Results 91 to 100 of about 9,249 (168)

Conformational effects of N-glycan core fucosylation of immunoglobulin G Fc region on its interaction with Fcγ receptor IIIa

Scientific Reports, 2017
Antibody-dependent cellular cytotoxicity (ADCC) is promoted through interaction between the Fc region of immunoglobulin G1 (IgG1) and Fcγ receptor IIIa (FcγRIIIa), depending on N-glycosylation of these glycoproteins.
Yoshitake Sakae, Tadashi Satoh, Hirokazu Yagi, Saeko Yanaka, Takumi Yamaguchi, Yuya Isoda, Shigeru Iida, Yuko Okamoto, Koichi Kato   +8 more
doaj   +1 more source

Age-related dysregulation of intestinal epithelium fucosylation is linked to an increased risk of colon cancer

JCI Insight
Colon cancer affects people of all ages. However, its frequency, as well as the related morbidity and mortality, are high among older adults. The complex physiological changes in the aging gut substantially limit the development of cancer therapies. Here,
Zhihan Wang, Pan Gao, Kai Guo, Grace Schirrick, Jappreet Singh Gill, Jett Weis, Abby Lund Da Costa, Mansib Rahman, Het Mehta, Julia Fleecs, Shilpi Jain, Trishna Debnath, Junguk Hur, Nadeem Khan, Robert Sticca, Holly M. Brown-Borg, Donald A. Jurivich, Ramkumar Mathur   +17 more
doaj   +1 more source

Exploring the diverse biological significance and roles of fucosylated oligosaccharides

Frontiers in Molecular Biosciences
Long since, carbohydrates were thought to be used just as an energy source and structural material. However, in recent years, with the emergence of the field of glycobiology and advances in glycomics, much has been learned about the biological role of ...
Burcu Pekdemir, Sercan Karav
doaj   +1 more source

GDP‐fucose transporter SLC35C1: a potential regulatory role in cytosolic GDP‐fucose and fucosylated glycan synthesis

FEBS Open Bio
Glycosylation occurs mainly in the Golgi apparatus, whereas the synthesis of nucleotide sugars occurs in the cytoplasm or nucleus. GDP‐fucose in mammalian cells could be produced via de novo and salvage pathways in the cytoplasm; the first one is ...
Edyta Skurska, Mariusz Olczak
doaj   +1 more source

Fucosyl Monosialotetrahexosylganglioside [PDF]

, 2020
openaire   +1 more source

A Chemoenzymatic Method To Systematically Quantify Core Fucosylation Stoichiometry of Glycoproteins and Reveal Its Roles in EMT and Embryonic Development. [PDF]

Anal Chem
Xu S, Xu X, Yin K, Wu R.
europepmc   +1 more source

Fut8-Mediated Core Fucosylation of Toll-Like Receptor 4 Exacerbates Periodontitis Via Hyperactivation of NF-κB Signalling. [PDF]

Int Dent J
Lin J, Luo Y, Chen L, Zeng C, Wang L, Luo X, Zeng L, Xu H, Chen Z.   +8 more
europepmc   +1 more source

Immunoglobulin G N-glycosylation remodeling in viral infections: immunomodulatory roles and potential biomarker implications. [PDF]

Front Immunol
Yan R, Wang C, Zhao X, Wang Y, Liu M, Shi X, Chen H, Li D.   +7 more
europepmc   +1 more source

N-glycomics profiling reveals alteration of fucosylation in early acute ischemic stroke from mouse brain tissue to human serum. [PDF]

Clin Proteomics
Wu Y, Hu L, Huang J, Zhong Y, Li K, Qiu Z, Su L, Zhang Y, Liu W.   +8 more
europepmc   +1 more source

Microsecond Dynamics of Fc-CD16a Recognition: Impact of Mutations, Core Fucosylation, and Fc Asymmetry. [PDF]

Antibodies (Basel)
Estaran S, Hehlen B, Chavanieu A.
europepmc   +1 more source