Results 41 to 50 of about 3,161,043 (305)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

From Cookbooks to Networks: A Framework for Comparing Multiethnic Ingredient Systems in Transylvania

Foods
Cookbooks serve as structured records of both ingredient repertoires and the underlying processing logics that define a culture’s culinary identity. By modeling five Transylvanian ethnic traditions—Hungarian, Romanian, Transylvanian Saxon, Jewish, and ...
Zsolt Magyari-Sáska, Attila Magyari-Sáska, Lóránt Bálint-Bálint   +2 more
doaj   +1 more source

THE DEVELOPMENT ADVANCED GRANULATION TECHNOLOGY OF COMPOUND FEEDS

Harčova Nauka ì Tehnologìâ, 2019
The advantages of using granular mixed fodders in comparison whith the loose сompound feeds have been analyzed in the article. A detailed analysis of the production of granulated feed in the world and in Ukraine for the last ten years has been presented.
B. Yegorov, N. Batievskaya
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Beyond perception of convenience: Exploring student use of food delivery services

Review of Management, Accounting, and Business Studies
This research investigated the underlying issues influencing students' use of food delivery services beyond the established convenience factor. The study utilized a qualitative approach, employing thematic analysis to gain a deeper understanding of how ...
Jersey Kirsten Barcelona, Cynic Cynic, Marie Jo Tess Ragos, Vhon Ivan Libunao, Mary Ann Misa   +4 more
doaj   +1 more source

Investigating outbreaks caused by foodborne diseases and determining common bacterial agents that cause them in Kurdistan province [PDF]

Cellular, Molecular and Biomedical Reports
Foodborne diseases are a global problem that is spreading day by day. These diseases are one of the most common causes of death in children and the elderly.
Mohammad Mehdi Soltan Dallal, Zahra Rajabi, Mohammad Reza Mohammadi, Arezoo Bagheri Sadegi   +3 more
doaj   +1 more source

Low-Cost Investment with High Quality Performance. Bleaching Earths for Phosphorus Reduction in the Low-Temperature Bleaching Process of Rapeseed Oil

Foods, 2020
Rapeseed oils are a valuable component of the diet. Mostly, there are refined oils deprived of valuable nutrients in the market, hence in recent times cold-pressed and unrefined oils have been available and popular among consumers. However, the low yield
Barbara Łaska-Zieja, Damian Marcinkowski, Wojciech Golimowski, Gniewko Niedbała, Ewelina Wojciechowska   +4 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Development of a Predictive Model for the Biological Activity of Food and Microbial Metabolites Toward Estrogen Receptor Alpha (ERα) Using Machine Learning

Big Data and Cognitive Computing
The interaction of estrogen receptor alpha (ERα) with various metabolites—both endogenous and exogenous, such as those present in food products, as well as gut microbiota-derived metabolites—plays a critical role in modulating the hormonal balance in the
Maksim Kuznetsov, Olga Chernyavskaya, Mikhail Kutuzov, Daria Vilkova, Olga Novichenko, Alla Stolyarova, Dmitry Mashin, Igor Nikitin   +7 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source