Electrostatic interactions mediate the nucleation and growth of a bacterial functional amyloid [PDF]
Frontiers in Molecular Biosciences, 2023 Bacterial biofilm formation can have severe impacts on human and environmental health. Enteric bacteria produce functional amyloid fibers called curli that aid in biofilm formation and host colonization. CsgA is the major proteinaceous component of curli
Sujeet S. Bhoite +3 more
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Why are Functional Amyloids Non-Toxic in Humans? [PDF]
Biomolecules, 2017 Amyloids were first identified in association with amyloidoses, human diseases in which proteins and peptides misfold into amyloid fibrils. Subsequent studies have identified an array of functional amyloid fibrils that perform physiological roles in ...
Matthew P. Jackson, Eric W. Hewitt
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Tuning Functional Amyloid Formation Through Disulfide Engineering [PDF]
Frontiers in Microbiology, 2020 Many organisms produce “functional” amyloid fibers, which are stable protein polymers that serve many roles in cellular biology. Certain Enterobacteriaceae assemble functional amyloid fibers called curli that are the main protein component of the biofilm
Anthony Balistreri +3 more
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Functional amyloid protein FXR1 is recruited into neuronal stress granules [PDF]
PrionThe FXR1 protein regulates the stability and translation of a number of RNA molecules and plays an important role in the regulation of cellular processes under normal conditions and stress.
Anna A. Valina +7 more
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Amyloid Imaging in Aging and Dementia: Testing the Amyloid Hypothesis In Vivo [PDF]
Behavioural Neurology, 2009 Amyloid imaging represents a major advance in neuroscience, enabling the detection and quantification of pathologic protein aggregations in the brain. In this review we survey current amyloid imaging techniques, focusing on positron emission tomography ...
G. D. Rabinovici, W. J. Jagust
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Remediation of Metal Oxide Nanotoxicity with a Functional Amyloid [PDF]
Advanced ScienceUnderstanding the environmental health and safety of nanomaterials (NanoEHS) is essential for the sustained development of nanotechnology. Although extensive research over the past two decades has elucidated the phenomena, mechanisms, and implications of
Yue Wang +10 more
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Direct Identification of Functional Amyloid Proteins by Label-Free Quantitative Mass Spectrometry [PDF]
Biomolecules, 2017 Functional amyloids are important structural and functional components of many biofilms, yet our knowledge of these fascinating polymers is limited to a few examples for which the native amyloids have been isolated in pure form.
Heidi N. Danielsen +6 more
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Functional network phenotypes of mild behavioural impairment: cognitive effects moderated by amyloid [PDF]
Alzheimer’s Research & TherapyBackground Mild behavioural impairment (MBI) is a neurobehavioural syndrome that represents an at-risk state for incident cognitive decline. No study to date has systematically investigated whole-brain within- and between- network functional connectivity
Kok Pin Ng +10 more
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The Amyloid Region of Hfq Riboregulator Promotes DsrA:rpoS RNAs Annealing
Biology, 2021 Hfq is a bacterial RNA chaperone which promotes the pairing of small noncoding RNAs to target mRNAs, allowing post-transcriptional regulation. This RNA annealing activity has been attributed for years to the N-terminal region of the protein that forms a ...
Florian Turbant +3 more
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Apomorphine Targets the Pleiotropic Bacterial Regulator Hfq
Antibiotics, 2021 Hfq is a bacterial regulator with key roles in gene expression. The protein notably regulates translation efficiency and RNA decay in Gram-negative bacteria, thanks to its binding to small regulatory noncoding RNAs. This property is of primary importance
Florian Turbant +6 more
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