapp, Fallon, Fluhr, Gibbs, Halkjaer, Hoath, Horimukai, Hsu, Irvine, Kamata, Kamata, Kashibuchi, Kelleher, Kennedy, Kuroda, Ludriksone, McAleer, Mohammed, Mohammed, Raj, Raj, Rawlings, Sandilands, Sandilands, Schwartz, Scott, Simpson, Stamatas, Stamatas, Strid, Strid, Tagami, Takahashi, Takeda, Takeda, Visscher, Voegeli, Voegeli, Weidinger, Yamamoto, Yamazaki   +49 more
core   +3 more sources