Brain GABA and Glutamate Concentrations Following Chronic Gabapentin Administration: A Convenience Sample Studied During Early Abstinence From Alcohol. [PDF]
, 2018 Gabapentin (GBP), a GABA analog that may also affect glutamate (Glu) production, can normalize GABA and Glu tone during early abstinence from alcohol, effectively treating withdrawal symptoms and facilitating recovery.
Durazzo, Timothy C +3 more
core +2 more sources
Management of Widespread Pain and Fibromyalgia [PDF]
, 2016 Peer reviewedPublisher ...
Basu, Neil +2 more
core +2 more sources
Journal of Pharmacological Sciences, 2009 Gabapentin was developed as an anticonvulsant, but has also been used to alleviate hyperalgesia in neuropathic pain. In this study, the protective effect of gabapentin against N-methyl-D-aspartate (NMDA)-induced excitotoxicity in rat hippocampal CA1 ...
Young-Sick Kim +9 more
doaj +1 more source
Gabapentin for pain management after osmotic dilator insertion and prior to dilation and evacuation: A randomized controlled trial. [PDF]
, 2020 ObjectiveTo evaluate if gabapentin 600 mg reduces pain after osmotic dilator placement the day before a dilation and evacuation (D&E) procedure.Study designWe conducted a double-blind, placebo-controlled, randomized (stratified by vaginal parity ...
Chen, Melissa J +5 more
core +3 more sources
Evaluation and Management of Sleep Disorders in the Hand Surgery Patient. [PDF]
, 2016 Despite posing a significant public health threat, sleep disorders remain poorly understood and often underdiagnosed and mismanaged. Although sleep disorders are seemingly unrelated, hand surgeons should be mindful of these because numerous conditions of
Gaspar, Michael P. +4 more
core +2 more sources
Antinociceptive activity of the S1P-receptor agonist FTY720 [PDF]
, 2008 FTY720 is a novel immunosuppressive drug that inhibits the egress of lymphocytes from secondary lymphoid tissues and thymus. In its phosphorylated form FTY720 is a potent S1P receptor agonist.
Angioni, Carlo Federico +8 more
core +1 more source
Genitofemoral neuralgia : adding to the burden of chronic vulvar pain [PDF]
, 2015 The vulva is a particularly common locus of chronic pain with neuropathic characteristics that occurs in women of any age, though most women with neuropathic type chronic vulvar pain will remain undiagnosed even following multiple physician visits. Here,
De Muynck, Martine +2 more
core +2 more sources
Siriraj Medical Journal, 2020 Background: Neuropathic pain (NP) develops as a consequence of a lesion or disease affecting the somatosensory system. Patients with severe NP usually suffer from pain and may need many treatment options.
Rungsan Chaisewikul +3 more
doaj
Combination of pharmacotherapy and lidocaine analgesic block of the peripheral trigeminal branches for trigeminal neuralgia: a pilot study [PDF]
, 2015 Classical trigeminal neuralgia (CTN) is treated predominantly by pharmacotherapy but side effects and unsuccessful occurs. The current study was carried out to evaluate the therapeutic effect of combination of pharmacotherapy and lidocaine block ...
Bruti, Gianluca +9 more
core +3 more sources
Challenges recruiting to a proof-of-concept pharmaceutical trial for a rare disease: The trigeminal neuralgia experience [PDF]
, 2018 Background: This study aimed to describe recruitment challenges encountered during a phase IIa study of vixotrigine, a state and use-dependent Nav1.7 channel blocker, in individuals with trigeminal neuralgia.
Bendtsen, Lars +10 more
core +4 more sources