Results 91 to 100 of about 6,852 (197)

Diverse hosts, diverse immune systems: Evolutionary variation in bat immunology

Annals of the New York Academy of Sciences, Volume 1550, Issue 1, Page 151-172, August 2025.
Bats are recognized to have distinct immune systems from other vertebrates that may allow them to host virulent pathogens without showing disease. However, these flying mammals are also incredibly diverse, such that bats should not be expected to be immunologically homogenous.
Daniel J. Becker, Amanda Vicente‐Santos, Ashley B. Reers, B. R. Ansil, Mika O'Shea, Caroline A. Cummings, Alicia J. Roistacher, Rita M. Quintela‐Tizon, Manuela M. T. Pereira, Juniper Rosen, Arinjay Banerjee, Hannah K. Frank   +11 more
wiley   +1 more source

Prevalence of human filovirus infections in sub-Saharan Africa: A systematic review and meta-analysis protocol

Systematic Reviews
Recent outbreaks of Ebola virus disease (EVD) and Marburg virus disease (MVD) in sub-Saharan Africa illustrate the need to better understand animal reservoirs, burden of disease, and human transmission of filoviruses.
Christopher S Semancik, Christopher L. Cooper, T. Postler, Matt A. Price, Heejin Yun, Marija Zaric, Monica Kuteesa, Nina Malkevich, Andrew Kilianski, Swati B. Gupta, Suzanna C. Francis   +10 more
semanticscholar   +1 more source

Exploring Therapeutic Targets From Spreading Patterns Against Respiratory Syncytial Virus

The FASEB Journal, Volume 39, Issue 14, 31 July 2025.
RSV spreads through three main modes of infection: receptor‐dependent infection of free viral particles, syncytia formation, and transmission via actin filaments. CX3CR1, CCR3, and HSPG mediate viral adsorption; the IGF1R signaling pathway facilitates viral internalization by recruiting NCL to the membrane surface, and the RHO GTPase and PI3K signaling
Han Zhang, Zhao Zhang, Yixuan Yang, Jingjing Pei   +3 more
wiley   +1 more source

Animal models for filovirus infections.

Zoological research, 2018
The family Filoviridae, which includes the genera Marburgvirus and Ebolavirus, contains some of the most pathogenic viruses in humans and non-human primates (NHPs), causing severe hemorrhagic fevers with high fatality rates. Small animal models against filoviruses using mice, guinea pigs, hamsters, and ferrets have been developed with the goal of ...
Siragam, Vinayakumar, Wong, Gary, Qiu, Xiang-Guo   +2 more
openaire   +2 more sources

Possible leap ahead in filovirus therapeutics [PDF]

Cell Research, 2014
In a recent study published in Nature, Warren et al. describe the generation of a novel synthetic adenosine analogue, BCX4430, a synthetic drug-like small molecule that provides protection from Ebola and Marburg virus infection in animal models.
Darryl, Falzarano, Heinz, Feldmann
openaire   +2 more sources

A Phase 1 randomized trial of homologous and heterologous filovirus vaccines with a late booster dose

npj Vaccines
Filoviruses, including Ebola, Marburg, Sudan, and Taï Forest viruses, are zoonotic pathogens that can cause severe viral hemorrhagic fever and death. Developing vaccines that provide durable, broad immunity against multiple filoviruses is a high global ...
C. Rostad, Inci Yildirim, Carol M Kao, Jumi Yi, S. Kamidani, E. Peters, Kathleen Stephens, Theda Gibson, Hui-Mien Hsiao, Karnail Singh, Paul W. Spearman, Courtney McCracken, Vivien Agbakoba, Kay M. Tomashek, Johannes B. Goll, Casey E Gelber, Robert A. Johnson, Sujin Lee, Kristal M. Maner-Smith, Steven Bosinger, E.A. Ortlund, Xuemin Chen, Larry J. Anderson, J. Wrammert, M. Suthar, Nadine Rouphael, Evan J Anderson   +26 more
semanticscholar   +1 more source

