Results 261 to 270 of about 199,492 (387)

Lipid metabolism reprograming by SREBP1‐PCSK9 targeting sensitizes pancreatic cancer to immunochemotherapy

Cancer Communications, EarlyView.
Abstract Background Pancreatic cancer's aberrant lipid metabolism fuels cell growth, invasion, and metastasis, yet its impact on immune surveillance and immunotherapy is unclear. This study investigated how sterol regulatory element‐binding transcription factor 1 (SREBP1)‐driven lipid metabolism affects the tumor microenvironment (TME) in pancreatic ...
Mengyi Lao, Xiaozhen Zhang, Zejun Li, Kang Sun, Hanshen Yang, Sicheng Wang, Lihong He, Yan Chen, Hanjia Zhang, Jiatao Shi, Daqian Xu, Tingbo Liang, Xueli Bai   +12 more
wiley   +1 more source

Trichinella spiralis adult excretory-secretory antigen promotes peripheral regulatory T cell differentiation and attenuates experimental colitis via TGF-β-like mechanisms. [PDF]

Parasit Vectors
Sun XM, Luo ZN, Wang W, Hao CY, Li ZA, El-Ashram S, Zhu XP.   +6 more
europepmc   +1 more source

Glucocorticoid amplifies IL‐2‐dependent expansion of functional FoxP3⁺CD4⁺CD25⁺ T regulatory cells in vivo and enhances their capacity to suppress EAE [PDF]

, 2006
Xin Chen, Joost J. Oppenheim, Robin Winkler-Pickett, John R. Ortaldo, O. M. Zack Howard   +4 more
openalex   +1 more source

Ubiquitination in cancer: mechanisms and therapeutic opportunities

Cancer Communications, EarlyView.
Abstract Ubiquitination, a key post‐translational modification, plays an essential role in tumor biology by regulating fundamental cellular processes, such as metabolism and cell death. Additionally, it interacts with other post‐translational modifications, which are closely linked to tumorigenesis, tumor progression, the tumor microenvironment, and ...
Susi Zhu, Xu Zhang, Waner Liu, Zhe Zhou, Siyu Xiong, Jie Li, Xiang Chen, Cong Peng   +7 more
wiley   +1 more source

Inducible protein degradation reveals inflammation-dependent function of the T_reg cell lineage-defining transcription factor Foxp3. [PDF]

Sci Immunol
Jäger C, Dimitrova P, Sun Q, Tennebroek J, Marchiori E, Jaritz M, Rauschmeier R, Estivill G, Obenauf A, Busslinger M, van der Veeken J.   +10 more
europepmc   +1 more source

Faculty Opinions recommendation of Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter.

, 2005
Torben Lund
openalex   +2 more sources

Expression and functional characterization of FOXP3+CD4+ regulatory T cells in ulcerative colitis [PDF]

, 2006
Qi Yu, Masayuki Saruta, Armine Avanesyan, Phillip Fleshner, Alison H. Banham, Konstantinos A. Papadakis   +5 more
openalex   +1 more source

Mechanisms of foxp3+ T regulatory cell-mediated suppression.

Immunity, 2009
E. Shevach
semanticscholar   +1 more source

Targeting Ubiquitin‐Specific Protease 7 with Novel 5‐Amino‐Pyrazole Inhibitors: Design, Synthesis, and Biological Evaluation

ChemMedChem, EarlyView.
Ubiquitin‐specific protease 7 (USP‐7) is a novel target for anticancer therapy. To further extend the structure–activity relationships of the previously USP‐7 inhibitor STIRUR‐41, a library of 5‐aminopyrazoles is reported. 1d shows a potency comparable to lead compound STIRUR‐41 and promising in silico and in vitro pharmacokinetic properties ...
Matteo Lusardi, Elva Morretta, Andrea Spallarossa, Maria Chiara Monti, Camillo Rosano, Erika Iervasi, Marco Ponassi, Matteo Mori, Fiorella Meneghetti, Chiara Brullo   +9 more
wiley   +1 more source

Full-Length Transcriptome Sequencing Reveals Treg-Specific Isoform Expression upon Activation. [PDF]

Int J Mol Sci
Sato Y, Osada E, Manome Y.
europepmc   +1 more source