Results 11 to 20 of about 17,093 (242)

Production of α-Galactosylceramide by a Prominent Member of the Human Gut Microbiota [PDF]

PLoS Biology, 2013
While the human gut microbiota are suspected to produce diffusible small molecules that modulate host signaling pathways, few of these molecules have been identified.
Bluestone, Jeffrey A., Clardy, Jon, Comstock, Laurie E., Fischbach, Michael A., Kashyap, Purna C., Kronenberg, Mitchell, Penaranda, Cristina, Sonnenburg, Justin L., Wieland Brown, Laura C., Williams, Brianna B.   +9 more
core   +5 more sources

Galactosylceramide affects tumorigenic and metastatic properties of breast cancer cells as an anti-apoptotic molecule. [PDF]

PLoS ONE, 2013
It was recently proposed that UDP-galactose:ceramide galactosyltransferase (UGT8), enzyme responsible for synthesis of galactosylceramide (GalCer), is a significant index of tumor aggressiveness and a potential marker for the prognostic evaluation of ...
Tomasz B Owczarek, Jarosław Suchanski, Bartosz Pula, Alicja M Kmiecik, Marek Chadalski, Aleksandra Jethon, Piotr Dziegiel, Maciej Ugorski   +7 more
doaj   +2 more sources

Glucosylceramide and galactosylceramide, small glycosphingolipids with significant impact on health and disease

Glycobiology, 2021
Numerous clinical observations and exploitation of cellular and animal models indicate that glucosylceramide (GlcCer) and galactosylceramide (GalCer) are involved in many physiological and pathological phenomena.
Safoura Reza, M. Ugorski, J. Suchański
semanticscholar   +1 more source

Development of a Self-Adjuvanting Influenza Peptide-Glycolipid Conjugate Inducing CD8⁺ T-Cell Immunity. [PDF]

Chembiochem
The glycolipid‐peptide antigen complexes for self‐adjuvanting conjugates were successfully synthesized, and, with the HLA‐transgenic mice, the antigen‐specific CD8+ T cell expansion was exhibited. The results provide useful insights for the design and synthesis of vaccine conjugates using glycolipid antigen as an adjuvant.
Kikuchi S, Ogura H, Matsumaru T, Ishido S, Fujimoto Y.   +4 more
europepmc   +2 more sources

Two bacterial glycosphingolipid synthases responsible for the synthesis of glucuronosylceramide and α-galactosylceramide

Journal of Biological Chemistry, 2020
Bacterial glycosphingolipids such as glucuronosylceramide and galactosylceramide have been identified as ligands for invariant natural killer T cells and play important roles in host defense.
N. Okino, M. Li, Qingjun Qu, T. Nakagawa, Y. Hayashi, M. Matsumoto, Yohei Ishibashi, Makoto Ito   +7 more
semanticscholar   +1 more source

Qualitative and Quantitative Study of Glycosphingolipids in Human Milk and Bovine Milk Using High Performance Liquid Chromatography–Data-Dependent Acquisition–Mass Spectrometry

Molecules, 2020
Cerebrosides (Crb; including glucosylceramide and galactosylceramide) and lactosylceramide (LacCer) are structurally complex lipids found in many eukaryotic cell membranes, where they play important roles in cell growth, apoptosis, cell recognition and ...
Lin Ma, Bertram Y. Fong, Alastair K. H. MacGibbon, Gillian Norris   +3 more
doaj   +1 more source

Kidney lipids in galactosylceramide synthase-deficient mice: absence of galactosylsulfatide and compensatory increase in more polar sulfoglycolipids1

Journal of Lipid Research, 2000
UDP-galactose:ceramide galactosyltransferase (CGT) catalyzes the final step in the synthesis of galactosylceramide (GalCer). It has previously been shown that CGT-deficient mice do not synthesize GalCer and its sulfated derivative GalCer I3-sulfate ...
Keiko Tadano-Aritomi, Toshiyuki Hikita, Hirokazu Fujimoto, Kunihiko Suzuki, Kohji Motegi, Ineo Ishizuka   +5 more
doaj   +1 more source

α-Galactosylceramide: a potent immunomodulator produced by gut microbes1 [PDF]

Journal of Lipid Research, 2019
Rotonya M. Carr
doaj   +3 more sources

Stereochemical structures of synthesized and natural plasmalogalactosylceramides from equine brain

Journal of Lipid Research, 1998
Modified galactosylceramide with a long-chain cyclic acetal at the sugar moiety, plasmalogalactosylceramide, was isolated from equine brain. To identify the isomeric stereostructure of the natural product, the plasmalo derivative was chemically ...
Youichi Yachida, Motoi Kashiwagi, Takeshi Mikami, Keiko Tsuchihashi, Takumi Daino, Toyoaki Akino, Shinsei Gasa   +6 more
doaj   +1 more source

Tailored design of NKT-stimulatory glycolipids for polarization of immune responses. [PDF]

, 2017
Natural killer T (NKT) cell is a distinct population of T lymphocytes that can rapidly release massive amount of Th1 and Th2 cytokines upon the engagement of their T cell receptor with glycolipids presented by CD1d.
Huang, Jing-Rong, Hung, Jung-Tung, Yu, Alice L   +2 more
core   +2 more sources