Results 21 to 30 of about 17,093 (242)

Activation of iNKT Cells Prevents Salmonella-Enterocolitis and Salmonella-Induced Reactive Arthritis by Downregulating IL-17-Producing γδT Cells [PDF]

, 2017
Reactive arthritis (ReA) is an inflammatory condition of the joints that arises following an infection. Salmonella enterocolitis is one of the most common infections leading to ReA.
Aya Castañeda, Maria del Rosario, Blanco, Guillermo Armando C., Cerquetti, Maria Cristina, Giacomodonato, Mónica Nancy, Morales, Andrea Lorena, Noto Llana, Mariangeles, Sarnacki, Sebastian Hernan   +6 more
core   +1 more source

FA2H-dependent fatty acid 2-hydroxylation in postnatal mouse brain

Journal of Lipid Research, 2006
2-Hydroxy fatty acids are relatively minor species of membrane lipids found almost exclusively as N-acyl chains of sphingolipids. In mammals, 2-hydroxy sphingolipids are uniquely abundant in myelin galactosylceramide and sulfatide.
Nathan L. Alderson, Eduardo N. Maldonado, Michael J. Kern, Narayan R. Bhat, Hiroko Hama   +4 more
doaj   +1 more source

Sulfatide inhibits  -galactosylceramide presentation by dendritic cells [PDF]

International Immunology, 2012
Sulfatide-reactive type II NKT cells, the so-called non-invariant NKT (non-iNKT) cells, have been shown to counteract invariant NKT (iNKT) cell activity. However, the effects of sulfatide on activation of iNKT cells by α-galactocylceramide (αGC) in the context of CD1d have not been studied in detail.
Mitsuhiro, Kanamori, Yusuke, Tasumi, Tomonori, Iyoda, Maki, Ushida, Kayo, Inaba   +4 more
openaire   +2 more sources

Quantitative analysis of brain galactosylceramides by high performance liquid chromatography of their perbenzoyl derivatives

Journal of Lipid Research, 1976
A high performance liquid chromatographic (HPLC) method for analysis of galactosylceramides as their benzoyl derivatives has been devised. Samples containing 10-150 nmoles of monohexosylceramides are benzoylated by heating for 60 min at 60 ° C in 0.5 ml ...
E H McCluer, J E Evans
doaj   +1 more source

C-galactosylceramide: Synthesis and immunology [PDF]

Comptes Rendus. Chimie, 2011
A synthetic C-glycoside, α-C-galactosylceramide, is an active immunostimulant in mice. It displays better activity than α-O-galactosylceramide in several disease models. Syntheses of several α-C-galactosylceramides are described. Experiments that probe its immunostimulant activity are outlined.
openaire   +2 more sources

Codelivery of mRNA with α-Galactosylceramide Using a New Lipopolyplex Formulation Induces a Strong Antitumor Response upon Intravenous Administration

ACS Omega, 2019
Recently, the use of mRNA-based vaccines for cancer immunotherapy has gained growing attention. Several studies have shown that mRNA delivered in a vectorized format can generate a robust and efficient immune response.
M. Guevara, Zachary K. Jilesen, D. Stojdl, S. Persano   +3 more
semanticscholar   +1 more source

Reduced chain length in myelin sphingolipids and poorer motor coordination in mice deficient in the fatty acid elongase Elovl1

FASEB BioAdvances, 2019
Very‐long‐chain fatty acids, with a chain length of >C20, are abundant in myelin sphingolipids. Recently, a de novo mutation in the ELOVL1 gene, which encodes fatty acid elongase, was identified in patients with neurocutaneous disorders involving skin ...
Masashi Isokawa, Takayuki Sassa, Satoko Hattori, Tsuyoshi Miyakawa, Akio Kihara   +4 more
doaj   +1 more source

Neutral glycosphingolipids in human blood: a precise mass spectrometry analysis with special reference to lipoprotein-associated Shiga toxin receptors[S]

Journal of Lipid Research, 2010
Shiga toxin (Stx)-producing Escherichia coli are the leading cause of hemorrhagic colitis and life-threatening extraintestinal complications in humans. Stx1 and Stx2 are transferred by yet to be delineated mechanisms from the intestine to the circulation
Christian H. Schweppe, Petra Hoffmann, Jerzy-Roch Nofer, Gottfried Pohlentz, Michael Mormann, Helge Karch, Alexander W. Friedrich, Johannes Müthing   +7 more
doaj   +1 more source

Porcine intestinal glycosphingolipids recognized by F6-fimbriated enterotoxigenic Escherichia coli [PDF]

, 2014
One important virulence factor of enterotoxigenic Escherichia coli is their ability to adhere via fimbrial adhesins to specific receptors located on the intestinal mucosa. Here, the potential glycosphingolipid receptors of enterotoxigenic F6-fimbriated E.
Benktander, John, Coddens, Annelies, Cox, Eric, Johansson, Miralda Madar, Teneberg, Susann   +4 more
core   +2 more sources

An oral alpha-galactosylceramide adjuvanted Helicobacter pylori vaccine induces protective IL-1R- and IL-17R-dependent Th1 responses

npj Vaccines, 2019
Helicobacter pylori causes chronic gastric infection that can lead to peptic ulcers and is an identified risk factor for gastric cancer development. Although much effort has been put into the development of a Helicobacter pylori vaccine over the last ...
Stephanie Longet, Á. Abautret-Daly, C. Davitt, Craig P. McEntee, V. Aversa, M. Rosa, I. Coulter, J. Holmgren, S. Raghavan, E. Lavelle   +9 more
semanticscholar   +1 more source