Results 41 to 50 of about 11,223 (224)

Refined Immunochemical Characterization in Healthy Dog Skin of the Epidermal Cornification Proteins, Filaggrin, and Corneodesmosin [PDF]

Journal of Histochemistry & Cytochemistry, 2018
Filaggrin (FLG) and corneodesmosin (CDSN) are two key proteins of the human epidermis. FLG loss-of-function mutations are the strongest genetic risk factors for human atopic dermatitis. Studies of the epidermal distribution of canine FLG and CDSN are limited. Our aim was to better characterize the distribution of FLG and CDSN in canine skin.
Pin, Didier, Pendaries, Valérie, Keita Alassane, Sokhna, Froment, Carine, Amalric, Nicolas, Cadiergues, Marie-Christine, Serre, Guy, Haftek, Marek, Vidémont, Emilie, Simon, Michel   +9 more
openaire   +3 more sources

THE ROLE OF GENETIC POLYMORPHISM OF THE FILAGGRIN PROTEIN WITH ATOPIC MARCH PROGRESSION IN CHILDREN

InterConf, 2021
The aim of the study. To determine the role of genetic polymorphism in the filaggrin gene R501XAA and 2282de4AA at atopic march progression in children. Materials and methods. 111 children aged 3 to 12 years with atopic dermatitis were selected and examined.
Stoieva, T. V., Reshetilo, O. V., Vesilyk, N. L., Portnova, O. O., Fedin, M. V., Larionov, O. P.   +5 more
openaire   +2 more sources

RETRACTED ARTICLE: Topical bismuth oxide-manganese composite nanospheres alleviate atopic dermatitis-like inflammation

Journal of Nanobiotechnology, 2023
Atopic dermatitis (AD) is a common skin disease involving important immune mechanisms. There is an unmet need for a treatment for this condition. Herein, we focused on elucidating the role of Bi2-xMnxO3 nanospheres (BM) in alleviating skin inflammation ...
Mengjie Li, Benjin Chen, Lingling Xu, Yu Wang, Zhu Chen, Bingyan Ma, Shichun Qin, Yechun Jiang, Cheng Gu, Haisheng Qian, Fengli Xiao   +10 more
doaj   +1 more source

Epidermal Immunity and Function: Origin in Neonatal Skin

Frontiers in Molecular Biosciences, 2022
The fascinating story of epidermal immunity begins in utero where the epidermal barrier derives from the ectoderm and evolves through carefully orchestrated biological processes, including periderm formation, keratinocyte differentiation, proliferation ...
Marty O. Visscher, Andrew N. Carr, Vivek Narendran   +2 more
doaj   +1 more source

PDE4 inhibition by difamilast regulates filaggrin and loricrin expression via keratinocyte proline-rich protein in human keratinocytes

Journal of Dermatological Science, 2023
Difamilast, a topical phosphodiesterase 4 (PDE4) inhibitor, has been shown to be effective for treating atopic dermatitis (AD), but the molecular mechanism involved is unclear. Since skin barrier dysfunction including reduced expression of filaggrin (FLG) and loricrin (LOR) contributes to AD development, difamilast treatment may be able to improve this
Gaku, Tsuji, Akiko, Hashimoto-Hachiya, Ayako, Yumine, Masaki, Takemura, Makiko, Kido-Nakahara, Takamichi, Ito, Kazuhiko, Yamamura, Takeshi, Nakahara   +7 more
openaire   +2 more sources

Evolutionary diversification of epidermal barrier genes in amphibians

Scientific Reports, 2022
The epidermal differentiation complex (EDC) is a cluster of genes encoding components of the skin barrier in terrestrial vertebrates. EDC genes can be categorized as S100 fused-type protein (SFTP) genes such as filaggrin, which contain two coding exons ...
Attila Placido Sachslehner, Leopold Eckhart   +1 more
doaj   +1 more source

Evolutionary origin and diversification of epidermal barrier proteins in amniotes. [PDF]

, 2014
The evolution of amniotes has involved major molecular innovations in the epidermis. In particular, distinct structural proteins that undergo covalent cross-linking during cornification of keratinocytes facilitate the formation of mechanically resilient ...
Alibardi, Lorenzo, Eckhart, Leopold, Eigenheer, Richard A, Hermann, Marcela, Mlitz, Veronika, Rice, Robert H, Strasser, Bettina, Tschachler, Erwin   +7 more
core   +1 more source

Filaggrin-deficient mice exhibit TH17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen [PDF]

Journal of Allergy and Clinical Immunology, 2009
Filaggrin is important for skin barrier function and is mutated in 15% to 20% of patients with atopic dermatitis.To examine whether filaggrin deficiency predisposes to skin inflammation and epicutaneous sensitization with protein antigen.Skin histology in filaggrin-deficient flaky tail (ft)/ft mice and wild-type controls was assessed by Hematoxylin and
Michiko K, Oyoshi, George F, Murphy, Raif S, Geha   +2 more
openaire   +2 more sources

Skin barrier in atopic dermatitis: beyond filaggrin [PDF]

Anais Brasileiros de Dermatologia, 2016
: Atopic dermatitis is a chronic inflammatory skin disease with a complex pathogenesis, where changes in skin barrier and imbalance of the immune system are relevant factors.
Mariana Colombini Zaniboni, Luciana Paula Samorano, Raquel Leão Orfali, Valéria Aoki   +3 more
doaj   +1 more source

Human and computational models of atopic dermatitis:A review and perspectives by an expert panel of the International Eczema Council [PDF]

, 2018
Atopic dermatitis (AD) is a prevalent disease worldwide and is associated with systemic comorbidities representing a significant burden on patients, their families, and society. Therapeutic options for AD remain limited, in part because of a lack of well-
Bieber, Thomas, Bissonette, Robert, Brown, Sara J., Dhar, Sandipan, Eyerich, Kilian, Guttman-Yassky, Emma, Hijnen, Dirk J., Irvine, Alan, Paller, Amy S., Perez White, Bethany E., Reynolds, Nick J., Tanaka, Reiko J., Thyssen, Jacob P., Vestergaard, Christian, Werfel, Thomas, Wollenberg, Andreas   +15 more
core   +5 more sources