Exploratory Temporal and Evolutionary Insights into the Filoviridae Family Through Multiprotein Phylogeny [PDF]
MicroorganismsFiloviruses are among the most lethal viral human pathogens known, with significant relevance to public health, yet their evolutionary history remains poorly resolved.
Thiago S. Messias +15 more
doaj +5 more sources
Filoviridae: insights into immune responses to Ebola virus
Exploration of ImmunologyEbola virus (EBOV) is a zoonotic virus comprising of six known different species, designated within the family Filoviridae and genus Ebolavirus. The first recorded outbreak of an EBOV disease (EVD) was in Yambuku, Zaire EBOV (ZEBOV) in 1976, followed by ...
Ingo Fricke +2 more
exaly +4 more sources
ICTV Virus Taxonomy Profile: Filoviridae 2024 [PDF]
Journal of General VirologyFiloviridae is a family of negative-sense RNA viruses with genomes of about 13.1–20.9 kb that infect fish, mammals and reptiles. The filovirid genome is a linear, non-segmented RNA with five canonical open reading frames (ORFs) that encode a nucleoprotein (NP), a polymerase cofactor (VP35), a glycoprotein (GP
Adam J Hume, Elke Műhlberger
exaly +4 more sources
Ebola virus disease: A persistent challenge in global health security [PDF]
Open Veterinary JournalEbola Virus Disease (EVD) is a highly fatal zoonotic disease caused by a negative-stranded RNA virus of the genus Ebolavirus in the family Filoviridae. Since its first discovery in 1976 in Central Africa, the disease has triggered several large outbreaks
Muniroh Muniroh +11 more
doaj +2 more sources
Persistence and Organ Tropism of Filoviruses in Farmed European Perch (Perca fluviatilis) [PDF]
J Fish DisJournal of Fish Diseases, Volume 49, Issue 5, May 2026.
Johanna Perschthaler +4 more
wiley +2 more sources
Viral diversity in wild rodents in the regions of Canaã de Carajás and Curionopólis, State of Pará, Brazil [PDF]
Frontiers in MicrobiologyWild rodents serve as crucial reservoirs for zoonotic viruses. Anthropogenic and environmental disruptions, particularly those induced by mining activities, can destabilize rodent populations and facilitate the emergence of viral agents. In the Canaã dos
Adriana Freitas Moraes Monteiro +12 more
doaj +2 more sources
Development of a Pan-Filoviridae SYBR Green qPCR Assay for Biosurveillance Studies in Bats
Viruses, 2023 Recent studies have indicated that bats are hosts to diverse filoviruses. Currently, no pan-filovirus molecular assays are available that have been evaluated for the detection of all mammalian filoviruses.
Jessica Coertse +5 more
doaj +5 more sources
Small Molecule Inhibition of Mononegavirales RNA Polymerases [PDF]
Journal of Medical Virology, Volume 98, Issue 5, May 2026.ABSTRACT The order Mononegavirales includes several non‐segmented negative‐sense RNA viruses that are significant human pathogens, whose transcription and replication depend on multifunctional RNA‐dependent RNA polymerase (L protein). Recent discoveries in cryo‐electron microscopy (cryo‐EM) have elucidated the structures of these polymerases and their ...
Claire R. Cao +3 more
wiley +2 more sources
Strategic Preparedness of Broad‐Spectrum Antivirals for Rapid Response Towards Next Pandemics [PDF]
Small Science, Volume 6, Issue 1, January 2026.Nanoengineered broad‐spectrum antivirals (BSAs) represent a transformative approach to pandemic preparedness. Unlike virus‐specific drugs requiring separate development, BSAs act across multiple viral families through nanoengineering strategies that enhance solubility, bioavailability, and host‐targeted activity.
Sanoj Rejinold N +2 more
wiley +2 more sources
Genomic Insights into Marburg Virus Strains from 2023 and 2025 Outbreaks in Kagera, Tanzania [PDF]
Emerging Infectious DiseasesMarburg virus (MARV) is the primary cause of Marburg virus disease (MVD), a severe hemorrhagic fever with a high case-fatality rate. The first reported MVD outbreak in Tanzania occurred in 2023, followed by a second outbreak in 2025, both within the ...
Lawrence A. Mapunda +45 more
doaj +2 more sources