Results 181 to 190 of about 40,710 (290)

Review Article: Targeting Peroxisome Proliferator‐Activated Receptors in Primary Biliary Cholangitis

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 9, Page 1215-1235, May 2026.
Peroxisome proliferator‐activated receptor (PPAR) agonists have emerged as important second‐line treatments in primary biliary cholangitis, with profiles influenced by different selectivity for α‐, δ‐ and γ‐isoforms. PPAR‐α and PPAR‐δ agonism improve cholestasis, with inflammation reduced via all isoforms. PPAR‐δ agonism also reduces pruritus.
Jörn M. Schattenberg, Jesus M. Banales, Gideon Hirschfield, Palak Trivedi, Edward E. Cable, Charles A. McWherter, Andrew N. Billin, Daria B. Crittenden, Grant Budas   +8 more
wiley   +1 more source

Caffeic acid phenethyl ester suppresses intestinal FXR signaling and ameliorates nonalcoholic fatty liver disease by inhibiting bacterial bile salt hydrolase activity

Acta Pharmacologica Sinica, 2022
Xianchun Zhong, Ya-meng Liu, XiaoXia Gao, K. Krausz, B. Niu, F. Gonzalez, Cen Xie   +6 more
semanticscholar   +1 more source

Using Multiple Diagnostic Methods for Occupational Asthma Assessment

The Clinical Respiratory Journal, Volume 20, Issue 5, May 2026.
PC20 variability demonstrated higher diagnostic accuracy than PEFR monitoring in occupational asthma (OA), with a sensitivity of 90% and specificity of 92%. PEFR alone resulted in a 22.2% misclassification rate. Incorporating PC20 variability into diagnostic evaluation may reduce misdiagnosis and improve clinical outcomes in high‐exposure settings ...
Bilge Akgündüz, Günhan Yavaşoğlu
wiley   +1 more source

Probiotic‐derived nanoparticles inhibit ALD through intestinal miR194 suppression and subsequent FXR activation

Hepatology, 2022
Mengwei Jiang, Fengyuan Li, Yunhuan Liu, Zelin Gu, Lihua Zhang, JiYeonn Lee, Liqing He, V. Vatsalya, Huang‐Ge Zhang, Zhong‐bin Deng, Xiang Zhang, Shao-yu Chen, G. Guo, S. Barve, C. McClain, Wenke Feng   +15 more
semanticscholar   +1 more source

Comparison of serum Farnesoid X Receptor (FXR) levels and their associations with obesity-related metabolic parameters: a clinical study. [PDF]

BMC Endocr Disord
Yuksel Salduz ZI, Turgut R, Coskun ZS, Pasin O, Kartal M, Ozder A.   +5 more
europepmc   +1 more source

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis.

Molecules and Cells, 2000
B. Goodwin, Stacey A. Jones, R. R. Price, M. Watson, D. D. Mckee, L. Moore, C. Galardi, Joan G. Wilson, M. Lewis, M. Roth, P. Maloney, T. Willson, S. Kliewer   +12 more
semanticscholar   +1 more source

Activation of Brown Adipocytes by Farnesoid X Receptor Agonist, Obeticholic Acid-A Potential Novel Therapeutic Avenue in the Management of Obesity. [PDF]

J Clin Med
Dąbrowska AM, Chwil M, Urbańska EM.
europepmc   +1 more source

Inhibition of the Primary Bile Acid Synthesis Pathways in SD Rats at Different Altitudes. [PDF]

Animals (Basel)
Ma P, Hu Q, Ma F, Zhang W, Gu H, Wei D, An Z.   +6 more
europepmc   +1 more source

Research progress on the role of bile acid metabolism in intestinal epithelial cell injury in necrotizing enterocolitis. [PDF]

Front Pediatr
Zhang S, Li G, Tian Y, Liu Q.
europepmc   +1 more source

Effects of Guanxinning tablet on the gut microbiota and bile acid metabolism in mice with hyperlipidemia. [PDF]

Front Pharmacol
Li X, Ma J, Wang Y, Li X, Zhu C.
europepmc   +1 more source