From Bat to Worse: The Pivotal Role of Bats for Viral Zoonosis

Microbial Biotechnology, Volume 18, Issue 7, July 2025.
Thanks to a dampened inflammatory innate immune response, various Chiropteran (bat) species frequently carry ‐ without showing symptoms – diverse viruses that can cause severe diseases in humans. The reasons why bats are a pivotal virus reservoir for emerging viral diseases are discussed in this Lilliput contribution.
Harald Brüssow
wiley   +1 more source

Terpenes and Terpenoids: How can we use them?

European Journal of Organic Chemistry, Volume 28, Issue 24, June 24, 2025.
The transition from petroleum‐based to renewable bio‐based chemicals has led to increased interest in terpenes and terpenoids. This overview highlights their chemistry, focusing on their reactivity and applications in polymerizations, total syntheses, pharmaceuticals, and bio‐based chemical conversions; promoting sustainable and green chemical ...
Jay Hanssens, Diego Meneses, Jordy M. Saya, Romano V. A. Orru   +3 more
wiley   +1 more source

Filovirus RefSeq Entries: Evaluation and Selection of Filovirus Type Variants, Type Sequences, and Names [PDF]

Viruses, 2014
Sequence determination of complete or coding-complete genomes of viruses is becoming common practice for supporting the work of epidemiologists, ecologists, virologists, and taxonomists. Sequencing duration and costs are rapidly decreasing, sequencing hardware is under modification for use by non-experts, and software is constantly being improved to ...
Jens Kuhn, Kristian Andersen, Yīmíng Bào, Sina Bavari, Stephan Becker, Richard Bennett, Nicholas Bergman, Olga Blinkova, Steven Bradfute, J. Brister, Alexander Bukreyev, Kartik Chandran, Alexander Chepurnov, Robert Davey, Ralf Dietzgen, Norman Doggett, Olga Dolnik, John Dye, Sven Enterlein, Paul Fenimore, Pierre Formenty, Alexander Freiberg, Robert Garry, Nicole Garza, Stephen Gire, Jean-Paul Gonzalez, Anthony Griffiths, Christian Happi, Lisa Hensley, Andrew Herbert, Michael Hevey, Thomas Hoenen, Anna Honko, Georgy Ignatyev, Peter Jahrling, Joshua Johnson, Karl Johnson, Jason Kindrachuk, Hans-Dieter Klenk, Gary Kobinger, Tadeusz Kochel, Matthew Lackemeyer, Daniel Lackner, Eric Leroy, Mark Lever, Elke Mühlberger, Sergey Netesov, Gene Olinger, Sunday Omilabu, Gustavo Palacios, Rekha Panchal, Daniel Park, Jean Patterson, Janusz Paweska, Clarence Peters, James Pettitt, Louise Pitt, Sheli Radoshitzky, Elena Ryabchikova, Erica Saphire, Pardis Sabeti, Rachel Sealfon, Aleksandr Shestopalov, Sophie Smither, Nancy Sullivan, Robert Swanepoel, Ayato Takada, Jonathan Towner, Guido Van der Groen, Viktor Volchkov, Valentina Volchkova, Victoria Wahl-Jensen, Travis Warren, Kelly Warfield, Manfred Weidmann, Stuart Nichol   +75 more
openaire   +4 more sources

Host-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies

mBio, 2016
The filovirus surface glycoprotein (GP) mediates viral entry into host cells. Following viral internalization into endosomes, GP is cleaved by host cysteine proteases to expose a receptor-binding site (RBS) that is otherwise hidden from immune ...
Zachary A. Bornholdt, Esther Ndungo, Marnie L. Fusco, Shridhar Bale, Andrew I. Flyak, James E. Crowe, Kartik Chandran, Erica Ollmann Saphire   +7 more
doaj   +1 more source