Results 101 to 110 of about 64,048 (160)

Yersinia type III secretion : send in the effectors [PDF]

, 2002
Pathogenic Yersinia spp (Yersinia pestis, Yersinia pseudotuberculosis, and Yersinia enterocolitica) have evolved an exquisite method for delivering powerful effectors into cells of the host immune system where they inhibit signaling cascades and block ...
Cornelis, G. R.
core   +1 more source

Fak silencing impairs osteogenic differentiation of bone mesenchymal stem cells induced by uniaxial mechanical stretch

Journal of Dental Sciences, 2019
Background/purpose: Mechanical stretch plays a key role in promoting proliferation and differentiation of bone marrow mesenchymal stem cells (BMSCs) in distraction osteogenesis (DO).
Pei Hu, Xiaowen Zhu, Chuang Zhao, Jing Hu, En Luo, Bin Ye   +5 more
doaj   +1 more source

Endothelial Focal Adhesion Kinase Depletion Augments Lung Vascular Permeability by Impairing Sphingosine‐1‐Phosphate Receptor‐1 Function

The FASEB Journal, 2009
We have shown that focal adhesion kinase (FAK), a determinant of cell‐matrix adhesion, maintains endothelial barrier function and limits the increase in endothelial permeability induced by inflammatory mediators. We conditionally depleted endothelial FAK (CD‐FAK) using Tie2‐Cre in FAK‐floxed mice to investigate
Tracy Thennes, Nebojsa Knezevic, Mohammad Tauseef, Seppo Yla‐Herttuala, Tang‐Long Shen, Jun‐Lin Guan, Dolly Mehta   +6 more
openaire   +1 more source

Vascular smooth muscle contraction in hypertension [PDF]

, 2018
Hypertension is a major risk factor for many common chronic diseases, such as heart failure, myocardial infarction, stroke, vascular dementia and chronic kidney disease.
Alves-Lopes, Rheure, Anagnostopoulou, Aikaterini, Arner, Anders, De Lucca Camargo, Livia, Montezano, Augusto C., Rios, Francisco J., Touyz, Rhian M.   +6 more
core   +1 more source

HPK1 associates with SKAP-HOM to negatively regulate Rap1-mediated B-lymphocyte adhesion.

PLoS ONE, 2010
BackgroundHematopoietic progenitor kinase 1 (HPK1) is a Ste20-related serine/threonine kinase activated by a range of environmental stimuli including genotoxic stress, growth factors, inflammatory cytokines and antigen receptor triggering.
Sebastian Königsberger, Doris Peckl-Schmid, Nadja Zaborsky, Irene Patzak, Friedemann Kiefer, Gernot Achatz   +5 more
doaj   +1 more source

Targeting the integrin beta 1‐focal adhesion kinase axis with artemisinin: Biophysical disruption of cell adhesion, migration, and invasion in tongue cancer

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Tongue cancer is a significant threat to human health due to its propensity to spread throughout the oral cavity and to other regions of the head and neck.
Laurensia Danis Anggradita, Joo Hyun Kim, Min‐Kyu Kim, Ji Won Son, Mohd Farhan, Jothilin Subitsha Alex Jeberson, Ali Taghizadeh, Hae‐Won Kim, Jae Hong Park, Jaemoon Yang, Hyung Kwon Byeon, Sung Sik Hur, Myung Jin Ban, Yongsung Hwang   +13 more
doaj   +1 more source

Additional file 1 of Phospho-regulated tethering of focal adhesion kinase to vinculin links force transduction to focal adhesion signaling

Supplementary Material ...
Diaz-Palacios, Karen, López Navajas, Pilar, Rodrigo Martín, Bárbara, Matesanz, Ruth, Luque-Ortega, Juan R., Echarri, Asier, Lietha, Daniel   +6 more
openaire   +1 more source

Prostaglandins in Cancer Cell Adhesion, Migration, and Invasion

International Journal of Cell Biology, 2012
Prostaglandins exert a profound influence over the adhesive, migratory, and invasive behavior of cells during the development and progression of cancer.
David G. Menter, Raymond N. DuBois
doaj   +1 more source

Direct role of interrod spacing in mediating cell adhesion on Sr-HA nanorod-patterned coatings

International Journal of Nanomedicine, 2014
Jianhong Zhou,1 Yong Han,1 Shemin Lu2 1State Key Laboratory for Mechanical Behavior of Materials, 2Department of Genetics and Molecular Biology, College of Medicine, Xi'an Jiaotong University, Xi'an, People's Republic of China Abstract: The ...
Zhou J, Han Y, Lu S
doaj  

Mechanical Stretch Control of Adipocyte AKT Signaling and the Role of FAK and ROCK Mechanosensors

Bioengineering
Adipose tissue in vivo is physiologically exposed to compound mechanical loading due to bodyweight bearing, posture, and motion. The capability of adipocytes to sense and respond to mechanical loading milieus to influence metabolic functions may provide ...
Tasneem Bouzid, Eunju Kim, Brandon D. Riehl, Ruiguo Yang, Viswanathan Saraswathi, Jason K. Kim, Jung Yul Lim   +6 more
doaj   +1 more source