Results 11 to 20 of about 4,558 (162)
Persistence and Organ Tropism of Filoviruses in Farmed European Perch (Perca fluviatilis). [PDF]
J Fish DisJournal of Fish Diseases, Volume 49, Issue 5, May 2026.
Perschthaler J +4 more
europepmc +2 more sources
Small Molecule Inhibition of Mononegavirales RNA Polymerases. [PDF]
J Med VirolABSTRACT The order Mononegavirales includes several non‐segmented negative‐sense RNA viruses that are significant human pathogens, whose transcription and replication depend on multifunctional RNA‐dependent RNA polymerase (L protein). Recent discoveries in cryo‐electron microscopy (cryo‐EM) have elucidated the structures of these polymerases and their ...
Cao CR, Mohammed M, Yang G, Wang D.
europepmc +2 more sources
Strategic Preparedness of Broad-Spectrum Antivirals for Rapid Response Towards Next Pandemics. [PDF]
Small SciNanoengineered broad‐spectrum antivirals (BSAs) represent a transformative approach to pandemic preparedness. Unlike virus‐specific drugs requiring separate development, BSAs act across multiple viral families through nanoengineering strategies that enhance solubility, bioavailability, and host‐targeted activity.
N SR, Jin GW, Choy JH.
europepmc +2 more sources
Differences in cynomolgus macaque populations used for infectious disease research. [PDF]
Animal Model Exp MedCynomolgus macaques, a species of Old World primate native to southeastern and eastern Asia and the island of Mauritius, are one of the most important nonhuman primate models for infectious disease. Research into the population genetics of cynomolgus macaques has found significant differences between macaques native to different areas, particularly ...
Quist D +4 more
europepmc +2 more sources
Viruses, 2018 Angola variant (MARV/Ang) has replaced Mt. Elgon variant Musoke isolate (MARV/MtE-Mus) as the consensus standard variant for Marburg virus research and is regarded as causing a more aggressive phenotype of disease in animal models; however, there is a ...
Paul W. Blair +9 more
doaj +1 more source
Viruses of the Filoviridae family
Science and Innovations, 2023 The article considers representatives of the Filoviridae family, some of which are the causative agents of hemorrhagic fever, which is fatal to humans. The current state of development of immunobiological drugs for the treatment and medical prevention of diseases caused by filoviruses has been analyzed.
A. Chernykh, A. Hancharou
openaire +1 more source
Virus specific antibody - based remedies for the urgent prevention and treatment of Ebola virus disease [PDF]
Терапевтический архив, 2019 The Ebola virus (member of Ebolavirus genus Filoviridae family) is the etiologic agent of extremely hazard human disease with high mortality rates (up to 90%). The most important components of spectrum of therapeutics for special prophylactic and current
T E Sizikova +2 more
doaj +1 more source
ICTV Virus Taxonomy Profile: Filoviridae [PDF]
Journal of General Virology, 2019 Members of the family Filoviridae produce variously shaped, often filamentous, enveloped virions containing linear non-segmented, negative-sense RNA genomes of 15–19 kb. Several filoviruses (e.g., Ebola virus) are pathogenic for humans and are highly virulent.
Kuhn, Jens H +23 more
openaire +3 more sources
The Glycoproteins of All Filovirus Species Use the Same Host Factors for Entry into Bat and Human Cells but Entry Efficiency Is Species Dependent. [PDF]
PLoS ONE, 2016 Ebola and marburgviruses, members of the family Filoviridae, can cause severe hemorrhagic fever in humans. The ongoing Ebola virus (EBOV) disease epidemic in Western Africa claimed more than 11,300 lives and was associated with secondary cases outside ...
Markus Hoffmann +4 more
doaj +1 more source
Filoviridae: Insights into Immune Responses to Ebolavirus
SSRN Electronic Journal, 2023 Ebola virus is a zoonotic virus comprised of 6 different species designated within the family Filoviridae and genus Ebolavirus. The first recorded outbreak of an Ebola virus (EBOV) was in Yambuku, Zaire (ZEBOV) in 1976, followed by Sudan Ebola virus (SUBOV) later that year. Outbreaks have been increasing throughout the 21st century, and mortality rates
Brent Brown +4 more
openaire +2 more sources