Results 21 to 30 of about 4,417 (197)

In vitro activity of eight antifungal drugs against clinical and hospital isolates of Candida parapsilosis complex; a multicenter study, 2023–2024 [PDF]

BMC Infectious Diseases
Background Candida parapsilosis complex is an emerging opportunistic pathogen associated with bloodstream infections and healthcare‑associated outbreaks, particularly in intensive care units.
Azam Moslemi, Maryam Salimi, Mahdi Abastabar, Reza Valadan, Maryam Moazeni, Mohammad Taghi Hedayati, Seyed Reza Aghili, Leila Faeli, Zoha Asgari, Iman Haghani, Hossein Zarrinfar, Sabah Mayahi, Tahereh Shokohi, Hamid Badali   +13 more
doaj   +2 more sources

546. Transmission of Candida auris FKS1 Mutations in Orange County, CA [PDF]

Open Forum Infect Dis
Background Candida auris (C. auris) is a potentially multidrug-resistant yeast that can cause severe infections in high-risk patient care populations and is endemic in Orange County (OC). U.S.
J. Brown, Mi Le, Denise Tirol, Elizabeth Kryger, Gabrielle Villareal, Cherry Q Fontela, Angelica Torres, Tania Chiem, Victoria Buchanan, Curtis J Kapsak, M. Crumpler, Matthew Zahn   +11 more
europepmc   +2 more sources

FKS1 mutation associated with decreased echinocandin susceptibility of Aspergillus fumigatus following anidulafungin exposure [PDF]

Scientific Reports, 2020
Invasive aspergillosis (IA) is a potentially lethal infection that affects mostly immunocompromised patients caused by Aspergillus fumigatus. Echinocandins are a second-line therapy against IA, used as a salvage therapy as well as for empirical or ...
Ana Pinto e Silva, I. Miranda, Joana Branco, P. Oliveira, I. Faria-Ramos, Raquel M. Silva, A. Rodrigues, S. Costa-de-Oliveira   +7 more
semanticscholar   +3 more sources

Caspofungin resistance in Candia auris due to mutations in Fks1 with adjunctive role of chitin and key cell wall stress response pathway genes [PDF]

Antimicrobial Agents and Chemotherapy, 2020
The emergence of echinocandin resistance in C. auris has become a major concern. Point mutations in Fks1 subunit of β-D-glucan synthase is the primary mechanism in echinocandin resistance.
Dipti Sharma, R. Paul, A. Chakrabarti, S. Bhattacharya, R. Soman, S. Shankarnarayan, D. Chavan, Shreya Singh, P. Das, H. Kaur, Anup K. Ghosh, S. Rudramurthy   +11 more
semanticscholar   +6 more sources

Candida parapsilosis isolates carrying mutations outside of FKS1 hotspot regions confer high echinocandin tolerance and facilitate the development of echinocandin resistance.

International Journal of Antimicrobial Agents, 2023
Candida parapsilosis is one of the significant causes of candidemia worldwide. Although rare, echinocandin-resistant (ECR) and echinocandin-tolerant (ECT) C. parapsilosis isolates have been reported from various countries.
F. Daneshnia, A. Arastehfar, Lisa Lombardi, U. Binder, Jakob Scheler, Roya Vahedi, F. Hagen, C. Lass‐Flörl, Michael K. Mansour, G. Butler, D. Perlin   +10 more
semanticscholar   +4 more sources

Adaptation of the tetracycline-repressible system for modulating the expression of essential genes in Cryptococcus neoformans [PDF]

mSphere
The opportunistic human fungal pathogen Cryptococcus neoformans has an enormous impact on human health as the causative agent of cryptococcal meningitis, and there is a dire need to expand our current antifungal arsenal.
Ci Fu, Nicole Robbins, Leah E. Cowen
doaj   +2 more sources

Emergence of multidrug-resistant Candidozyma auris in southern China: a multicenter study on genetic diversity and antifungal resistance [PDF]

Frontiers in Microbiology
PurposeCandidozyma auris (C. auris) is an emerging fungal pathogen that is resistant to multiple drugs and poses a serious threat to global health. This study aimed to investigate the genetic diversity and antifungal resistance profiles of C.
Penghao Guo, Jingchun Fang, Ruizhi Wang, Weihong Lin, Yueting Jiang, Jun Long, Lingjuan Chen, Xudong Huang, Kang Liao, Yaqin Peng   +9 more
doaj   +2 more sources

Epistasis at the cell surface: what is the role of Erg3 loss-of-function in acquired echinocandin resistance? [PDF]

mBio
Echinocandins, which target the fungal β-1,3-glucan synthase (Fks), are essential for treating invasive fungal infections, yet resistance is increasingly reported.
Hans Carolus, Judith Díaz-García, Vladislav Biriukov, Stef Jacobs, Dimitrios Sofras, Alicia Pageau, Celia Lobo Romero, Lore Vinken, Pilar Escribano, Jesús Guinea, Katrien Lagrou, Christian R. Landry, Toni Gabaldón, Patrick Van Dijck   +13 more
doaj   +2 more sources

Challenging SNP impact on caspofungin resistance by full-length FKS1 allele replacement in Candida lusitaniae

Journal of Antimicrobial Chemotherapy, 2018
OBJECTIVES A strain of the opportunistic pathogenic yeast Candida lusitaniae was genetically engineered for full-length replacement of the FKS1 gene encoding the target of echinocandin antifungals in order to assess the impact of FKS mutations on ...
I. Accoceberry, Célia Couzigou, Valérie Fitton-Ouhabi, N. Biteau, T. Noël   +4 more
semanticscholar   +3 more sources

In vitro evolution of caspofungin resistance in Candidozyma auris via FKS1 hotspot I mutations results in moderate fitness trade-offs but no reduction in virulence

bioRxiv
Resistance to echinocandins in the recently emerged pathogen Candidozyma auris (previously known as Candida auris) poses significant clinical challenges. This study reports the in vitro evolution of a caspofungin-sensitive C.
Ross ZK, Alsayegh S, Zhao Y, Munro CA, Lorenz A.   +4 more
europepmc   +2 more sources