Results 101 to 110 of about 960 (168)

Stratified Medicine Paediatrics: Cell free DNA and serial tumour sequencing identifies subtype specific cancer evolution and epigenetic states [PDF]

We profiled a large heterogenous cohort of matched diagnostic-relapse tumour tissue and paired plasma-derived cell free DNA (cfDNA) from patients with relapsed and progressive solid tumours of childhood.
Tall, Jennifer, Elliott, Martin, Cresswell, George D, Turnbull, Jennifer, Chesler, Louis, Tweddle, Deborah A, Jacques, Thomas S, Howell, Lisa, Proszek, Paula Z, Shipley, Janet M, Clifford, Steven C, Al-Lazikani, Bissan, Ronghe, Milind, Jamal, Sabri, Hutchinson, J Ciaran, Sauer, Carolin M, Waqar Ahmed, Saira, Jesudason, Angela, Cortes-Ciriano, Isidro, Wilson, Shaun, Burke, GA Amos, Chalker, Jane, Yuan, Lina, Vedi, Aditi, Marshall, Lynley V, Grundy, Richard G, Hubank, Michael, Ross, Emma, Stoneham, Sara, Anderson, John, Rees, Helen, Adams, Madeleine, Lynn, Claire, Jones, Chris, Angelini, Paola, Johnston, Robert, Vormoor, Josef, George, Sally L, Rogers, Tony, Makin, Guy, Shaikh, Ridwan, Lee, Victoria, Sottoriva, Andrea, Stankunaite, Reda, Graham, Trevor A, Kearns, Pamela, Oostveen, Minou, Willis, Courtney, Gray, Juliet C, Hughes, Debbie, Brew, Ama, Campbell-Hewson, Quentin, Gatz, Susanne A, Hargrave, Darren   +53 more
core   +1 more source

Revealing Cell‐Free Mitochondrial DNA Breakage Patterns as Novel Biomarkers for Sepsis

Accurate early diagnosis and prognosis of sepsis remain major clinical challenges. This study explores specific plasma cell‐free mitochondrial DNA (cfmtDNA) breakage patterns as potential biomarkers for sepsis.
Zhenchun Luo, Xuxin Tan, Liangming Liu, Jianfeng Huang, Wei Shen, Chenyang Duan, Ruiyan Ma, Zhezhe Cao, He Huang, Xue Zeng, Haitang Liao, Bing Chen, Shuai Hao, Rui Song   +13 more
core   +1 more source

Sinteza nove piridinijeve soli s triazolilidenskim fragmentom

, 2020
This thesis describes the synthesis of a novel pyridinium salt bearing triazolylidene fragment bounded to pyridine nitrogen atom, which has not yet been described in the literature. The synthesized salt represents a potential bidentate dicarbene NHC ligand, useful for the formation of transition metal NHC complexes.
openaire   +1 more source

Nanopore-based consensus sequencing enables accurate multimodal tumor cell-free DNA profiling

Shallow genome-wide cell-free DNA sequencing holds great promise for noninvasive cancer monitoring by providing reliable copy number alteration (CNA) and fragmentomic profiles.
van Laarhoven, Hanneke, Pagès-Gallego, Marc, Kloosterman, Wigard, van den Ende, Tom, Kloosterman, Wigard P., Vanderlinden, Willem, van der Pol, Ymke, Kolbeck, Pauline, Brink, Geertruid J., Mouliere, Florent, de Ridder, Jeroen, Hami, Nizar, Chen, Li-Ting, Mouliere, Florent; id_orcid, Rebergen, Dàmi, Derks, Sarah, Moldovan, Norbert, Lipfert, Jan, Zweemer, Ronald, Marcozzi, Alessio, Besselink, Nicolle, Jager, Myrthe   +21 more
core   +1 more source

fRagmentomics: an R package for integrating cell-free DNA fragment features with mutational status to support liquid biopsy interpretation. [PDF]

Bioinformatics
Maudet K, Samaniego J, Pradat Y, Bernard E.   +3 more
europepmc   +1 more source

Chasing the code : Advancing Precision Diagnostics through Next Generation Sequencing

Next generation sequencing (NGS) has revolutionized precision diagnostics by enabling high-throughput analysis of nucleic acids. This thesis combines technical validations with innovative applications of NGS across five studies.
Adolfsson, Emma
core  

From concept to clinic: emerging paradigms and novel insights into liquid biopsy. [PDF]

Cancer Biol Med
Guo W, Liu Y, Dong H, Li X, Guo X, Guo H, Zhou K, Xing J.   +7 more
europepmc   +1 more source

Unravelling the Significance of Extracellular Vesicle-Associated DNA in Cancer Biology and Its Potential Clinical Applications

Extracellular vesicles (EVs) play a key role in cell-to-cell communication and have drawn significant attention due to their potential clinical applications. However, much remains to be understood about the biology of EV-associated DNA (EV-DNA).
Licha, Kristina, Reinhardt, Dirk, Lötvall, Jan,, Pour, Ommolbanin Asad, Chetty, Venkatesh Kumar, Tamasova, Barbora, Ghanam, Jamal, Thakur, Basant Kumar, Hoyer, Peter   +8 more
core   +1 more source

Emerging Role of ctDNA Fragmentomics and Epigenetic Signatures in the Early Detection, Minimal Residual Disease Assessment, and Precision Monitoring of Renal Cell Carcinoma. [PDF]

J Cell Mol Med
Kamli H, Khan NU.
europepmc   +1 more source

Circulating cell-free mtDNA fragmentomics for early detection of gastric cancer and precancerous lesions. [PDF]

Cell Rep Med
Dang M, Wang S, Zhang H, Xu H, Lu L, Liu Y, Jiao H, Yang W, Peng F, Gao X, Lin F, Dong K, Pan K, Li W, Lu R, Nie Y, Liu Y, Xing J.   +17 more
europepmc   +1 more source