Results 61 to 70 of about 6,078 (136)

Activin A: its role and involvement in inflammatory diseases [PDF]

, 2015
Activin proteins are members of the transforming growth factor-β family. Activin A is involved in several biological responses including wound repair, cell death, proliferation and differentiation of many cell types.
Basir, Rusliza, Chuah, Yaw Kuang, Nordin, Norshariza, Talib, Herni, Tie, Tung Hing   +4 more
core  

Lifelong exercise, but not short-term high-intensity interval training, increases GDF11, a marker of successful aging: a preliminary investigation [PDF]

, 2017
Lifelong exercise is associated with regulation of skeletal mass and function, reductions in frailty, and successful aging. Yet, the influence of exercise on myostatin and myostatin-interacting factors is relatively under examined in older males ...
Amthor, Bell, Bowling, Cassidy, Drummond, Egerman, Elliott, Elliott, Gilson, Gonzalez-Cadavid, Grace, Hayes, Hayes, Hayes, Herbert, Herbert, Herbert, Hill, Horrington, Kambadur, Knowles, Lee, Lunsford, Metter, Mosher, Pollock, Pugh, Ramos, Ratkevicius, Roth, Rowe, Saremi, Sculthorpe, Shiraev, Sinha, Thum, Walker, Walker, Whittemore, Yarasheski, Zhou, Zimmers   +41 more
core   +3 more sources

Maternal Serum Activin A, Inhibin A and Follistatin-Related Proteins across Preeclampsia: Insights into Their Role in Pathogenesis and Prediction.

Journal of mother and child, 2023
Within the endocrine-paracrine signalling network at the maternal-foetal interface, the activin-inhibin-follistatin system modulates extravillous trophoblast invasion, suggesting a potential role in preeclampsia pathogenesis. This study aimed to compile the evidence published in the last decade regarding the variation in maternal serum activins ...
Barrero, Jorge A., Villamil-Camargo, Laura M., Imaz, Jose N., Arciniegas-Villa, Karen, Rubio-Romero, Jorge A.   +4 more
openaire   +2 more sources

Analysis of gene expression profiles in HeLa cells in response to overexpression or siRNA-mediated depletion of NASP

Reproductive Biology and Endocrinology, 2009
Background NASP (Nuclear Autoantigenic Sperm Protein) is a linker histone chaperone required for normal cell division. Changes in NASP expression significantly affect cell growth and development; loss of gene function results in embryonic lethality ...
Alekseev Oleg, Richardson Richard T, Alekseev Oleg M, O'Rand Michael G   +3 more
doaj   +1 more source

Multi-Cancer Computational Analysis Reveals Metastasis-Associated Variant of Desmoplastic Reaction Involving INHBA and THBS2 [PDF]

, 2010
Despite extensive research, the details of the metastasis-associated biological mechanisms are largely unknown. Here, we analyze data from multiple cancers using a novel computational method identifying sets of genes whose coordinated overexpression ...
Dimitris Anastassiou, Hoon Kim, John Watkinson, Vinay Varadan   +3 more
core   +1 more source

Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells [PDF]

, 2006
The POU domain transcription factor OCT4 is a key regulator of pluripotency in the early mammalian embryo and is highly expressed in the inner cell mass of the blastocyst. Consistent with its essential role in maintaining pluripotency, Oct4 expression is
Adjaye, J., Babaie, Y., Brink, T., Burdon, T., Greber, B., Groth, D., Herwig, R., Lehrach, H., Wruck, W.   +8 more
core   +2 more sources

The role of Follistatin-like 3 (Fstl3) in cardiac hypertrophy and remodelling

, 2011
Follistatins are extracellular inhibitors of TGF-β family ligands like activin A, myostatin and bone morphogenetic proteins. Follistatin-like 3 (Fstl3) is a potent inhibitor of activin signalling and antagonises the cardioprotective role of activin A in ...
Panse, Kalyani, Panse, Kalyani
core   +1 more source

Agrin isoforms and their role in synaptogenesis [PDF]

, 1992
Agrin is thought to mediate the motor neuron-induced aggregation of synaptic proteins on the surface of muscle fibers at neuromuscular junctions. Recent experiments provide direct evidence in support of this hypothesis, reveal the nature of agrin ...
Escher, Gérard, Honig, Lawrence S., Horton, Sharon E., Kröger, Stephan, McMahan, U. J., Ruegg, Markus A., Werle, Michael J.   +6 more
core   +1 more source

Prognostic Significance of Proteomics‐Discovered Circulating Inflammatory Biomarkers in Patients With Pulmonary Arterial Hypertension

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Pulmonary arterial hypertension (PAH) ultimately leads to right ventricular failure and premature death. The identification of circulating biomarkers with prognostic utility is considered a priority.
Tetsuro Yokokawa, Olivier Boucherat, Sandra Martineau, Sarah‐Eve Lemay, Sandra Breuils‐Bonnet, Vinod Krishna, Shanker Kalyana‐Sundaram, Jey Jeyaseelan, François Potus, Sébastien Bonnet, Steeve Provencher   +10 more
doaj   +1 more source

Global gene expression in endometrium of high and low fertility heifers during the mid-luteal phase of the estrous cycle [PDF]

, 2014
peer-reviewedBackground In both beef and dairy cattle, the majority of early embryo loss occurs within the first 14 days following insemination.
Diskin, Michael G., Kenny, David A., Killeen, Aideen P., Morris, Dermot G., Mullen, Michael P., Waters, Sinead M.   +5 more
core   +1 more source