Results 261 to 270 of about 106,447 (316)

Multifunctional tumor vaccines carrying thalidomide regulate T cell exhaustion and ferroptosis for immunotherapy strategies

VIEW, EarlyView.
MTV can greatly achieved antigen presenting cell (APCs), and THA will be released from the polyplex core and enhanced antigen presenting, thereby prompting APC maturation and antigen presenting. The membrane antigens on MTV are degraded into small peptides by proteasomes and presented by MHC complexes.
Anmin Huang, Ting Li, Ying Zhou, Sihang Li, Jian Zhang, Yingchao Li, Shijia Wu, Yifan Kong, Zhijie Yu, Jinglin Xia   +9 more
wiley   +1 more source

STAT6 inhibition stabilizes induced regulatory T cells and enhances their therapeutic potential in inflammatory bowel disease. [PDF]

Immunol Res
Arroyo-Olarte RD, Pérez-Noriega FA, Correa-Pérez MF, Mejía-Muñoz A, Terrazas LI, Leon-Cabrera S.   +5 more
europepmc   +1 more source

Resveratrol attenuates areca nut extract‐induced chronic colitis by suppressing pyroptosis of intestinal epithelial cells via modulating cGAS/STING signaling

VIEW, EarlyView.
Areca nut extract (ANE), commonly consumed in some cultures, can damage gut cells by triggering inflammation and cell death through a pathway called cGAS‐STING. This leads to the release of harmful inflammatory substances and weakens the gut barrier. Our study shows that resveratrol, a natural compound found in foods like grapes, can block this harmful
Jing Zhang, Muhammad Tufail, Yu‐Qi Huang, Can‐Hua Jiang, Ning Li   +4 more
wiley   +1 more source

Immunomodulation of UVB-induced regulatory T cells prevents the establishment of squamous cell carcinoma. [PDF]

J Immunother Cancer
Anwaar S, Ashraf A, Jahfali S, Yunis J, Gonzalez Cruz JL, Wells JW.   +5 more
europepmc   +1 more source

Pathogenesis of Vitiligo: Integrating Immune and Non‐Immune Cell Crosstalk

The Journal of Dermatology, EarlyView.
ABSTRACT Vitiligo is an acquired autoimmune disease characterized by depigmented macules resulting from melanocyte loss. It is a complex multifactorial disorder in which genetic predisposition is combined with environmental factors; however, its detailed etiology remains unclear.
Shintaro Inoue
wiley   +1 more source

Daphnetin alleviates unexplained recurrent spontaneous abortion by regulating the NR4A1/BACH2 axis in mice. [PDF]

Biol Res
Zhang Z, Tan J, Wu X, Li X, Liu P, Cao L, Long S.   +6 more
europepmc   +1 more source

Obesity Impairs Skin Barrier Function and Facilitates Allergic Sensitization in Mice

Allergy, EarlyView.
Diet‐induced obesity increases transepidermal water loss and compromises barrier function through downregulation of tight junctions and desmosomes. During obesity, MC903 elicits a mixed Th1/2/17 immune response in the skin leading to aggravated ear swelling.
Alicia Martinek, Andrea Deinzer, Roman G. Gerlach, Jana Petzold, Lea Semmler, Christof Vorsatz, Padraic G. Fallon, Christian Schwartz   +7 more
wiley   +1 more source

Temporal and context-dependent requirements for the transcription factor Foxp3 expression in regulatory T cells. [PDF]

Nat Immunol
Hu W, Dolsten GA, Wang EY, Beroshvili G, Wang ZM, Ghelani AP, Uhl LFK, Bou-Puerto R, Huang X, Michaels AJ, Hoyos BE, Jin W, Pritykin Y, Rudensky AY.   +13 more
europepmc   +1 more source

FOXP3+ T Cells-An Emerging Evidence in Periodontitis Therapeutics. [PDF]

Clin Exp Dent Res
Ünsal RBK, Hasuike A, Badawy T, Asa'ad F, Špiljak B, Yuwanati M, Roganović J, Liu Y, Brigi C, Zambrano DM, Chaurasia A.   +10 more
europepmc   +1 more source

<i>Fusobacterium nucleatum</i> drives CD40-mediated dendritic cell activation and Th17/Treg imbalance to exacerbate intestinal inflammation in Crohn's disease. [PDF]

Front Immunol
Wang M, Sun J, Yu J, Wang J, Xu C, Ma J, Zhang H.   +6 more
europepmc   +1 more source