Results 1 to 10 of about 14,397 (162)

Fucosyltransferase 8 (FUT8) and core fucose expression in oxidative stress response. [PDF]

PLoS ONE, 2023
GlycoMaple is a new tool to predict glycan structures based on the expression levels of 950 genes encoding glycan biosynthesis-related enzymes and proteins using RNA-seq data.
Yuki M Kyunai, Mika Sakamoto, Mayuko Koreishi, Yoshio Tsujino, Ayano Satoh   +4 more
doaj   +6 more sources

Effects of microRNAs on fucosyltransferase 8 (FUT8) expression in hepatocarcinoma cells. [PDF]

PLoS ONE, 2013
Fucosyltransferase 8 (FUT8) catalyzes the transfer of α1,6-linked fucose to the first N-acetylglucosamine in N-linked glycans (core fucosylation). Increased core fucosylation has been reported during hepatocarcinogenesis, in both cell-associated and ...
Cinzia Bernardi, Ugo Soffientini, Francesco Piacente, Michela G Tonetti   +3 more
doaj   +6 more sources

Overexpression of fucosyltransferase 8 reverses the inhibitory effect of high-dose dexamethasone on osteogenic response of MC3T3-E1 preosteoblasts [PDF]

PeerJ, 2021
Background Core fucosylation catalyzed by FUT8 is essential for TGF-β binding to TGF-β receptors. Methods Indirect TGF-β1 binding assay was used to evaluate the ability of TGF-β1 to bind to TGFBRs, Alizarin red and alkaline phosphatase staining were used
Zhiming Wu, Tianye Lin, Pan Kang, Zhikun Zhuang, Haibin Wang, Wei He, Qiushi Wei, Ziqi Li   +7 more
doaj   +5 more sources

Partial silencing of fucosyltransferase 8 gene expression inhibits proliferation of Ishikawa cells, a cell line of endometrial cancer [PDF]

Biochemistry and Biophysics Reports, 2020
Endometrial cancer is the most common gynecologic malignancy and is associated with increased morbidity each year, including young people. However, its mechanisms of proliferation and progression are not fully elucidated.
Hana Shimoyama, Toshiaki K. Shibata, Masahiko Ito, Tomoaki Oda, Toshiya Itoh, Mari Mukai, Madoka Matsuya-Ogawa, Masashi Adachi, Hirotake Murakami, Takeshi Nakayama, Kazuhiro Sugihara, Hiroaki Itoh, Tetsuro Suzuki, Naohiro Kanayama   +13 more
doaj   +4 more sources

Analysis of L1 Cell Adhesion Molecule and Fucosyltransferase 8 Expression in Cells After Stretch and Human EACSCC Tissue [PDF]

Journal of International Advanced Otology
Background: External auditory canal (EAC) squamous cell carcinoma (SCC) is classified as a rare cancer and has a poor prognosis at advanced stages. Mechanical stress has been implicated in external auditory canal squamous cell carcinoma (EACSCC), but the
Naotaro Akiyama, Tomomi Yamamoto-Fukuda, Hiromi Kojima   +2 more
doaj   +4 more sources

Activated p53 with Histone Deacetylase Inhibitor Enhances L-Fucose-Mediated Drug Delivery through Induction of Fucosyltransferase 8 Expression in Hepatocellular Carcinoma Cells. [PDF]

PLoS ONE, 2016
The prognosis of advanced hepatocellular carcinoma (HCC) is dismal, underscoring the need for novel effective treatments. The α1,6-fucosyltransferase (fucosyltransferase 8, FUT8) has been reported to accelerate malignant potential in HCC. Our study aimed
Yutaka Okagawa, Kohichi Takada, Yohei Arihara, Shohei Kikuchi, Takahiro Osuga, Hajime Nakamura, Yusuke Kamihara, Naotaka Hayasaka, Makoto Usami, Kazuyuki Murase, Koji Miyanishi, Masayoshi Kobune, Junji Kato   +12 more
doaj   +5 more sources

Fucosyltransferase 8 is Overexpressed and Influences Clinical Outcomes in Lung Adenocarcinoma Patients. [PDF]

Pathol Oncol Res, 2022
Background: Lung adenocarcinoma (LUAD), the most prevalent type of lung cancer, is often metastatic and has a poor prognosis. Recent studies have demonstrated an important role for fucosyltransferase 8 (FUT8) in carcinogenesis and cancer progression.Methods: A meta-analysis with 15 eligible datasets from Gene Expression Omnibus (GEO) was performed to ...
Liang Y, Wang T, Gao R, Jia X, Ji T, Shi P, Xue J, Yang A, Chen M, Han P.   +9 more
europepmc   +4 more sources

Fucosyltransferase 8 regulation and breast cancer suppression by transcription factor activator protein 2γ. [PDF]

Cancer Sci, 2021
AbstractAlterations of glycosyltransferase expression are often associated with tumor occurrence and progression. Among the many glycosyltransferases, increased expression of fucosyltransferase 8 (FUT8) has been frequently observed to be involved in progression and metastasis of various types of cancer.
Ma M, Guo D, Tan Z, Du J, Guan F, Li X.
europepmc   +4 more sources

Structural basis of substrate recognition and catalysis by fucosyltransferase 8. [PDF]

J Biol Chem, 2020
AbstractFucosylation of the inner-most N-acetyl-glucosamine (GlcNAc) of N-glycans by fucosyltransferase 8 (FUT8) is an important step in the maturation of complex and hybrid N-glycans. This simple modification can have a dramatic impact on the activity and half-life of glycoproteins.
Järvå MA, Dramicanin M, Lingford JP, Mao R, John A, Jarman KE, Grinter R, Goddard-Borger ED.   +7 more
europepmc   +4 more sources

A genetic variation in fucosyltransferase 8 accelerates HIV-1 disease progression indicating a role for N-glycan fucosylation. [PDF]

AIDS, 2023
Objectives: Core fucosylation by fucosyltransferase 8 (FUT8) is an important posttranslational modification that impacts components of the immune system. Genetic variations in FUT8 can alter its function and could, therefore, play a role in the antiviral immune response and pathogenesis of HIV-1.
van Pul L, Maurer I, Boeser-Nunnink BDM, Harskamp AM, van Dort KA, Kootstra NA.   +5 more
europepmc   +4 more sources