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New Genera of Flavonols and Flavonol Derivatives As Therapeutic Molecules
Journal of the Korean Society for Applied Biological Chemistry, 2011Natural products from plants and microorganisms traditionally have provided the pharmaceutical industry with one of the most important sources of “lead” compounds in the search for new drugs and medicines. The diversity of polyphenol structure is enormous.
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Journal of the Science of Food and Agriculture, 1956
AbstractThe flavonols quercetin‐3‐glucoside (isoquercitrin), kaempferol‐3‐glucoside (astragalin), quercetin‐3‐rhamnoglucoside (rutin), kaempferol‐3‐rhamnoglucoside, quercetin‐3‐rhamno‐diglucoside, and kaempferol‐3‐rhamnodiglucoside, previously isolated and characterized in Japanese green teas, have also been detected in unprocessed tea‐leaf and black ...
E. A. H. Roberts +2 more
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AbstractThe flavonols quercetin‐3‐glucoside (isoquercitrin), kaempferol‐3‐glucoside (astragalin), quercetin‐3‐rhamnoglucoside (rutin), kaempferol‐3‐rhamnoglucoside, quercetin‐3‐rhamno‐diglucoside, and kaempferol‐3‐rhamnodiglucoside, previously isolated and characterized in Japanese green teas, have also been detected in unprocessed tea‐leaf and black ...
E. A. H. Roberts +2 more
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Antinociceptive effect of flavonol and a few structurally related dimethoxy flavonols in mice
Inflammopharmacology, 2019Previous reports suggest flavonoids as potent analgesic compounds. Based on these observations, the present study investigated the antinociceptive action of flavonol, 3', 4'-dimethoxy flavonol, 6, 3'-dimethoxy flavonol, 7, 2'-dimethoxy flavonol, and 7, 3'-dimethoxy flavonol and the possible mechanisms involved in these effects.
Vijaykumar Sayeli +5 more
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Flavonols from Bauhinia malabarica
Journal of Natural Medicines, 2008Bauhinia malabarica Roxb. has been used in Thai traditional medicine for wound healing, as a diuretic, to fight dysentery and as an emmenagogue. Seven flavonols, including 6,8-di-C-methylkaempferol 3-methyl ether, kaempferol, afzelin, quercetin, isoquercitrin, quercitrin, and hyperoside were isolated from the methanol extract of leaves.
Rawiwun, Kaewamatawong +3 more
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The Journal of Organic Chemistry, 2020
A novel synthetic method for flavonol from 2'-hydroxyl acetophenone and benzaldehyde promoted by pyrrolidine under an aerobic condition in water is established. This protocol was supported by efficient synthesis of 44 common examples and three natural products.
Wei Xiong +7 more
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A novel synthetic method for flavonol from 2'-hydroxyl acetophenone and benzaldehyde promoted by pyrrolidine under an aerobic condition in water is established. This protocol was supported by efficient synthesis of 44 common examples and three natural products.
Wei Xiong +7 more
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INHERITANCE OF FLAVONOL GLYCOSIDES IN SOYBEANS
Canadian Journal of Genetics and Cytology, 1973Genetic analysis detected three genes that are involved in the formation of various flavonol glycosides in the leaves of soybeans (Glycine max (L.) Merrill). Eight flavonol classes were observed with each gene showing dominance for glycoside formation. The gene symbols Fg1and fg1, Fg2and fg2, and Fg3and fg3are proposed.
R I, Buzzell, B R, Buttery
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Journal of Medicinal Chemistry, 2008
3',4'-Dihydroxyflavonol (DiOHF) is a cardioprotective flavonol that can reduce injury after myocardial ischemia and reperfusion and thus is a promising small molecule for the treatment of cardiovascular disease. Like all vasoactive flavonols reported to date, DiOHF is both relaxant and antioxidant, hindering investigation of the relative contribution ...
Cheng Xue, Qin +4 more
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3',4'-Dihydroxyflavonol (DiOHF) is a cardioprotective flavonol that can reduce injury after myocardial ischemia and reperfusion and thus is a promising small molecule for the treatment of cardiovascular disease. Like all vasoactive flavonols reported to date, DiOHF is both relaxant and antioxidant, hindering investigation of the relative contribution ...
Cheng Xue, Qin +4 more
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European Journal of Medicinal Chemistry, 2013
A series of chalcone and flavonol derivatives were synthesized in good yield by an eco-friendly approach. A pharmacological evaluation was performed with the human colorectal carcinoma cell line HCT116 and revealed that the anticancer activity of flavonols was higher when compared with that of the respective chalcone precursors.
Tatiana A, Dias +4 more
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A series of chalcone and flavonol derivatives were synthesized in good yield by an eco-friendly approach. A pharmacological evaluation was performed with the human colorectal carcinoma cell line HCT116 and revealed that the anticancer activity of flavonols was higher when compared with that of the respective chalcone precursors.
Tatiana A, Dias +4 more
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Flavonols of Pulicaria arabica
Phytochemistry, 1982Abstract Three quercetagetin methyl ethers, quercetin 3-glucoside, quercetin 3-glucuronide and a sulphated flavonoid were identified in leaves and flowers of Pulicaria arabica .
Sabry I. El-Negoumy +2 more
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