Results 61 to 70 of about 170,461 (360)

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Fish oil: a panacea?

Biomedicine & Pharmacotherapy, 1990
Since the first report by Bang and Dyerberg regarding the apparent beneficial effects of a fish oil-enriched diet on the incidence of atherosclerotic heart disease in Greenland eskimos, a considerable number of studies have been performed regarding the effects of omega-3 polyunsaturated fatty acids on the prevention and treatment of a variety of ...
R. O. B. Gans, H. J. G. Bilo
openaire   +3 more sources

GLSD: The Global Large-Scale Ship Database and Baseline Evaluations [PDF]

arXiv, 2021
In this paper, we introduce a challenging global large-scale ship database (called GLSD), designed specifically for ship detection tasks. The designed GLSD database includes a total of 212,357 annotated instances from 152,576 images. Based on the collected images, we propose 13 ship categories that widely exist in international routes. These categories
arxiv  

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Fish oils in the prevention of atherosclerosis

Journal of the American College of Cardiology, 1992
The hypothesis that oils derived from the flesh of fish and marine mammals inhibit the atherosclerotic process is critically reviewed. Populations consuming a diet rich in fish have low rates of coronary heart disease. Dietary fish oil is associated with changes in serum lipids, prostaglandin and leukotriene metabolism, enhanced endothelial function ...
Douglas H. Israel, Richard Gorlin
openaire   +3 more sources

How does stock market volatility react to oil shocks? [PDF]

, 2018
We study the impact of oil price shocks on the U.S. stock market volatility. We jointly analyze three different structural oil market shocks (i.e., aggregate demand, oil supply, and oil-specific demand shocks) and stock market volatility using a structural vector autoregressive model.
arxiv   +1 more source

A non‐fluorescent immunohistochemistry method for measuring autophagy flux using MAP1LC3/LC3 and SQSTM1 as core markers

FEBS Open Bio, EarlyView.
We introduce an immunohistochemistry method to measure autophagy flux, highlighting the active degradation and recycling of cellular waste. This cost‐effective approach uses tissue samples to track key markers like LC3 and SQSTM1, revealing how cells maintain health or respond to diseases such as cancer. It bridges the gap between research and clinical
Shahla Shojaei, Amir Barzegar Behrooz, Marco Cordani, Mahmoud Aghaei, Negar Azarpira, Daniel J. Klionsky, Saeid Ghavami   +6 more
wiley   +1 more source

Evaluacion de un producto a base de aceite esencial de oregano sobre la integridad intestinal, la capacidad de absorcion de nutrientes y el comportamiento productivo de pollos de carne [PDF]

arXiv, 2022
Eight experiments were conducted to test an oregano-essential-oil-based product (PRO) on performance, gut health, and nutrient absorption capacity in broilers. The first three, up to 14d and without specific challenges, tested the effects on intestinal histology, skeletal integrity, and growth.
arxiv  

Pengaruh Pemberian Minyak Atsiri Daun Bandotan (Ageratum Conyzoides) Dalam Transportasi Tertutup Benih Ikan Koi (Cyprinus Carpio) [the Effects of Bandotan Leave's (Ageratum Conyzoides) Essential Oil Within Closed System Transportation of Koi Carp (Cyprinus Carpio) ] [PDF]

, 2014
In the ornamental fish business, transportation has an important role to distributing fish up into the costumers. The distance between the farm and the customers location, require a transportation method which can maintain the quality and quantity of ...
Dantika, I. B. (Ida), Sulmartiwi, L. (Laksmi), Triastuti, R. J. (Rr)   +2 more
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