Results 31 to 40 of about 4,417 (197)
Effective treatment of systemic candidiasis by synergistic targeting of cell wall synthesis [PDF]
Nature CommunicationsFungal infections pose a serious threat to global human health fueled by the increase in immunosuppressive therapies, medical implants, and transplantation.
Ju Yeon Chung +7 more
doaj +2 more sources
Quick Detection of FKS1 Mutations Responsible for Clinical Echinocandin Resistance in Candida albicans [PDF]
Journal of Clinical Microbiology, 2015 ABSTRACT A rapid molecular-based assay for the detection of the Candida albicans FKS1 gene mutations responsible for resistance to echinocandin drugs was designed and evaluated. The assay consisted of a multiplexed PCR set of 5 tubes able to detect the most commonly described resistance mechanism ...
Catiana Dudiuk +6 more
semanticscholar +11 more sources
Implication of Candida parapsilosis FKS1 and FKS2 Mutations in Reduced Echinocandin Susceptibility [PDF]
Antimicrobial Agents and Chemotherapy, 2015 ABSTRACT We evaluated FKS1 and FKS2 mutations in Candida parapsilosis bloodstream isolates and correlated them with the echinocandin MIC values determined by guidelines in CLSI document M27-A3 and the YeastOne panel.
M. Martí-Carrizosa +4 more
semanticscholar +6 more sources
Сибирский онкологический журнал, 2022 Relevance. The global trend of rapid increase in resistance to antifungal drugs due to multiple factors, dictates the need for continuous monitoring of taxonomic structure and susceptibility of nosocomial pathogens, causing invasive fungal infections ...
N. S. Bagirova +6 more
doaj +1 more source
Topological and Mutational Analysis of Saccharomyces cerevisiae Fks1 [PDF]
Eukaryotic Cell, 2012 ABSTRACT Fks1, with orthologs in nearly all fungi as well as plants and many protists, plays a central role in fungal cell wall formation as the putative catalytic component of β-1,3-glucan synthase. It is also the target for an important new antifungal group, the echinocandins, as evidenced by the localization of resistance ...
Michael E, Johnson, Thomas D, Edlind
openaire +2 more sources
Echinocandin Failure Case Due to a Previously Unreported FKS1 Mutation in Candida krusei [PDF]
Antimicrobial Agents and Chemotherapy, 2014 ABSTRACT Echinocandins are the preferred therapy for invasive infections due to Candida krusei . We present here a case of clinical failure involving C. krusei with a characteristic FKS1 hot spot mutation not previously reported in C. krusei
R. H. Jensen +4 more
semanticscholar +5 more sources
Phosphatidylinositol (4,5)-bisphosphate turnover by INP51 regulates the cell wall integrity pathway in "Saccharomyces cerevisiae" [PDF]
, 2004 Signal transduction pathways are important for the cell to transduce external or internal stimuli where second messengers play an important role as mediators of the stimuli. One important group of second messengers are the phosphoinositide family present
Morales-Johansson, Helena
core +2 more sources
Pharmaceutics, 2023 Candida auris is a multidrug-resistant pathogen against which echinocandins are the drug of choice. However, information on how the chitin synthase inhibitor nikkomycin Z influences the killing activities of echinocandins against C.
Awid Adnan +9 more
doaj +1 more source
Analysis of molecular resistance to azole and echinocandin in Candida species in patients with vulvovaginal candidiasis [PDF]
Current Medical Mycology, 2022 Background and Purpose: Vulvovaginal candidiasis (VVC) is considered the most common mucosal infection caused by Candida species. Azoles were considered the firstline treatment for VVC or recurrent vulvovaginal candidiasis (RVVC) in both healthy and ...
Ensieh Lotfali +5 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2021 Diutina catenulata (Candida catenulata) is an ascomycete yeast species widely used in environmental and industrial research and capable of causing infections in humans and animals. At present, there are only a few studies on D.
Xin-Fei Chen +37 more
doaj +1 more source