Results 11 to 20 of about 14,436 (200)

Fucosyltransferase 8 as a functional regulator of nonsmall cell lung cancer. [PDF]

Proc Natl Acad Sci U S A, 2013
The up-regulation of fucosyltransferase 8 (FUT8), the only enzyme catalyzing α1,6-fucosylation in mammals, has been observed in several malignant cancers including liver, ovarian, thyroid, and colorectal cancers. However, the pathological role and the regulatory mechanism of FUT8 in cancers remain largely unknown.
Chen CY, Jan YH, Juan YH, Yang CJ, Huang MS, Yu CJ, Yang PC, Hsiao M, Hsu TL, Wong CH.   +9 more
europepmc   +4 more sources

Exploiting human fucosyltransferase 8 allostery with a covalent inhibitor for core fucosylation suppression [PDF]

Nature Communications
Core fucosylation, catalyzed by fucosyltransferase 8 (FUT8), plays critical roles in cancer progression, immune evasion, and drug resistance, making it a compelling therapeutic target.
Jiheng Jiang, Dongyang He, Mengyu Ke, Jinhua Qin, Guang Yang, Biao Yu, Jing Wang, Pengfei Fang   +7 more
doaj   +2 more sources

Fucosyltransferase 8‐Derived Circular RNA Drives M2 Polarization of Macrophages Through ENO1‐TNF Signaling Axis to Promote Lung Cancer Progression [PDF]

Thoracic Cancer
Background Lung cancer, representing a predominant form of pulmonary malignancy, demonstrates significant disease burden and poor clinical outcomes. Circular RNAs (circRNAs) have emerged as critical regulators in various cancers, including lung cancer ...
Yang Ren, Yidan Shen, Qingguo Wu, Peng Zhang, Lei Wang, Feng Li, Yinzhong Shen   +6 more
doaj   +2 more sources

Fucosyltransferase 3 and 8 promote the metastatic capacity of cancer stem-like cells via CD15s and E-cadherin in esophageal cancer [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Esophageal cancer stem cells (ECSCs) have been identified as the subset of cells within esophageal squamous cell carcinoma that possess tumorigenic, invasive, and metastatic properties.
Aliakbar Rostami Abookheili, Jahanbakhsh Asadi, Ayyoob Khosravi, Ali Gorji   +3 more
doaj   +3 more sources

O-Fucosyltransferase SPINDLY attenuates auxin-induced fruit growth by inhibiting ARF6/8-coactivator mediator complex interaction in Arabidopsis

Nature Communications
The phytohormone auxin plays a pivotal role in promoting fruit initiation and growth upon fertilization in flowering plants. Upregulation of auxin signaling by genetic mutations or exogenous auxin treatment can induce seedless fruit formation from ...
Yan Wang, Seamus Kelley, Rodolfo Zentella, Jianhong Hu, Hua Wei, Lei Wang, Jeffrey Shabanowitz, Donald F. Hunt, Tai-ping Sun   +8 more
doaj   +3 more sources

Core Fucosylation Represses SMURF1‐Dependent Degradation of CD47 to Promote Tumor Immune Evasion

Advanced Science
Glycosylation, the covalent attachment of glycans to proteins, lipids, and RNAs, is fundamental in regulating diverse biological processes. Glycosylation patterns are aberrantly altered in the tumor microenvironment and closely associated with tumor ...
Yuting Cao, Siyuan Chai, Mingyang Li, Xiaoming Chen, Jiating Hu, Bingyi Lin, Liming Wu, Wen Yi, Qiang Zhu   +8 more
doaj   +2 more sources

FUT3–B3GNT3 interaction promotes pancreatic cancer progression and chemoresistance via NF-κB signaling mediated autophagy [PDF]

European Journal of Medical Research
Pancreatic ductal adenocarcinoma (PDAC) is prone to drug resistance and a role for fucosyltransferase 3 (FUT3) is increasingly recognized. The current study investigated the mechanisms by which FUT3 contributes to PDAC.
Lei Jin, Wenjie Han, Junwei Zou, Xiaolei Tang, Peng Chen, Hao Xie, Bing Zhou, Daohai Qian, Yue Yu   +8 more
doaj   +2 more sources

Glycoengineering of AAV-delivered monoclonal antibodies yields increased ADCC activity

Molecular Therapy: Methods & Clinical Development, 2021
The absence of fucose on asparagine-297 of the human immunoglobulin G (IgG) heavy chain has been shown to enhance antibody-dependent cellular cytotoxicity (ADCC) activity by 10- to 100-fold compared to fucosylated antibody. Our lab is studying the use of
James M. Termini, José M. Martinez-Navio, Guangping Gao, Sebastian P. Fuchs, Ronald C. Desrosiers   +4 more
doaj   +1 more source

FUT8 (fucosyltransferase 8 (alpha (1,6) fucosyltransferase)) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on FUT8 (fucosyltransferase 8 (alpha (1,6) fucosyltransferase)), with data on DNA, on the protein encoded, and where the gene is implicated.
Ihara, H, Gao, CX, Ikeda, Y, Taniguchi, N   +3 more
openaire   +2 more sources

Association of fucosyltransferase 8 (FUT8) polymorphism Thr267Lys with pulmonary emphysema [PDF]

Journal of Human Genetics, 2011
The fucosyltransferase 8 gene (FUT8) encodes an enzyme that transfers fucose to the innermost N-acetylglucosamine unit of N-glycan chains. Recent study showed that fut8-deficient mice develop pathological and physiological phenotypes resembling pulmonary emphysema (PE). The role of FUT8 in human PE is not known.
Miki, Yamada, Takeo, Ishii, Shinobu, Ikeda, Makiko, Naka-Mieno, Noriko, Tanaka, Tomio, Arai, Toshio, Kumasaka, Akihiko, Gemma, Kozui, Kida, Masaaki, Muramatsu, Motoji, Sawabe   +10 more
openaire   +2 more sources