Results 41 to 50 of about 4,417 (197)

KNR4, a suppressor of Saccharomyces cerevisiae cwh mutants, is involved in the transcriptional control of chitin synthase genes [PDF]

, 1999
The KNR4 gene, originally isolated by complementation of a K9 killer-toxinresistant mutant displaying reduced levels of both 1,3-b-glucan and 1,3-bglucan synthase activity, was recloned from a YCp50 genomic library as a suppressor of Saccharomyces ...
Dagkessamanskaia, Adilia, Dallies, Nathalie, Francois, Jean, Martin, Helene, Satchanska, Galina   +4 more
core   +3 more sources

Drug Resistance-Associated Mutations in ERG11 of Multidrug-Resistant Candida auris in a Tertiary Care Hospital of Eastern Saudi Arabia

Journal of Fungi, 2020
Candida auris is an emerging multi-drug resistant pathogen with high mortality rate; nosocomial infections have been reported worldwide, causing a major challenge for clinicians and microbiological laboratories. The study aims to describe new cases of C.
Reem AlJindan, Doaa M. AlEraky, Nehal Mahmoud, Baha Abdalhamid, Mashael Almustafa, Sayed AbdulAzeez, J. Francis Borgio   +6 more
doaj   +1 more source

Set of Classical PCRs for Detection of Mutations in Candida glabrata FKS Genes Linked with Echinocandin Resistance [PDF]

, 2014
Clinical echinocandin resistance among Candida glabrata strains is increasing, especially in the United States. Antifungal susceptibility testing is considered mandatory to guide therapeutic decisions.
Afeltra, Javier, Dudiuk, Catiana Beatriz, Gamarra, Maria Soledad, Garcia, Guillermo Manuel, Jimenez Ortigoza, Cristina, Leonardelli, Florencia, Perlin, David S., Vitale, Roxana Gabriela   +7 more
core   +2 more sources

Fitness and Virulence Costs of Candida albicans FKS1 Hot Spot Mutations Associated With Echinocandin Resistance [PDF]

The Journal of Infectious Diseases, 2011
The identification of FKS1 mutations in Candida albicans associated with echinocandin resistance has raised concerns over the spread of drug-resistant strains. We studied the impact of fks1 mutations on C. albicans virulence and fitness. Compared with wild-type strains for FKS1, echinocandin-resistant C.
R. Ben Ami, G. Garcia Effron, LEWIS, RUSSEL EDWARD, S. Gamarra, K. Leventakos, D. S. Perlin, D. P. Kontoyiannis   +6 more
openaire   +4 more sources

Candidemia among Hospitalized Pediatric Patients Caused by Several Clonal Lineages of Candida parapsilosis

Journal of Fungi, 2022
Candida parapsilosis is the second most common cause of candidemia in some geographical areas and in children in particular. Yet, the proportion among children varies, for example, from 10.4% in Denmark to 24.7% in Tehran, Iran.
Rasmus Krøger Hare, Amir Arastehfar, Søren Rosendahl, Arezoo Charsizadeh, Farnaz Daneshnia, Hamid Eshaghi, Hossein Mirhendi, Teun Boekhout, Ferry Hagen, Maiken Cavling Arendrup   +9 more
doaj   +1 more source

Double-Pole Approximation in Time-Dependent Density Functional Theory [PDF]

, 2005
A simple approximate solution to the linear response equations of time-dependent density functional theory (TDDFT) is given. This extends the single-pole approximation (SPA) to two strongly-coupled poles. The analysis provides both an illustration of how
Appel, Burke, Casida, Fiolhais, Furche, Grabo, Gross, Gross, Görling, Görling, Kohn, Marques, Petersilka, Petersilka, Runge, Scherz, Ullrich, Vasiliev, Wasserman   +18 more
core   +1 more source

New strategic insights into managing fungal biofilms [PDF]

, 2015
Fungal infections have dramatically increased in the last decades in parallel with an increase of populations with impaired immunity, resulting from medical conditions such as cancer, transplantation or other chronic diseases.
Borghi, Elisa, Borgo, Francesca, Morace, Giulia, Nile, Christopher, Rajendran, Ranjith, Ramage, Gordon, Sherry, Leighann   +6 more
core   +4 more sources

Reduced Candida glabrata Susceptibility Secondary to an FKS1 Mutation Developed during Candidemia Treatment [PDF]

Antimicrobial Agents and Chemotherapy, 2008
ABSTRACT We describe a case of recurring Candida glabrata infection in a 68-year-old African-American female on caspofungin therapy. The initial isolate was susceptible, but isolates recovered during following relapses were not.
John D, Cleary, Guillermo, Garcia-Effron, Stanley W, Chapman, David S, Perlin   +3 more
openaire   +2 more sources

Breakthrough Bloodstream Infections Caused by Echinocandin-Resistant Candida tropicalis: An Emerging Threat to Immunocompromised Patients with Hematological Malignancies

Journal of Fungi, 2020
Background. Candida tropicalis is a virulent fungal pathogen for which echinocandins are the primary therapy. Emergence of resistance to echinocandins of C. tropicalis carries potentially ominous therapeutic implications. Methods.
Maroun M. Sfeir, Cristina Jiménez-Ortigosa, Maria N. Gamaletsou, Audrey N. Schuetz, Rosemary Soave, Koen Van Besien, Catherine B. Small, David S. Perlin, Thomas J. Walsh   +8 more
doaj   +1 more source

Impact of FKS1 Genotype on Echinocandin In Vitro Susceptibility in Candida auris and In Vivo Response in a Murine Model of Infection

Antimicrobial Agents and Chemotherapy, 2021
Echinocandins are frontline antifungal agents in the management of invasive infections due to multidrug resistant Candida auris. The study aimed to evaluate echinocandin resistance in C.
Dipti Sharma, R. Paul, S. Rudramurthy, N. Kashyap, S. Bhattacharya, R. Soman, S. Shankarnarayan, D. Chavan, Shreya Singh, P. Das, H. Kaur, Anup K. Ghosh, R. Prasad, K. Sanyal, A. Chakrabarti   +14 more
semanticscholar   +1 more source