Results 261 to 270 of about 160,147 (340)

Deciphering Immunosenescence From Child to Frailty: Transcriptional Changes, Inflammation Dynamics, and Adaptive Immune Alterations

Aging Cell, EarlyView.
Integrated analysis of bulk‐cell and single‐cell RNA‐seq data from childhood to frailty revealed nonlinear transcriptomic changes in peripheral blood mononuclear cells, marked by dramatic early‐life shifts in inflammation, myeloid cells, and lymphocyte features, followed by stability in healthy elderly individuals.
Wenpu Lai, Qiuyue Feng, Wen Lei, Chanchan Xiao, Juan Wang, Yi Zhu, Lipeng Mao, Yue Zhu, Jiacheng He, Yangqiu Li, Hao Wang, Zhenhua Li, Guobing Chen, Oscar Junhong Luo   +13 more
wiley   +1 more source

Foxp3 Represses Retroviral Transcription by Targeting Both NF-κB and CREB Pathways

, 2006
Christian Grant, Unsong Oh, Kazunori Fugo, Norihiro Takenouchi, Caitlin Griffith, Karen Yao, Timothy E. Newhook, Lee Ratner, Steven Jacobson   +8 more
openalex   +2 more sources

Conversion of T Effector Cells Into T Regulatory Cells in Type 1 Diabetes/Latent Autoimmune Diabetes of Adults by Inhibiting eIF5A and Notch Pathways. [PDF]

Immunotargets Ther
Rafiqi SI, Aldasouqi A, Paparodis RD, Dewan S, Farooqi A, Faisal S, Nemat Y, Salim N, Qureshi S, Mahmood A, Tovar Y, Jun JY, Kalinoski AL, Mirmira RG, Jaume JC, Imam S.   +15 more
europepmc   +1 more source

Age‐Related Oxidative Stress and Mitochondrial Dysfunction in Lymph Node Stromal Cells Limit the Peripheral T Cell Homeostatic Maintenance and Function

Aging Cell, EarlyView.
Aging of the lymph node stromal cells limits their ability to support the survival and maintenance of peripheral naive T cells. The lymph node stromal cells are critical for providing the survival and trophic signals to peripheral naïve T cells, and after the early‐life thymic involution, these secondary lymphoid organ stromal microniches are decisive ...
Sandip Ashok Sonar, Ruchika Bhat, Heather L. Thompson, Christopher P. Coplen, Jennifer L. Uhrlaub, Mladen Jergovic, Janko Ž. Nikolich   +6 more
wiley   +1 more source

Extracellular vesicles from human semen induce unique tolerogenic phenotypes in vaginal dendritic cells and regulatory T lymphocytes. [PDF]

Front Immunol
Paktinat S, Gravett MG, Tobey C, Kirby A, Horner W, Shaffer R, Fialkow M, Nguyen NP, Gornalusse GG, Kalatehjari M, Hughes SM, Hladik F, Vojtech L.   +12 more
europepmc   +1 more source

Multi‐Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single‐Blinded Randomized Placebo‐Controlled Therapeutic Plasma Exchange

Aging Cell, EarlyView.
Therapeutic plasma exchange safely reduces biological age by up to 2.6 years. Multi‐omics analysis reveals coordinated cellular and molecular responses associated with aging rejuvenation. ABSTRACT We conducted a randomized, placebo‐controlled trial to assess the safety and biological age (BA) effects of various therapeutic plasma exchange (TPE ...
Matias Fuentealba, Dobri Kiprov, Kevin Schneider, Wei‐Chieh Mu, Prasanna Ashok Kumaar, Herbert Kasler, Jordan B. Burton, Mark Watson, Heather Halaweh, Christina D. King, Zehra Stara Yüksel, Chelo Roska‐Pamaong, Birgit Schilling, Eric Verdin, David Furman   +14 more
wiley   +1 more source

Identification of M1 macrophage infiltration-related genes for immunotherapy in Her2-positive breast cancer based on bioinformatics analysis and machine learning. [PDF]

Sci Rep
Wang S, Wang X, Xia J, Mu Q.
europepmc   +1 more source

Aging Compromises Terminal Differentiation Program of Cytotoxic Effector Lineage and Promotes Exhaustion in CD8+ T Cells Responding to Coronavirus Infection

Aging Cell, EarlyView.
In a MHV infection model with age‐associated increased mortality, we demonstrate that aging impairs, instead of promoting, the terminal differentiation program of virus‐specific CD8+ T cells through downregulating key transcriptional regulators of terminal differentiation.
Ziang Zhu, Guohua Lou, Ying Luo, Kiddist Yihunie, Jonathan Hoar, Juan A. Daniel, Bret M. Evers, Chen Yao, Tuoqi Wu   +8 more
wiley   +1 more source

Invisible appliance promotes bone reconstruction via modulating the periodontal immune microenvironment. [PDF]

Eur J Med Res
Wong H, Huang Y, Yang P.
europepmc   +1 more source

Expression of Foxp3 in non-small cell lung cancer patients is significantly higher in tumor tissues than in normal tissues, especially in tumors smaller than 30 mm

, 2006
Yasunori Ishibashi, Shigebumi Tanaka, Kohei Tajima, Takeshi Yoshida, Hiroyuki Kuwano   +4 more
openalex   +2 more sources