Results 201 to 210 of about 698,242 (242)

FLASH radiotherapy enables dose escalation resulting in improved survival in an orthotopic muscle-invasive bladder cancer mouse model. [PDF]

Br J Radiol
Ruan JL, Lee C, Sharma O, Lövgren N, Paillas S, Cooper C, Tullis IDC, Giaccia AJ, Kiltie AE, Petersson K.   +9 more
europepmc   +1 more source

Heatwave‐Resilient Cuticular Microbiota Protect the Leaf Beetle Plagiodera versicolora From Fungal Infection

Integrative Zoology, EarlyView.
ABSTRACT The increasing frequency and intensity of heatwaves—extreme thermal events characterized by prolonged supra‐optimal temperatures—exert profound impacts on global ecosystem stability and species interactions. While the disruptive effects of thermal stress on host physiology and gut microbiota are well documented, the role of cuticular ...
Jiyu Wu, Chengjie Tu, Rongshan Fan, Letian Xu   +3 more
wiley   +1 more source

Gold Nanoparticle-Mediated DNA Damage Under FLASH Electron-Beam Irradiation: A Monte Carlo Study. [PDF]

Nanomaterials (Basel)
Kim CD, Chow JCL.
europepmc   +1 more source

Enhanced fish detection sensitivity in aquatic systems using environmental RNA

Methods in Ecology and Evolution, EarlyView.
Abstract Environmental RNA (eRNA) can potentially augment the biological monitoring ability of the established environmental DNA (eDNA) application in conservation. Despite faster degradation, environmental RNA could offer unique advantages: it may help reduce the legacy signal compared to eDNA, provide insights into physiological status through gene ...
Ana Ramón‐Laca, Ramón Gallego, Carmen Duque, José L. J. Ledesma, Ignacio Doadrio, Kim M. Parsons, Krista M. Nichols, Samantha Engster, Abigail Wells, Ana Riesgo   +9 more
wiley   +1 more source

FLASH Radiotherapy and Organelle-Targeted Radiosensitization in Glioblastoma: A Conceptual and Translational Review. [PDF]

Cancers (Basel)
Tang X, Wang X, Xiao K, Zhu B, Lin F, Zhou L.   +5 more
europepmc   +1 more source

The Functional Role and Molecular Characterization of the Therapeutic Target CLDN6 in Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Background The tight junction protein CLDN6 has been identified as a cancer‐associated cell surface marker that is rarely expressed in healthy tissues. In testicular germ cell tumors (GCT), CLDN6 is particularly detectable in seminomas, embryonal carcinomas, and choriocarcinomas.
Jule Zwick, Margaretha A. Skowron, Gereon Poschmann, Patrick Petzsch, Ann Kathrin Bergmann, Kai Stühler, Jochen Hecht, Daniel Nettersheim   +7 more
wiley   +1 more source

Radiotherapy and tertiary lymphoid structures: balancing immune activation and immune damage in cancer immunotherapy. [PDF]

Mol Cancer
Zhang Y, Li H, Lv S, Meng W, Guo J, Lu Y, Peng L, Chen W, Yang W, Peng X.   +9 more
europepmc   +1 more source

Brain metastasis‐associated fibroblasts shape the tumour microenvironment to enhance cancer cell invasion

Brain Pathology, EarlyView.
Brain metastasis‐associated fibroblasts are active stromal components of the metastatic niche characterised by extracellular matrix remodelling and production of pro‐migratory mediators. They promote monocyte and cancer cell migration and enhance cancer cell invasion while having no growth‐promoting effect on cancer cells.
Barbora Výmolová, Lucie Pfeiferová, Tadeáš Karel Smetana, Petr Výmola, Nikola Ternerová, Michal Zubaľ, Michal Kolář, Jana Šáchová, Soňa Gyönyörová, Eva Balážiová, Magdalena Houdová Megová, Jakub Červenka, Helena Kupcová Skalníková, Michal Španko, Karel Smetana Jr., Lukáš Lacina, David Netuka, Robert Tomáš, Petr Bušek, Aleksi Šedo   +19 more
wiley   +1 more source

Proton Bragg peak flash stereotactic radiosurgery for recurrent glioblastoma reirradiation. [PDF]

Phys Imaging Radiat Oncol
Ma Y, Wang Y, Zhang T, Zhao X, Selvaraj B, Cheng C, Pennock M, Jackson J, Guo W, Mou X, Durkee B, Choi JI, Lin H, Simone CB, Kang M, Wu H.   +15 more
europepmc   +1 more source

Repurposed catechol‐O‐methyltransferase inhibitors tolcapone and entacapone preferentially suppress aggregation and seeding of P301 mutant tau in human neuronal models

British Journal of Pharmacology, EarlyView.
Background and purpose Pathogenic aggregation and propagation of seed‐competent TAU assemblies drive tauopathies. MAPT P301 mutations accelerate aggregation and enhance seed competence, yet pharmacological strategies selectively targeting these pathogenic species remain limited.
Ihor Kozlov, Yu‐Sheng Hung, Sudeep Roy, Alladi Charanraj Goud, Roman Kouřil, Yu‐Hui Wong, Viswanath Das   +6 more
wiley   +1 more source