Results 91 to 100 of about 960 (168)

Integrating multi‐omics features enables non‐invasive early diagnosis and treatment response prediction of diffuse large B‐cell lymphoma

Clinical and Translational Medicine
Background Multi‐omics features of cell‐free DNA (cfDNA) can effectively improve the performance of non‐invasive early diagnosis and prognosis of cancer. However, multimodal characterization of cfDNA remains technically challenging.
Weilong Zhang, Bangquan Ye, Yang Song, Ping Yang, Wenzhe Si, Hairong Jing, Fan Yang, Dan Yuan, Zhihong Wu, Jiahao Lyu, Kang Peng, Xu Zhang, Lingli Wang, Yan Li, Yan Liu, Chaoling Wu, Xiaoyu Hao, Yuqi Zhang, Wenxin Qi, Jing Wang, Fei Dong, Zijian Zhao, Hongmei Jing, Yanzhao Li   +23 more
doaj   +1 more source

Plasma DNA Profile Associated with DNASE1L3 Gene Mutations: Clinical Observations, Relationships to Nuclease Substrate Preference, and In Vivo Correction

, 2020
International audiencePlasma DNA fragmentomics is an emerging area in cell-free DNA diagnostics and research. In murine models, it has been shown that the extracellular DNase, DNASE1L3, plays a role in the fragmentation of plasma DNA. In humans, DNASE1L3
Chan, K, C Allen, Han, Diana, S C, Serpas, Lee, Rashidfarrokhi, Ali, Lau, Pik, Ki, Ni, Meng, Hiraki, Linda, T, Chan, Rebecca, W y, Wong, Priscilla, C H, Volpi, Stefano, Lo, Y, M Dennis, Tam, Lydia, H P, Peng, Wenlei, Sisirak, Vanja, Buti, Elisa, Lee, Wing-Shan, Tam, Lai-Shan, Chiu, Rossa W K, Magnasco, Alberto, Wang, Yueyang, Reizis, Boris, Jiang, Peiyong, Cheng, Alice, S H, Tse, Patty, P P, Almutairi, Nora   +24 more
core   +1 more source

Leveraging cfDNA fragmentomic features for the early detection of colorectal cancer

Frontiers in Immunology
Background Early detection of colorectal cancer (CRC) is crucial for improving patient outcomes. Cell-free DNA (cfDNA) analysis has emerged as a promising non-invasive approach for cancer detection. This study aims to develop a machine learning algorithm leveraging cfDNA fragmentomic features to accurately ...
Shan, Lina, Xu, Dengyong, Chen, Jie, Liu, Wenjia, Lin, Ji, Bao, Juhang, Huang, Jianfei, Zhang, Hanqing, Zhao, Hanchen, Xue, Wei, Lin, Ziao, Bai, Bingjun   +11 more
openaire   +1 more source

Detection and characterization of pancreatic and biliary tract cancers using cell-free DNA fragmentomics

Journal of Experimental & Clinical Cancer Research
Background Plasma cell-free DNA (cfDNA) fragmentomics has demonstrated significant differentiation power between cancer patients and healthy individuals, but little is known in pancreatic and biliary tract cancers.
Xiaohan Shi, Shiwei Guo, Qiaonan Duan, Wei Zhang, Suizhi Gao, Wei Jing, Guojuan Jiang, Xiangyu Kong, Penghao Li, Yikai Li, Chuanqi Teng, Xiaoya Xu, Sheng Chen, Baoning Nian, Zhikuan Li, Chaoliang Zhong, Xiaolu Yang, Guangyu Zhu, Yiqi Du, Dadong Zhang, Gang Jin   +20 more
doaj   +1 more source

Fragmentation signatures in cancer patients resemble those of patients with vascular or autoimmune diseases

Multiple case-controlled studies have shown that analyzing fragmentation patterns in plasma cell-free DNA (cfDNA) can distinguish individuals with cancer from healthy controls.
Kinzler, KW, Liu, T, O’Reilly, E, Mulder, F, Li, A, Vogelstein, B, Dobbyn, L, Ho-Pham, LT, Bettegowda, C, Popoli, M, Mecoli, CA, Panda, S, Xu, H, Bai, Y, Konig, MF, Papadopoulos, N, Wang, Y, Ptak, J, Douville, C, Silliman, N, van Es, N, Tie, J, Curtis, SD, Shah, AA, Thoburn, C, Tran, TS, Tran, BNH, Nguyen, TV, Gibbs, P, Rosen, A, Vogelstein, JT, Petri, M   +31 more
core   +1 more source

Protein-oligopeptide fragmentomics

, 2008
8
openaire   +2 more sources

Integration of Cell-Free DNA End Motifs and Fragment Lengths Can Identify Active Genes in Liquid Biopsies

Multiple studies have shown that cell-free DNA (cfDNA) from cancer patients differ in both fragment length and fragment end motif (FEM) from healthy individuals, yet there is a lack of understanding of how the two factors combined are associated with ...
Anders Lade Nielsen, Christoffer Trier Maansson, Peter Meldgaard, Louise Skov Thomsen, Boe Sandahl Sorensen   +4 more
core   +1 more source

Advances of nanopore direct sequencing technology and bioinformatics analysis for cell-free DNA detection and its clinical applications in cancer liquid biopsy

Frontiers in Molecular Biosciences
Cell-free DNA (cfDNA) containing cancer information has become a key biomarker for cancer liquid biopsy. Current next-generation sequencing (NGS) technology for cfDNA detection often fail to capture multiomics information, such as fragmentomics ...
Jiaxin Tan, Jiaxin Tan, Zetong Wu, Yunya Zhu, Biyuan Miao, Biyuan Miao, Daofeng Xu, Jia Gu, Maohong Hu, Pingping Xu, Shaogui Wan   +10 more
doaj   +1 more source

Keap1-Inhibitory Peptides from Ganoderma lucidum Spores: Virtual Enzymolysis, Fragmentomics and Antioxidant Mechanism

Molecules
Ganoderma lucidum spores protein (GLSP) holds significant potential for providing antioxidant peptides. We employed in silico enzymatic hydrolysis to generate small peptide fragments by specific proteins.
Beibei Chen, Liang He, Qi Huang, Yanbin Wang   +3 more
doaj   +1 more source

The Method of Minimal Residual Disease Detection With Circulating Tumor DNA and Its Clinical Applications in Colorectal Cancer

Cancer Reports
Background Colorectal cancer (CRC) remains a significant health concern in the world. The existing standard of care guidelines for CRC surveillance fall short of effectively and timely detecting recurrence or metastasis.
Ming Liu, Tianhao Mu, Jia Gu, Mingyan Xu, Shifu Chen   +4 more
doaj   +1 more source