Differential Regulation of Echinocandin Targets Fks1 and Fks2 in Candida glabrata by the Post-Transcriptional Regulator Ssd1 [PDF]
Journal of Fungi, 2020 Invasive infections caused by the opportunistic pathogen Candida glabrata are treated with echinocandin antifungals that target β-1,3-glucan synthase, an enzyme critical for fungal cell wall biosynthesis. Echinocandin resistance develops upon mutation of
Kelley R. Healey +7 more
doaj +4 more sources
Do Candida albicans Isolates with Borderline Resistant Micafungin MICs Always Harbor FKS1 Hot Spot Mutations? [PDF]
Journal of Fungi, 2021 Antifungal susceptibility testing is important in guiding patient therapy due to an increasing number of resistant Candida isolates. In the clinical strain collection of the Austrian resistance report (AURES), a high number of micafungin-resistant C ...
Kathrin Spettel +4 more
doaj +4 more sources
Evolutionary accumulation of FKS1 mutations from clinical echinocandin-resistant Candida auris
Emerging Microbes and InfectionsIntroduction: Drug resistance to echinocandins, first-line drugs used to treat Candida auris infection, is rapidly emerging. However, the accumulation of mutations in genes other than FKS1 (before an isolate develops to resistance via FKS1 mutations ...
Sufei Tian +8 more
doaj +4 more sources
Effect of Conformational Variability on the Drug Resistance of Candida auris ERG11p and FKS1
ACS OmegaCandida auris infection has been recognized as an urgent threat to antifungal drug resistance, and the Eagle effect of C. auris FKS1 (1,3-β-d-glucan synthase) wild-type isolates has also been noted.
Hiroshi Izumi +2 more
doaj +4 more sources
Novel FKS1 and FKS2 modifications in a high-level echinocandin resistant clinical isolate of Candida glabrata [PDF]
Emerging Microbes and Infections, 2019 Echinocandin resistance in Candida glabrata poses a serious clinical challenge. The underlying resistance mechanism of a pan-echinocandin-resistant C. glabrata isolate (strain L74) was investigated in this study.
Xin Hou +14 more
doaj +4 more sources
Journal of Global Antimicrobial Resistance, 2020 Objectives: The rate of resistance of Candida parapsilosis to echinocandins remains unexplored in Iran. The main aims of this study were to investigate the susceptibility patterns and possible mechanisms of echinocandin resistance in echinocandin ...
Amirhossein Davari +7 more
doaj +4 more sources
Structural and mechanistic insights into fungal β-1,3-glucan synthase FKS1
Nature, 2023 Using cryo-electron microscopy, the molecular architecture and catalytic mechanism of action of the fungal β-1,3-glucan synthase FKS1 are determined. The membrane-integrated synthase FKS is involved in the biosynthesis of β-1,3-glucan, the core component
Xinlin Hu +9 more
semanticscholar +3 more sources
Novel Non-Hot Spot Modification in Fks1 of Candida auris Confers Echinocandin Resistance
Antimicrobial Agents and Chemotherapy, 2023 We determined the echinocandin susceptibility and FKS1 genotypes of 13 clinical isolates of Candida auris that were recovered from 4 patients at a tertiary care center in Salvador, Brazil.
Milena Kordalewska +6 more
semanticscholar +3 more sources
SCY-247, a novel second-generation triterpenoid antifungal, demonstrates high in vitro activity against genetically diverse Candida auris isolates, including FKS1 mutants. [PDF]
J Antimicrob ChemotherCandida auris (also known as Candidozyma auris ) causes large and persistent outbreaks in healthcare settings and is associated with a high mortality rate in patients with invasive infections.
Spruijtenburg B, de Groot T, Meijer EFJ.
europepmc +2 more sources
Inhibition mechanism of the fungal β−1,3-glucan synthases by triterpenoid antifungal drugs [PDF]
Nature Communicationsβ−1,3-glucan synthase is the molecular target for triterpenoid and echinocandin antifungal drugs in clinical. It catalyzes the formation of β−1,3-glucan, which is the primary component of the fungal cell wall.
Zi-Long You +9 more
doaj +2 more sources