Results 21 to 30 of about 19,247 (245)

Picornavirus infection enhances aspartate by the SLC38A8 transporter to promote viral replication.

PLoS Pathogens, 2023
Foot-and-mouth disease, a class of animal diseases, is caused by foot-and-mouth disease virus (FMDV). The metabolic changes during FMDV infection remain unclear. Here, PK-15 cells, serum, and tonsils infected with FMDV were analyzed by metabolomics.
Huisheng Liu, Zixiang Zhu, Qiao Xue, Fan Yang, Weijun Cao, Zhaoning Xue, Xiangtao Liu, Haixue Zheng   +7 more
doaj   +1 more source

Into the Deep (Sequence) of the Foot-and-Mouth Disease Virus Gene Pool: Bottlenecks and Adaptation during Infection in Naïve and Vaccinated Cattle

Pathogens, 2020
Foot-and-mouth disease virus (FMDV) infects hosts as a population of closely related viruses referred to as a quasispecies. The behavior of this quasispecies has not been described in detail in natural host species. In this study, virus samples collected
Ian Fish, Carolina Stenfeldt, Rachel M. Palinski, Steven J. Pauszek, Jonathan Arzt   +4 more
doaj   +1 more source

Analysis of Foot and Mouth Disease Virus Polyprotein for Multi Peptides Vaccine Design: An In silico Strategy

Journal of Pure and Applied Microbiology, 2022
Foot-and-mouth disease virus (FMDV) is small RNA virus from Picornaviridae family; genus Aphthovirus. FMDV causes maximum levels of infectivity in cattle and harmful socioeconomic effects. The present report attempted to design vaccine candidate from the
Ranya Mohmed Sid Ahmed, Yassir A. Almofti, Khoubieb Ali Abd-elrahman   +2 more
doaj   +1 more source

Foot-and-mouth disease virus localisation on follicular dendritic cells and sustained induction of neutralising antibodies is dependent on binding to complement receptors (CR2/CR1).

PLoS Pathogens, 2022
Previous studies have shown after the resolution of acute infection and viraemia, foot-and-mouth disease virus (FMDV) capsid proteins and/or genome are localised in the light zone of germinal centres of lymphoid tissue in cattle and African buffalo.
Lucy Gordon, Neil Mabbott, Joanna Wells, Liudmila Kulik, Nick Juleff, Bryan Charleston, Eva Perez-Martin   +6 more
doaj   +1 more source

A Single Dose of Dendrimer B₂T Peptide Vaccine Partially Protects Pigs against Foot-and-Mouth Disease Virus Infection

Vaccines, 2020
Foot-and-mouth disease virus (FMDV) causes a highly contagious disease of cloven-hoofed animals whose control relies on efficient vaccination. We have reported that dendrimer peptide B2T, with two copies of FMDV B-cell epitope VP1 (136−154) linked ...
Rodrigo Cañas-Arranz, Mar Forner, Sira Defaus, Patricia de León, María J. Bustos, Elisa Torres, Francisco Sobrino, David Andreu, Esther Blanco   +8 more
doaj   +1 more source

High-Resolution Composition Analysis of an Inactivated Polyvalent Foot-and-Mouth Disease Vaccine

Pathogens, 2020
Appropriate vaccine selection is crucial in the control of foot-and-mouth disease (FMD). Vaccination can prevent clinical disease and reduces viral shedding, but there is a lack of cross-protection between the seven serotypes and their sublineages ...
Leonie F. Forth, Dirk Höper, Martin Beer, Michael Eschbaumer   +3 more
doaj   +1 more source

Transient Expression of Coat Protein of Foot and Mouth Disease Virus (FMDV) in Alfalfa (Medicago sativa) by Agroinfiltration [PDF]

Journal of Cell and Molecular Research, 2016
An Agrobacterium-mediated transient gene expression assay was carried out in alfalfa (Medicago sativa) leaves for expression of a chimeric gene encoding a part of capsid protein of Foot and Mouth Disease virus called VP1.
Maziar Habibi-Pirkoohi, Saeid Malekzadeh-Shafaroudi, Hasan Marashi, Saeid Zibaee, Afsaneh Mohkami, Saba NejatizaXeh   +5 more
doaj   +1 more source

Phospholipase PLA2G16 Accelerates the Host Interferon Signaling Pathway Response to FMDV. [PDF]

Viruses
Sun B, Qin X, Zhang T, Dong S, Ye Y, Wang C, Zhang Y, Hao R, Ru Y, Tian H, Zheng H.   +10 more
europepmc   +2 more sources

The antibody response induced FMDV vaccines in sheep correlates with early transcriptomic responses in blood

npj Vaccines, 2020
Foot and mouth disease (FMD) is a highly contagious viral disease with high economic impact, representing a major threat for cloven-hooved mammals worldwide.
L. Jouneau, D. Lefebvre, F. Costa, A. Romey, S. Blaise-Boisseau, A. Relmy, Y. Jaszczyszyn, Cloelia Dard-Dascot, S. Déjean, Nicolas Versillé, E. Guitton, P. Hudelet, M. Curet, K. De Clercq, L. Bakkali-Kassimi, S. Zientara, B. Klonjkowski, I. Schwartz-Cornil   +17 more
semanticscholar   +1 more source

Dissecting distinct proteolytic activities of FMDV Lpro implicates cleavage and degradation of RLR signaling proteins, not its deISGylase/DUB activity, in type I interferon suppression

PLoS Pathogens, 2020
The type I interferon response is an important innate antiviral pathway. Recognition of viral RNA by RIG-I-like receptors (RLRs) activates a signaling cascade that leads to type I interferon (IFN-α/β) gene transcription.
L. Visser, Chiara Aloise, Kirby N. Swatek, G. Medina, K. Olek, H. Rabouw, R. D. de Groot, M. Langereis, T. de Los Santos, D. Komander, T. Skern, F. V. van Kuppeveld   +11 more
semanticscholar   +1 more source