Results 81 to 90 of about 960 (168)

Abstract 3350: Cell-free DNA fragmentation patterns analyzed in over 15000 cancer patients reveal changes associated with tumor somatic mutations and result in improved sensitivity and specificity of somatic variant detection

, 2017
Background: Cell-free DNA (cfDNA) isolated from plasma consists of DNA fragments surviving clearance of dying cells and bloodstream trafficking. In cancer, these fragments carry the footprint of tumor somatic variation as well as its microenvironment ...
AmirAli Talasaz, Diana Abdueva, Helmy Eltoukhy, Darya Chudova   +3 more
core   +1 more source

Clinical Application of Peripheral Blood Biomarkers for Solid Tumors

MedComm, Volume 7, Issue 3, March 2026.
Peripheral blood biomarkers provide a minimally invasive, dynamic, and potentially more accurate means to obtain a comprehensive tumor profile. Technologies for detecting them are advancing, and with the help of artificial intelligence, they are being used more and more often for cancer diagnosis, prognostic assessment, and therapeutic monitoring ...
Xinru Tu, Mengyan Tu, Junfen Xu
wiley   +1 more source

Toward Timely Diagnosis of Pancreatic Cancer: Revolutionizing Early Detection Through Genomics, Artificial Intelligence, and Noninvasive Biomarkers

Journal of Gastroenterology and Hepatology, Volume 41, Issue 3, Page 895-913, March 2026.
ABSTRACT Background Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive cancers, typically diagnosed at an advanced stage due to its subtle and often absent early symptoms. Despite representing only 3% of new cancer cases, it is projected to become the second leading cause of cancer‐related deaths by 2030.
Muhammad Masroor Hussain, Sana Qammar, Ju‐Mei Wang, Ao‐Qiang Zhai, Fu‐yu Li, Hai‐jie Hu   +5 more
wiley   +1 more source

Genomic and fragmentomic landscapes of cell-free DNA for early cancer detection

Nature Reviews Cancer
Genomic analyses of cell-free DNA (cfDNA) in plasma are enabling noninvasive blood-based biomarker approaches to cancer detection and disease monitoring. Current approaches for identification of circulating tumour DNA typically use targeted tumour-specific mutations or methylation analyses.
Daniel C. Bruhm, Nicholas A. Vulpescu, Zachariah H. Foda, Jillian Phallen, Robert B. Scharpf, Victor E. Velculescu   +5 more
openaire   +3 more sources

Early detection of malignant and premalignant peripheral nerve tumors using cell-free DNA fragmentomics

PURPOSE: Early detection of neurofibromatosis type 1 (NF1)-associated peripheral nerve sheath tumors (PNST) informs clinical decision-making, enabling early definitive treatment and potentially averting deadly outcomes.
Burgic, Sanita, Chrisinger, John S A, et al.,, Hirbe, Angela C, Armstrong, Amy E, Sundby, R Taylor, Srihari, Divya, Weekley, Kara, Chamberlain, Stacey, Jones, Paul A   +9 more
core   +2 more sources

Genome-wide cfDNA fragmentation patterns in cerebrospinal fluid reflect medulloblastoma groups

npj Precision Oncology
Identifying molecular groups in medulloblastoma currently requires invasive biopsies for accurate diagnosis. We analyzed cerebrospinal fluid cell-free DNA (cfDNA) fragmentation patterns in 122 samples as a minimally-invasive alternative.
Alexander L Markowitz, Chetan Munugula, Eirini Christodoulou, Jianling Ji, Liya Xu, Jennifer A Cotter, Venkata Yellapantula   +6 more
doaj   +1 more source

A method of comprehensive sequencing analysis of the small RNA fragmentome (RiboMarker)

RNA
Circulating cell-free nucleic acids (cfDNA and cfRNA) found in blood and other biofluids are promising biomarkers for cancer. However, current methods exploiting tumor-derived cfDNA (ctDNA) are not sensitive enough in detecting minimal residual disease and early stages of cancer when it is more treatable.
Rachel C. Clark, Aidan C. Manning, Jonathan M. Howard, Sergio Barberán-Soler, Sergei A. Kazakov   +4 more
openaire   +2 more sources

Fragmentomics of plasma mitochondrial and nuclear DNA inform prognosis in COVID-19 patients with critical symptoms

Background The mortality rate of COVID-19 patients with critical symptoms is reported to be 40.5%. Early identification of patients with poor progression in the critical cohort is essential to timely clinical intervention and reduction of mortality ...
Fang Zheng, Xin Jin, Yeqin Wang, Wenwen Zhou, Rong Xie, Ye Tao, Jinjin Xu, Rijing Ou, Yilin Chen, Yu Lin, Yong Bai, Yuxue Luo, Haiqiang Zhang, Yan Zhang, Lingguo Li, Yan Jin, Ruokai Qu, Fanjun Cheng   +17 more
core   +1 more source

Cell-Free DNA Fragments as Biomarkers in Radiooncology and Gynecology [PDF]

Liquid biopsy of cell-free DNA (cfDNA) is a non-invasive diagnostic method that provides valuable biological insights into various diseases by analyzing DNA fragments released into the bloodstream.
Ivankovic, Ivna
core   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source