Results 101 to 110 of about 4,417 (197)

Stress-Induced Changes in the Lipid Microenvironment of β-(1,3)-d-Glucan Synthase Cause Clinically Important Echinocandin Resistance in Aspergillus fumigatus

mBio, 2019
Aspergillus fumigatus is a leading cause of invasive fungal infections. Resistance to first-line triazole antifungals has led to therapy with echinocandin drugs. Recently, we identified several high-minimum-effective-concentration (MEC) A.
Shruthi Satish, Cristina Jiménez-Ortigosa, Yanan Zhao, Min Hee Lee, Enriko Dolgov, Thomas Krüger, Steven Park, David W. Denning, Olaf Kniemeyer, Axel A. Brakhage, David S. Perlin   +10 more
doaj   +1 more source

Synergistic in vitro activity of sodium houttuyfonate with fluconazole against clinical Candida albicans strains under planktonic growing conditions

Pharmaceutical Biology, 2017
Context: Fluconazole resistance is an intractable problem of treating Candida albicans, calling for more antifungal agents to enhance the activity of fluconazole. Objective: This work investigates the anti-C.
Jing Shao, YanYan Cui, MengXiang Zhang, TianMing Wang, DaQiang Wu, ChangZhong Wang   +5 more
doaj   +1 more source

Fighting Emerging Caspofungin-Resistant Candida Species: Mitigating Fks1-Mediated Resistance and Enhancing Caspofungin Efficacy by Chitosan

Antibiotics
Invasive candidiasis poses a worldwide threat because of the rising prevalence of antifungal resistance, resulting in higher rates of morbidity and mortality. Additionally, Candida species, which are opportunistic infections, have significant medical and
Aya A Tarek, Yasmine H. Tartor, Mohamed N Hassan, I. Peț, M. Ahmadi, Adel Abdelkhalek   +5 more
semanticscholar   +1 more source

Estado actual de las resistencias de Candida a los fármacos antifúngidos y estudio de los mecanismos implicados [PDF]

, 2018
[ES] El género Candida se encuentra taxonómicamente ubicado dentro del reino Fungi,subreino Dikarya y orden Sacharomycetales (Bonifaz, 2012). Se trata de una levadura redonda u ovalada de 4-6 μm de tamaño denominada blastoconidio, que forma gemaciones ...
Bilbao Bilbao, Nagore
core  

Genome sequence and genetic linkage analysis of Shiitake mushroom _Lentinula edodes_ [PDF]

, 2012
_Lentinula edodes_ (Shiitake/Xianggu) is an important cultivated mushroom. Understanding the genomics and functional genomics of _L. edodes_ allows us to improve its cultivation and quality.
Chun Hang Au, Hoi Shan Kwan, Iris Sze Wai Kwok, Jing Qin, Kin Sing Wong, Lei Li, Man Chun Wong, Pui Ying Yip, Qian Li Huang, Wen Yan Nong, Winnie Wing Yan Chum   +10 more
core   +2 more sources

Enhancing Flucytosine Anticandidal Activity Using PEGylated Squalene Nanocarrier

ChemMedChem, Volume 20, Issue 1, January 2, 2025.
Our study focused on improving the effectiveness of the antifungal drug 5‐fluorocytosine (5FC) by loading it in micellar structures formed by PEGylated squalene copolymer. The obtained results for 5FC‐loaded micelles showed in vitro prolonged release under physiological conditions and improved in vitro antifungal activity without cytotoxicity for ...
Bogdan‐Florin Craciun, Irina Rosca, Dragos Peptanariu, Mariana Pinteala   +3 more
wiley   +1 more source

The Significance of Mono‐ and Dual‐Effective Agents in the Development of New Antifungal Strategies

Chemical Biology &Drug Design, Volume 105, Issue 1, January 2025.
The future of treating challenging fungal infections lies in novel therapies targeting new antifungal targets, overcoming resistance mechanisms, and exploring innovative dual inhibitors. ABSTRACT Invasive fungal infections (IFIs) pose significant challenges in clinical settings, particularly due to their high morbidity and mortality rates.
Cengiz Zobi, Oztekin Algul
wiley   +1 more source

The Candida auris Infection After the COVID‐19 Pandemic Seems to be an Urgent Public Health Emergency: A Call to Attention

Health Science Reports, Volume 7, Issue 11, November 2024.
Abstract Background and Aims Inconsequential diseases can sometimes become extremely dangerous through mutation. Antifungal resistance has increased by 24%, and resistance only due to Candida auris (C. auris) species have increased by 60%. Here, we aimed to assess the knowledge of antifungal treatment and preventative measures to mitigate the ...
Md. Ashrafur Rahman, Evangelos Victoros, Yeasna Shanjana, Marie Roke Thomas, Md. Rabiul Islam   +4 more
wiley   +1 more source

Multicentre Study of Candida parapsilosis Blood Isolates in Türkiye Highlights an Increasing Rate of Fluconazole Resistance and Emergence of Echinocandin and Multidrug Resistance

Mycoses, Volume 67, Issue 11, November 2024.
ABSTRACT Objectives Worldwide emergence of clonal outbreaks caused by fluconazole‐resistant (FLCR) and the recent emergence of echinocandin‐ and multidrug‐resistant (ECR and MDR) Candida parapsilosis isolates pose serious threats to modern clinics.
Nevzat Ünal, Bram Spruijtenburg, Amir Arastehfar, Ramazan Gümral, Theun de Groot, Eelco F. J. Meijer, Hatice Türk‐Dağı, Asuman Birinci, Süleyha Hilmioğlu‐Polat, Jacques F. Meis, Cornelia Lass‐Flörl, Macit Ilkit   +11 more
wiley   +1 more source

Reconstructing phylogenetic level-1 networks from nondense binet and trinet sets [PDF]

, 2014
Binets and trinets are phylogenetic networks with two and three leaves, respectively. Here we consider the problem of deciding if there exists a binary level-1 phylogenetic network displaying a given set T of binary binets or trinets over a taxon set X ...
AV Aho, B Holland, C Choy, C Semple, Celine Scornavacca, D Gusfield, D Huson, DH Huson, E Bapteste, F Pardi, G Cardona, H Poormohammadi, J Jansson, J Jansson, J Jansson, K Strimmer, Katharina T. Huber, KT Huber, KT Huber, KT Huber, Leo van Iersel, LJJ Iersel van, P Gambette, Taoyang Wu, Vincent Moulton, Y Yu   +25 more
core   +6 more sources