Results 191 to 200 of about 517,787 (283)

Cationic‐Hydrophilic Di‐Block Copolymers: Surface‐Shielded Vectors for Gene Delivery

Journal of Polymer Science, Volume 63, Issue 6, Page 1419-1432, 15 March 2025.
This study develops synthetic polycationic di‐block carriers for nucleic acid (NA) delivery in gene therapy. Consisting of a cationic block and a hydrophilic block, these carriers efficiently form complexes with NAs and shield them with a protective bioinert layer, enhancing stability during circulation in the bloodstream while reducing undesirable ...
Eliška Hrdá, Ladislav Androvič, Marcela Filipová, Michal Pechar, Richard Laga   +4 more
wiley   +1 more source

Use of apertures in single-energy pristine Bragg peak FLASH radiotherapy. [PDF]

J Appl Clin Med Phys
Ma Y, Selvaraj B, Zhao X, Cheng C, Chen CC, Diao L, Wang Y, Wang Z, Pei Y, Liu L, Yan X, Durkee B, Simone CB, Lin H, Mou X, Kang M.   +15 more
europepmc   +1 more source

Synthesis of Carboxyl Terminated Polymyrcene by Anionic Polymerization Using CO2 as a Terminating Agent

Journal of Polymer Science, EarlyView.
The anionic polymerization of myrcene and termination with carbon dioxide to produce carboxyl terminated chains were investigated. The highest degree of functionalization was obtained in the batch reactor by headspace addition of the CO2 to the unstirred reactor at −78°C.
Trishna K. Chengappa, Juan Marin Angel, Kevin A. Cavicchi   +2 more
wiley   +1 more source

Endocrine therapy‐induced cancer‐related fatigue in hormone‐dependent malignancies: Mechanisms, impact, and management strategies

Precision Medical Sciences, EarlyView.
Multipathway schematic of endocrine therapy–induced cancer‐related fatigue. Endocrine interventions trigger four interacting mechanisms—neuroendocrine dysregulation, systemic inflammation, energy‐metabolic failure, and psycho‐behavioral amplification—that culminate in the multidimensional CRF phenotype.
Jiajing Jiang, Jun Lu, Sen Qin, Ruzhou Chen, Qiuchen Zhang, Lvqi He, Yubei Li, Jingyao Yan   +7 more
wiley   +1 more source

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva, Monique Mantovani, Maria E. S. D. Lino, Aline O. Albuquerque, João H. M. da Silva, Ronaldo A. P. Nagem, Adriana L. Rojas, Geraldo R. Sartori, Eduardo Horjales, David Campbell, Otavio H. Thiemann   +10 more
wiley   +1 more source

Leaf penetration by endophytic Metarhizium brunneum enables infection of Phthorimaea absoluta in tomato mines while inducing the crop defense system

Pest Management Science, EarlyView.
Spraying Metarhizium brunneum on tomato plants controls heterogeneous and upcoming Phthorimaea absoluta populations by infecting larvae within mines and priming plant induced systemic defences. Abstract BACKGROUND The endophytic entomopathogenic fungus Metarhizium brunneum Petch EAMa 01/58‐Su shows strong potential for managing Phthorimaea absoluta, a ...
Esther Aguilera Cuenca, María José García del Rosal, Fabián García Espinoza, Enrique Quesada Moraga, Irene Magdalena Rodríguez Gómez, Meelad Yousef Yousef   +5 more
wiley   +1 more source

Easily Accessible and Up‐Scalable Aliphatic Bis‐Formamides with Afterglow Luminescence: Photoluminescence Properties and Applications

Small, EarlyView.
A bis formamide molecule was found to feature afterglow properties, in both crystalline powder state and in polyvinyl alcohol films. This was attributed to the intermolecular packing that allows H‐trapped emitting state and/or clustering‐triggered emission, which was intensified upon insertion of tetramethylbenzidine as a doping agent.
Chengyi Zhu, Sara Ferrara, Anna Zieleniewska, Daniel Van Opdenbosch, Rubén D. Costa, Youssef Atoini, Jean‐Marie Lehn   +6 more
wiley   +1 more source

Initial Evaluation of Feasibility and Cutaneous Toxicity of Electron FLASH Radiotherapy Using a Standard-of-Care Fractionation Scheme in a Porcine Skin Model. [PDF]

Cancers (Basel)
Konradsson E, Liu K, Baig S, Lin SJ, Lopez AH, Velasquez B, Mayor S, Samuel K, Viscarra T, Garrow K, Moore EJ, Norton W, Swain J, Li Z, Koong AC, Lin SH, Schüler E, Mitra D.   +17 more
europepmc   +1 more source

Unlocking n‐alk‐1‐ynes conformers: Quantum “trigger finger” versus “stiff joint” conformations

Smart Molecules, EarlyView.
Quantum chemical analysis reveals the unique function of n‐alk‐1‐yne terminus as a Quantum “Trigger Finger,” exhibiting two near‐isoenergetic conformers (Cs ${\mathrm{C}}_{s}$and C1 ${\mathrm{C}}_{1}$) locked by a symmetric high barrier. This contrasts with the lower asymmetric barrier of the conventional asymmetric “Stiff Joint” alkyl chain.
Ioan Bâldea
wiley   +1 more source

A Test of the Coase Conjecture Using Prices of Electronic Books

Southern Economic Journal, EarlyView.
ABSTRACT The Coase Conjecture predicts that a durable‐goods monopolist without commitment will rapidly cut price toward marginal cost. We test this prediction in the electronic‐book market using release‐day prices. To proxy for marginal cost, we use competitive prices of public‐domain electronic books on the same platforms.
Tim Groseclose, Alex Tabarrok
wiley   +1 more source