Results 21 to 30 of about 14,436 (200)

IgG1-Dominant Antibody Response Induced by Recombinant Trimeric SARS-CoV-2 Spike Protein with PIKA Adjuvant

Vaccines, 2023
Recombinant trimeric SARS-CoV-2 Spike protein with PIKA (polyI:C) adjuvant induces potent and durable neutralizing antibodies that protect against multiple SARS-CoV-2 variants. The immunoglobulin subclasses of viral-specific antibodies remain unknown, as
Jingxia Wang, Xinjia Mai, Yu He, Chenxi Zhu, Dapeng Zhou   +4 more
doaj   +1 more source

Protein glycosylation as a diagnostic and prognostic marker of chronic inflammatory gastrointestinal and liver diseases [PDF]

, 2020
Glycans are sequences of carbohydrates that are added to proteins or lipids to modulate their structure and function. Glycans modify proteins required for regulation of immune cells, and alterations have been associated with inflammatory conditions.
Callewaert, Nico, Colombel, Jean-Frederic, Dias, Ana M, Pinho, Salome S, Van Vlierberghe, Hans, Verhelst, Xavier, Vermeire, Severine   +6 more
core   +1 more source

Advances in the study of core fucosylation in mammals

浙江大学学报. 农业与生命科学版, 2021
Glycosylation is a major posttranslational modification, which involves in the regulation of important physiological functions. Among them, core fucosylation is an α1, 6-linked fucose to N-glycans, which catalyzes by only one glycosyltransferase.
TIAN Yinping, YI Wen
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Fucosylation Promotes Cytolytic Function and Accumulation of NK Cells in B Cell Lymphoma

Frontiers in Immunology, 2022
Natural killer (NK) cells have been demonstrated as a promising cellular therapy as they exert potent anti-tumor immune responses. However, applications of NK cells to tumor immunotherapy, especially in the treatment of advanced hematopoietic and solid ...
Xing Tong, Xing Tong, Xing Tong, Xing Tong, Yuhua Ru, Yuhua Ru, Yuhua Ru, Jianhong Fu, Jianhong Fu, Jianhong Fu, Ying Wang, Ying Wang, Ying Wang, Jinjin Zhu, Jinjin Zhu, Jinjin Zhu, Yiyang Ding, Yiyang Ding, Yiyang Ding, Fulian Lv, Fulian Lv, Fulian Lv, Menglu Yang, Menglu Yang, Menglu Yang, Xiya Wei, Xiya Wei, Xiya Wei, Chenchen Liu, Chenchen Liu, Chenchen Liu, Xin Liu, Xin Liu, Xin Liu, Lei Lei, Lei Lei, Lei Lei, Xiaojin Wu, Xiaojin Wu, Xiaojin Wu, Lingchuan Guo, Yang Xu, Yang Xu, Yang Xu, Jie Li, Peng Wu, Huanle Gong, Huanle Gong, Huanle Gong, Jia Chen, Jia Chen, Jia Chen, Depei Wu, Depei Wu, Depei Wu   +54 more
doaj   +1 more source

Fucosyltransferase 1 and 2 play pivotal roles in breast cancer cells. [PDF]

, 2019
FUT1 and FUT2 encode alpha 1, 2-fucosyltransferases which catalyze the addition of alpha 1, 2-linked fucose to glycans. Glycan products of FUT1 and FUT2, such as Globo H and Lewis Y, are highly expressed on malignant tissues, including breast cancer ...
Chang, Nai-Chuan, Chen, I-Ju, Ho, Ching-Liang, Lai, Tai-Yu, Lee, Andy Chi-Lung, Liao, Guo-Shiou, Lin, Ruey-Jen, Wu, Jen-Chine, Yeo, Hui-Ling, Yu, Alice L   +9 more
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FDW028, a novel FUT8 inhibitor, impels lysosomal proteolysis of B7-H3 via chaperone-mediated autophagy pathway and exhibits potent efficacy against metastatic colorectal cancer

Cell Death and Disease, 2023
Metastatic colorectal cancer (mCRC) is a major cause of cancer-related mortality due to the absence of effective therapeutics. Thus, it is urgent to discover new drugs for mCRC.
Mengmeng Wang, Zhoudong Zhang, Mengxi Chen, Yixin Lv, Sheng Tian, Fanyi Meng, Yawen Zhang, Xuqin Guo, Yinshuang Chen, Man Yang, Jiawei Li, Tian Qiu, Fang Xu, Zhi Li, Qi Zhang, Jie Yang, Jing Sun, Hongjian Zhang, Haiyang Zhang, Huanqiu Li, Weipeng Wang   +20 more
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The possibility of positive selection for both F18(+) Escherichia coli and stress resistant pigs opens new perspectives for pig breeding [PDF]

, 2007
International ...
Coddens, Annelies, Cox, Eric, Duchateau, Luc, Goddeeris, Bruno, GOYVAERTS, E, MIRY, C, MULINGE, M, Verdonck, Frank   +7 more
core   +3 more sources

Alpha-(1,6)-fucosyltransferase (FUT8) affects the survival strategy of osteosarcoma by remodeling TNF/NF-κB2 signaling

Cell Death and Disease, 2021
Glycosylation is an important modification of membrane proteins that results in functional changes in many cellular activities, from cell-cell recognition to regulatory signaling.
Shanyi Lin, Lenian Zhou, Yang Dong, Qingcheng Yang, Quanjun Yang, Hanqiang Jin, Ting Yuan, Shumin Zhou   +7 more
doaj   +1 more source

Std fimbriae-fucose interaction increases Salmonella-induced intestinal inflammation and prolongs colonization [PDF]

, 2019
Author summary The intestinal epithelium is a crucial biological interface, interacting with both commensal and pathogenic microorganisms. It’s lined with heavily glycosylated proteins and glycolipids which can act as both attachment sites and energy ...
Baines, J., Boyle, E., Casadesús, J., Gal-Mor, O., Galeev, A., García Pastor, L., Grassl, G., Hensel, M., Riedel, R., Seeger, K., Sharma, S., Sterzenbach, T., Suwandi, A.   +12 more
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Downregulating Notch counteracts KrasG12D-induced ERK activation and oxidative phosphorylation in myeloproliferative neoplasm. [PDF]

, 2019
The Notch signaling pathway contributes to the pathogenesis of a wide spectrum of human cancers, including hematopoietic malignancies. Its functions are highly dependent on the specific cellular context. Gain-of-function NOTCH1 mutations are prevalent in
Chang, Yuan-I, Hofmann, Inga, Kong, Guangyao, Letson, Christopher, Liu, Yangang, Loh, Mignon, Padron, Eric, Pear, Warren S, Qian, Shuiming, Rajagopalan, Adhithi, Ranheim, Erik A, Stieglitz, Elliot, Wen, Zhi, Yang, David, You, Xiaona, Zhang, Jing, Zhang, Jingfang, Zhang, Xinmin, Zhong, Xuehua, Zhou, Lan, Zhou, Yun   +20 more
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