Results 11 to 20 of about 304,354 (194)
Functional Amyloid Formation within Mammalian Tissue.
PLoS Biology, 2005 Amyloid is a generally insoluble, fibrous cross-beta sheet protein aggregate. The process of amyloidogenesis is associated with a variety of neurodegenerative diseases including Alzheimer, Parkinson, and Huntington disease.
Douglas M Fowler +5 more
doaj +6 more sources
Functional Mammalian Amyloids and Amyloid-Like Proteins [PDF]
Life, 2020 Amyloids are highly ordered fibrous cross-β protein aggregates that are notorious primarily because of association with a variety of incurable human and animal diseases (termed amyloidoses), including Alzheimer’s disease (AD), Parkinson’s disease (PD ...
Maria S. Rubel +6 more
doaj +3 more sources
The emerging concept of functional amyloid [PDF]
Journal of Internal Medicine, 2009 Abstract.Although amyloid has usually been considered a pathological structure, growing evidence indicates that amyloid may also be a productive part of cell biology contributing to normal physiology. In fact, amyloid formation seems to be an intrinsic propensity of polypeptides in general and the amyloid β‐fold an evolutionary highly conserved ...
openaire +4 more sources
Functional Domains and Evolutionary History of the PMEL and GPNMB Family Proteins
Molecules, 2021 The ancient paralogs premelanosome protein (PMEL) and glycoprotein nonmetastatic melanoma protein B (GPNMB) have independently emerged as intriguing disease loci in recent years.
Paul W. Chrystal +5 more
doaj +1 more source
Cold Spring Harbor Perspectives in Biology, 2019 When protein/peptides aggregate, they usually form the amyloid state consisting of cross β-sheet structure built by repetitively stacked β-strands forming long fibrils. Amyloids are usually associated with disease including Alzheimer's. However, amyloid has many useful features.
Otzen, Daniel, Riek, Roland
openaire +3 more sources
Innovative surface bio-functionalization by fungal hydrophobins and their engineered variants
Frontiers in Molecular Biosciences, 2022 Research on innovative surface functionalization strategies to develop materials with high added value is particularly challenging since this process is a crucial step in a wide range of fields (i.e., biomedical, biosensing, and food packaging).
Ilaria Stanzione +5 more
doaj +1 more source
The amphibian antimicrobial peptide uperin 3.5 is a cross-α/cross-β chameleon functional amyloid. [PDF]
Proc Natl Acad Sci U S A, 2021 Salinas N +7 more
europepmc +2 more sources
Fibrilar Polymorphism of the Bacterial Extracellular Matrix Protein TasA
Microorganisms, 2021 Functional amyloid proteins often appear as fibers in extracellular matrices of microbial soft colonies. In contrast to disease-related amyloid structures, they serve a functional goal that benefits the organism that secretes them, which is the reason ...
Mnar Ghrayeb +4 more
doaj +1 more source
Anti-Biofilm Molecules Targeting Functional Amyloids [PDF]
Antibiotics, 2021 The choice of an effective therapeutic strategy in the treatment of biofilm-related infections is a significant issue. Amyloids, which have been historically related to human diseases, are now considered to be prevailing structural components of the biofilm matrix in a wide range of bacteria.
Leticia Matilla-Cuenca +2 more
openaire +6 more sources
Functional Amyloids in Reproduction [PDF]
Biomolecules, 2017 Amyloids are traditionally considered pathological protein aggregates that play causative roles in neurodegenerative disease, diabetes and prionopathies. However, increasing evidence indicates that in many biological systems nonpathological amyloids are formed for functional purposes.
Hewetson, Aveline +6 more
openaire +2 more sources