New cell wall-affecting antifungal antibiotics [PDF]
, 2013 Capítulo 9.Fungi have emerged worldwide as increasingly frequent causes of healthcare-associated infections. Invasive fungal infections can be life-threatening.
Cortés, Juan Carlos G. +2 more
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Portrait of matrix gene expression in Candida glabrata biofilms with stress induced by different drugs [PDF]
, 2018 (1) Background: Candida glabrata is one of the most significant Candida species associated with severe cases of candidiasis. Biofilm formation is an important feature, closely associated with antifungal resistance, involving alterations of gene ...
Henriques, Mariana, Rodrigues, Célia F.
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The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation [PDF]
, 2017 We thank Cowen lab members for helpful discussions. We also thank David Rogers (University of Tennessee) for sharing microarray analysis of the CAS5 homozygous mutant, and Li Ang (University of Macau) for assistance in optimizing the ChIP-Seq experiments.
Andrews, Brenda J +18 more
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Low Prevalence of fks1 Hot Spot 1 Mutations in a Worldwide Collection of Candida Strains [PDF]
Antimicrobial Agents and Chemotherapy, 2010 ABSTRACT We evaluated the prevalence of fks1 hot spot (HS) 1 mutations among 133 Candida strains from six species displaying various caspofungin MIC values (from ≤0.008 to >8 μg/ml). Only 4 (2.9%) strains displayed FKS1 HS1 amino acid substitutions: 1 C. albicans
Mariana, Castanheira +5 more
openaire +2 more sources
Potential Use of MALDI-ToF Mass Spectrometry for Rapid Detection of Antifungal Resistance in the Human Pathogen Candida glabrata. [PDF]
, 2017 The echinocandins are relatively new antifungal drugs that represent, together with the older azoles, the recommended and/or preferred agents to treat candidaemia and other forms of invasive candidiasis in human patients.
De Carolis, E. +6 more
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Journal of FungiThe opportunistic fungus Candida albicans is the leading cause of invasive candidiasis in immune-compromised individuals. Drugs from the echinocandin (ECN) class, including caspofungin, are used as a first line of therapy against invasive candidiasis ...
Anshuman Yadav +3 more
doaj +1 more source
Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance. [PDF]
, 2016 The fungal pathogen Candida glabrata has emerged as a major health threat since it readily acquires resistance to multiple drug classes, including triazoles and/or echinocandins.
Alexander, B.D. +12 more
core +1 more source
The role of Isocitrate Lyase (ICL1) in the metabolic adaptation of Candida albicans biofilms [PDF]
, 2016 Background A major characteristic of Candida biofilm cells that differentiates them from free-floating cells is their high tolerance to antifungal drugs.
Brown A +8 more
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Biocide Response of Candida auris
Mycoses, Volume 69, Issue 3, March 2026.ABSTRACT Candida auris is an emerging multidrug‐resistant yeast demonstrating remarkable persistence in healthcare environments, contributing to nosocomial transmission and outbreak persistence. Increasing disinfectant failure reports have raised concerns regarding infection control policies, as environmental reservoirs play central roles in its spread.
Sidre Erganis +3 more
wiley +1 more source
Resistance in Candida albicans: exploring the cell wall barrier by proteomics [PDF]
, 2015 The incidence of candidiasis has dramatically increased and bloodstream infections due to different species of Candida are becoming a prime cause of morbidity and mortality in different types of immunocompromised patients.
Angiolella, Letizia +2 more
core +1 more source