Results 71 to 80 of about 9,748 (234)
Protein Science, Volume 34, Issue 11, November 2025.Abstract Following the SARS‐CoV‐2 pandemic, many direct‐acting antivirals targeting viral cysteine protease were developed. SARS‐CoV‐2, as well as other viruses, rely on cysteine proteases for their replication, suggesting future generations of antivirals targeting cysteine proteases will emerge.
Zoe Turner +9 more
wiley +1 more source
Emerging virus diseases: can we ever expect the unexpected?
Emerging Microbes and Infections, 2012 Emerging virus diseases are a major threat to human and veterinary public health. With new examples occurring approximately one each year, the majority are viruses originating from an animal host.
Colin R Howard, Nicola F Fletcher
doaj +1 more source
Organoid Models to Study Human Infectious Diseases
Cell Proliferation, Volume 58, Issue 11, November 2025.Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu +4 more
wiley +1 more source
[Disease Caused by Filoviruses: An Update].
Acta Médica PortuguesaThe Marburg and Ebola viruses belong to the Filoviridae family and are known to cause emerging zoonotic diseases. These viruses have a high case fatality rate and are easily transmissible from person to person, which makes them capable of triggering ...
Rafael Marx de Andrade +3 more
semanticscholar +1 more source
Genetics-Based Classification of Filoviruses Calls for Expanded Sampling of Genomic Sequences
Viruses, 2012 We have recently developed a computational approach for hierarchical, genome-based classification of viruses of a family (DEmARC). In DEmARC, virus clusters are delimited objectively by devising a universal family-wide threshold on intra-cluster genetic ...
Alexander E. Gorbalenya, Chris Lauber
doaj +1 more source
Increasing Occurrence of Marburg Virus Outbreaks in Africa: Risk Assessment for Public Health
Microbial Biotechnology, Volume 18, Issue 9, September 2025.Bat and Marburg virus (Filovirus). Left: A Rousettus aegyptiacus bat; Center: a distribution map of R. aegyptiacus; Right: EM of Marburg virus. (figure credits: Left Wikipedia Nilflughund Lithuanian Zoological Gardens, Center; Center: Wikipedia Nilflughund IUCN Red List of Threatened Species, right Wikipedia Marburg virus CDC Fred Murphy; J.
Harald Brüssow
wiley +1 more source
Phylogenetic analysis of the promoter element 2 of paramyxo- and filoviruses
Microbiology spectrumParamyxo- and filovirus genomes are equipped with bipartite promoters at their 3' ends to initiate RNA synthesis. The two elements, the primary promoter element 1 (PE1) and the secondary promoter element 2 (PE2), are separated by a spacer region that ...
Shoichi Ashida +6 more
semanticscholar +1 more source
Endocytic Pathways Involved in Filovirus Entry: Advances, Implications and Future Directions
Viruses, 2012 Detailed knowledge of the host-virus interactions that accompany filovirus entry into cells is expected to identify determinants of viral virulence and host range, and to yield targets for the development of antiviral therapeutics.
Suchita Bhattacharyya +2 more
doaj +1 more source
Human and murine IFIT1 proteins do not restrict infection of negative-sense RNA viruses of the Orthomyxoviridae, Bunyaviridae, and Filoviridae families [PDF]
, 2015 UNLABELLED: Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) is a host protein with reported cell-intrinsic antiviral activity against several RNA viruses.
Amarasinghe, Gaya +12 more
core +3 more sources
The Antiviral Activity of Polyphenols
Molecular Nutrition &Food Research, Volume 69, Issue 15, August 2025.Polyphenols demonstrate remarkable antiviral properties by effectively disrupting multiple biochemical processes essential for viral replication. ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a ...
Markus Burkard +5 more
wiley +1 more source