Crystal structure of the 3C protease from South African Territories type 2 foot-and-mouth disease virus [PDF]
, 2016 The replication of foot-and-mouth disease virus (FMDV) is dependent on the virus-encoded 3C protease (3Cpro). As in other picornaviruses, 3Cpro performs most of the proteolytic processing of the polyprotein expressed from the single open reading frame in
Curry, S, Leen, EN, Maree, FF, Yang, J
core +4 more sources
Induction of protective immune response against both PPRV and FMDV by a novel recombinant PPRV expressing FMDV VP1 [PDF]
Veterinary Research, 2014 AbstractPeste des petits ruminants (PPR) and foot-and-mouth disease (FMD) are both highly contagious diseases of small domestic and wild ruminants caused by the PPR virus (PPRV) and the FMD virus (FMDV). In this study, a recombinant PPRV expressing the FMDV VP1 gene (rPPRV/VP1) was generated and FMDV VP1 expression did not impair replication of the ...
Chunsheng Yin +9 more
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PLoS Pathogens, 2022 Previous studies have shown after the resolution of acute infection and viraemia, foot-and-mouth disease virus (FMDV) capsid proteins and/or genome are localised in the light zone of germinal centres of lymphoid tissue in cattle and African buffalo.
Lucy Gordon +6 more
doaj +1 more source
Differentiation of Foot-and-Mouth Disease-Infected pigs from Vaccinated Pigs Using Antibody-Detecting Sandwich ELISA [PDF]
, 2011 The presence of serum antibodies for nonstructural proteins of the foot-and-mouth disease virus (FMDV) can differentiate FMDV-infected animals from vaccinated animals.
Aldo DEKKER +10 more
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A qualitative risk assessment of factors contributing to foot and mouth disease outbreaks in cattle along the western boundary of the Kruger National Park [PDF]
, 2009 Between November 2000 and the end of 2007, five outbreaks of foot and mouth disease (FMD) occurred in cattle in the area adjacent to the Kruger National Park (KNP) in the north-eastern corner of South Africa.
Bengis, R.G. +6 more
core +1 more source
Virus-like particles of recombinant PCV2b carrying FMDV-VP1 epitopes induce both anti-PCV and anti-FMDV antibody responses [PDF]
Applied Microbiology and Biotechnology, 2018 Mixed infection of porcine circovirus type 2 (PCV2) and foot-and-mouth disease virus (FMDV) is devastating to swine populations. To develop an effective vaccine that can protect the pigs from the infection of PCV2 and FMDV, we used the neutralizing B cell epitope region (aa 135-160) of FMDV to replace the regions aa 123-151 and aa 169-194 of the PCV2b ...
Xin, Li +10 more
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Tolerance to mutations in the foot-and-mouth disease virus integrin-binding RGD region is different in cultured cells and in vivo and depends on the capsid sequence context. [PDF]
, 2008 Engineered RNAs carrying substitutions in the integrin receptor-binding Arg-Gly-Asp (RGD) region of foot-and-mouth disease virus (FMDV) were constructed (aa 141-147 of VP1 capsid protein) and their infectivity was assayed in cultured cells and suckling
Baranowski, Eric +4 more
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Effect of heat on foot-and-mouth disease virus (FMDV) in the components of milk from FMDV-infected cows [PDF]
Journal of Hygiene, 1976 SUMMARYFoot-and-mouth disease virus (FMDV) survived in skim milk, cream and the pelleted cellular debris components of milk obtained from FMDV-infected cows after pasteurization at 72°C for 0·25 min. Virus was recovered from whole milk of infected cows after that milk was heated at 72°C. for 5 min.
J H, Blackwell, J L, Hyde
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DDX56 cooperates with FMDV 3A to enhance FMDV replication by inhibiting the phosphorylation of IRF3
Cellular Signalling, 2019 The components of foot-and-mouth disease virus (FMDV) interact with host cellular proteins to promote self-replication and evade the host immune response. Previous studies have shown that FMDV 3A, 2C and 2B proteins interact with host cellular proteins involved in FMDV replication.
Shao-zu Fu +7 more
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FMDV replicons encoding green fluorescent protein are replication competent [PDF]
Journal of Virological Methods, 2014 The study of replication of viruses that require high bio-secure facilities can be accomplished with less stringent containment using non-infectious 'replicon' systems. The FMDV replicon system (pT7rep) reported by Mclnerney et al. (2000) was modified by the replacement of sequences encoding chloramphenicol acetyl-transferase (CAT) with those encoding ...
Tulloch, Fiona +10 more
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