Results 61 to 70 of about 11,223 (224)

Bridging Psychological Stress and Skin Cellular Aging: Flavonoids as a Dual‐Action Therapeutic Strategy

Phytotherapy Research, EarlyView.
ABSTRACT Psychological stress (or simply “stress”) is a major contributor to chronic disease worldwide, affecting 35% of the global population, including younger generations. Furthermore, it plays a significant role in human premature aging; hence, its detrimental effects on people's health compel us to comprehend and control the ways in which ...
Marco Duarte, Sílvia Santos Pedrosa, P. Raaj Khusial, Ana Raquel Madureira   +3 more
wiley   +1 more source

The role of structural skin proteins in the development of atopic dermatitis: A review

Consilium Medicum
Atopic dermatitis (AtD) is a chronic inflammatory skin disease that significantly reduces the quality of life. The underlying factors in the pathogenesis of AtD are dysfunction of the epidermal barrier and impaired immune regulation.
Julia A. Kandrashkina, Ekaterina A. Orlova   +1 more
doaj   +1 more source

Clumping factor B promotes adherence of Staphylococcus aureus to corneocytes in atopic dermatitis [PDF]

, 2017
Staphylococcus aureus skin infection is a frequent and recurrent problem in children with the common inflammatory skin disease atopic dermatitis (AD). S. aureus colonizes the skin of the majority of children with AD and exacerbates the disease. The first
Bennett, Désirée E., Dufrêne, Yves, Fallon, Padraic G., Feuillie, Cécile, Fleury, Orla M., Formosa, Cécile, Foster, Timothy J., Freitag, Nancy E., Geoghegan, Joan A., Irvine, Alan D., Kezic, Sanja, McAleer, Maeve A., McLean, W. H. Irwin, Robinson, D. Ashley, Sansevere, Emily, Towell, Aisling M.   +15 more
core   +4 more sources

Sequence of Immunological Events During IgE‐Mediated Allergic Reactions to Food

Allergy, EarlyView.
ABSTRACT Food allergies (FA) represent a significant global health burden. Upon allergen re‐exposure, allergic patients exhibit a sequence of symptoms that vary in terms of affected organ systems, severity, time of onset and allergen reactivity thresholds.
N. A. Nagy, D. Schnoegl, V. Houghton, L. O'Mahony, A. F. Santos, E. F. Knol, A. Kuehn, T. Eiwegger   +7 more
wiley   +1 more source

The role of interleukin-24 in atopic dermatitis

Exploration of Immunology, 2021
Atopic dermatitis (AD) is characterized by skin barrier disruption, type 2 immune dysregulation, chronic pruritus, and abnormal colonization by Staphylococcus aureus (S. aureus). Tapinarof, an aryl hydrocarbon receptor modulator, has been demonstrated to
Yen Hai Vu, Masutaka Furue, Gaku Tsuji
doaj   +1 more source

Knock-down of filaggrin influences the mitogen-activated protein kinases signaling pathway in normal human epidermal keratinocytes [PDF]

médecine/sciences, 2018
Background: Filaggrin is an essential structural protein of the stratum corneum binding to the keratin intermediate filaments to form a dense protein-lipid matrix. However, the function of filaggrin in epidermal terminal differentiation is not completely understood.
Shumei, Wang, Liyun, Qiu, Xianguang, Meng, Ningning, Dang   +3 more
openaire   +2 more sources

Integrated Clinical Trial and Molecular Profiling Reveals Immune Drivers of Chronic Hand Eczema

Allergy, EarlyView.
This study performed an unbiased molecular profiling of CHE patients across diverse etiologies to identify shared pathogenic drivers and evaluate the impact of IL‐4Rα blockade via dupilumab over 16 weeks. CHE shows a mixed immune signature involving type 1, 2, and 3 pathways with features of atopic dermatitis and psoriasis.
Perrine Gery, Rüçhan Ekren, Emilie Bérard, Aurélie Du‐Thanh, Hugo Rimet, Fatma Jendoubi, Vanina Lenief, Nadia Raison‐Peyron, Amel Bouznad, Maria P. Konstantinou, Jonathan Rioual, Lilian Basso, Juliette Mouiren, Manon Boussier, Brigitte Milpied, Cristina Bulai Livideanu, Louise Jaulent, Florence Hacard, Marine A. Lefevre, Audrey Nosbaum, Julien Seneschal, Marc Vocanson, Carle Paul, Nicolas Gaudenzio, Marie Tauber, on behalf of the French Atopic Dermatitis Network from de GREAT Research group   +25 more
wiley   +1 more source

Exploring Genetic Variants in Epidermal Differentiation Complex Genes in Severe Atopic Dermatitis: A Case Series

Central Asian Journal of Medical Sciences
Objective: The complex interplay between genetic and external factors contributes to the multifactorial nature of atopic dermatitis (AD). The study aimed to use next-generation sequencing (NGS) to identify and describe genetic alterations and ...
Lkhamdari Batbileg, Sevjidmaa Baasanjav, Khosbayar Tulgaa, Khurelbaatar Nyamdavaa, Enkhtur Yadamsuren, Baasanjargal Biziya   +5 more
doaj   +1 more source

Interleukin-22 and keratinocytes; pathogenic implications in skin inflammation

Exploration of Immunology, 2021
Interleukin (IL)-22 is produced from immune cells such as T helper (Th)22 cells, Th17/22 cells, and group 3 innate lymphoid cells. IL-22 signals via the IL-22 receptor 1 (IL-22R1) and the IL-10 receptor 2 (IL-10R2).
Masutaka Furue, Mihoko Furue
doaj   +1 more source

Physical Characteristics of a Citrullinated Pro-Filaggrin Epitope Recognized by Anti-Citrullinated Protein Antibodies in Rheumatoid Arthritis Sera [PDF]

PLOS ONE, 2016
Rheumatoid arthritis (RA) is an autoimmune disease of complex etiology. A characteristic feature of a subset of RA is the presence of anti-citrullinated protein antibodies (ACPA), which correlate with a progressive disease course. In this study, we employed streptavidin capture enzyme-linked immunosorbent assay to analyze ACPA reactivity. Using the pro-
Trier, Nicole Hartwig, Holm, Bettina Eide, Slot, Ole, Locht, Henning, Lindegaard, Hanne, Svendsen, Anders Jørgen, Houen, Gunnar   +6 more
openaire   +4 more sources