Results 21 to 30 of about 304,354 (194)

Sticking to the Subject: Multifunctionality in Microbial Adhesins

Journal of Fungi, 2023
Bacterial and fungal adhesins mediate microbial aggregation, biofilm formation, and adhesion to host. We divide these proteins into two major classes: professional adhesins and moonlighting adhesins that have a non-adhesive activity that is ...
Peter N. Lipke, Peleg Ragonis-Bachar
doaj   +1 more source

Zinc–dysprosium functionalized amyloid fibrils [PDF]

Dalton Transactions, 2019
The heterometallic Zn2Dy2 entity bearing partially saturated metal centres covalently decorates a highly ordered amyloid fibril core and the functionalised assembly exhibits catalytic Lewis acid behaviour.
Stavroula I. Sampani, Youssra K. Al-Hilaly, Sharali Malik, Louise C. Serpell, George E. Kostakis   +4 more
openaire   +3 more sources

The relationship between amyloid structure and cytotoxicity [PDF]

, 2014
Self-assembly of proteins and peptides into amyloid structures has been the subject of intense and focused research due to their association with neurodegenerative, age-related human diseases and transmissible prion diseases in humans and mammals. Of the
Marchante, Ricardo, Marshall, Karen E, Serpell, Louise C, Xue, Wei-Feng   +3 more
core   +1 more source

Serum Amyloid P Component Binds Fungal Surface Amyloid and Decreases Human Macrophage Phagocytosis and Secretion of Inflammatory Cytokines

mBio, 2019
In patients with invasive fungal diseases, there is often little cellular inflammatory response. We tested the idea that binding of the human constitutive plasma protein serum amyloid P component (SAP) (also called PTX2) to Candida albicans dampens the ...
Nicole E. Behrens, Peter N. Lipke, Darrell Pilling, Richard H. Gomer, Stephen A. Klotz   +4 more
doaj   +1 more source

Bayesian latent time joint mixed-effects model of progression in the Alzheimer's Disease Neuroimaging Initiative. [PDF]

, 2018
IntroductionWe characterize long-term disease dynamics from cognitively healthy to dementia using data from the Alzheimer's Disease Neuroimaging Initiative.MethodsWe apply a latent time joint mixed-effects model to 16 cognitive, functional, biomarker ...
Aisen, Paul S, Donohue, Michael C, Iddi, Samuel, Li, Dan, Rafii, Michael S, Thompson, Wesley K   +5 more
core   +1 more source

Modulating Kinetics of the Amyloid-Like Aggregation of S. aureus Phenol-Soluble Modulins by Changes in pH

Microorganisms, 2021
The pathogen Staphylococcus aureus is recognized as one of the most frequent causes of biofilm-associated infections. The recently identified phenol-soluble modulin (PSM) peptides act as the key molecular effectors of staphylococcal biofilm maturation ...
Masihuz Zaman, Maria Andreasen
doaj   +1 more source

Early affective changes and increased connectivity in preclinical Alzheimer's disease. [PDF]

, 2018
IntroductionAffective changes precede cognitive decline in mild Alzheimer's disease and may relate to increased connectivity in a "salience network" attuned to emotionally significant stimuli.
Bilgel, Murat, Brown, Jesse A, Fredericks, Carolyn A, Hua, Alice Y, Resnick, Susan M, Seeley, William W, Sturm, Virginia E, Wong, Dean F   +7 more
core   +1 more source

Unzipping a Functional Microbial Amyloid [PDF]

ACS Nano, 2012
Bacterial and fungal species produce some of the best-characterized functional amyloids, that is, extracellular fibres that play key roles in mediating adhesion and biofilm formation. Yet, the molecular details underlying their mechanical strength remain poorly understood.
David, Alsteens, Caleen B, Ramsook, Peter N, Lipke, Yves F, Dufrêne   +3 more
openaire   +2 more sources

Functional Amyloids Signal Their Arrival [PDF]

Science Signaling, 2009
Several peptide and protein hormones are stored in an amyloid configuration in secretory granules.
Matthew P, Badtke, Neal D, Hammer, Matthew R, Chapman   +2 more
openaire   +2 more sources

Genes Involved in Biofilm Matrix Formation of the Food Spoiler Pseudomonas fluorescens PF07

Frontiers in Microbiology, 2022
The extracellular matrix is essential for the biofilm formation of food spoilers. Pseudomonas fluorescens PF07 is a previous isolate from spoiled marine fish; however, the genes involved in the extracellular matrix formation of PF07 biofilms remain ...
Miao Guo, Miao Guo, Siqi Tan, Siqi Tan, Junli Zhu, Aihua Sun, Peng Du, Xiaoxiang Liu   +7 more
doaj   +1 more source