Results 41 to 50 of about 17,093 (242)

Detergents alter the stability and lipid binding properties of the CD1d immunoreceptor. [PDF]

Protein Sci
Abstract CD1d, a non‐classical immunoreceptor, plays a central role in lipid antigen presentation to a variety of T cell types. Despite the widespread use of detergents to measure and manipulate lipid/CD1d interactions in vitro, in situ, and in vivo, the molecular basis by which detergents influence the stability of CD1d and its lipid binding ...
Miles UZ, Finn MG, McShan AC.
europepmc   +2 more sources

Structural determination of lipid antigens captured at the CD1d-T-cell receptor interface [PDF]

, 2017
Glycolipid antigens recognized by αβ T-cell receptors (TCRs) drive the activation of invariant natural killer T (iNKT) cells, a specialized subset of innate T lymphocytes.
Burdin, D. Branch Moody, Dale I. Godfrey, Daniel G. Pellicci, David C. Young, Gerald F. M. Watts, Gurdyal S. Besra, Jamie Rossjohn, Kanie, Michael B. Brenner, Natacha Veerapen, Patrick J. Brennan, Tan-Yun Cheng   +12 more
core   +2 more sources

C-Galactosylceramide diastereomers via Sharpless asymmetric epoxidation chemistry [PDF]

Tetrahedron, 2008
Abstract C-Glycoside analogs of α-galactosylceramide (KRN7000) were synthesized in 19 linear steps with Sharpless asymmetric epoxidation as a key reaction. Opening of a hydroxy epoxide with sodium azide provided an anti vicinal azido diol with inversion of configuration at the azide-bearing carbon while opening with Ti(O-i-Pr)2(N3)2 gave syn vicinal ...
Jun, Pu, Richard W, Franck
openaire   +2 more sources

FA2H is responsible for the formation of 2-hydroxy galactolipids in peripheral nervous system myelins⃞

Journal of Lipid Research, 2008
Myelin in the mammalian nervous system has a high concentration of galactolipids [galactosylceramide (GalCer) and sulfatide] with 2-hydroxy fatty acids.
Eduardo N. Maldonado, Nathan L. Alderson, Paula V. Monje, Patrick M. Wood, Hiroko Hama   +4 more
doaj   +1 more source

Sex differences in gene expression with galactosylceramide treatment in Cln3Δex7/8 mice

PLoS ONE, 2020
Background CLN3 disease is caused by mutations in the CLN3 gene. The purpose of this study is to discern global expression patterns reflecting therapeutic targets in CLN3 disease.
Joelle Makoukji, Sally El-Sitt, Nadine J. Makhoul, Jihane Soueid, Humam Kadara, Rose-Mary Boustany, Francisco J. Esteban   +6 more
doaj   +2 more sources

Natural killer cells in placentation and cancer: Implications for hypertension during pregnancy [PDF]

, 2017
Hypertension during pregnancy is the most common medical condition encountered during gestation. Despite this, knowledge of the mechanisms that underlie the disease and the development of new therapies are limited.
Cornelius, Denise C., Delles, Christian, Guzik, Tomasz J., Small, Heather Yvonne   +3 more
core   +1 more source

Efficient Divergent Synthesis of New Immunostimulant 4″-Modified α-Galactosylceramide Analogues

ACS Medicinal Chemistry Letters, 2017
A synthesis strategy for the swift generation of 4″-modified α-galactosylceramide (α-GalCer) analogues is described, establishing a chemical platform to comprehensively investigate the structure–activity relationships (SAR) of this understudied ...
J. Janssens, T. Decruy, K. Venken, T. Seki, Simon Krols, J. Van der Eycken, M. Tsuji, D. Elewaut, S. van Calenbergh   +8 more
semanticscholar   +1 more source

Characterization and direct quantitation of cerebroside molecular species from lipid extracts by shotgun lipidomics

Journal of Lipid Research, 2005
By using shotgun lipidomics based on the separation of lipid classes in the electrospray ion source (intrasource separation) and two-dimensional (2D) MS techniques (Han, X., and R. W. Gross. 2004.
Xianlin Han, Hua Cheng
doaj   +1 more source

Synthesis and structure-activity relationships of cerebroside analogues as substrates of cerebroside sulphotransferase and discovery of a competitive inhibitor

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Metachromatic leukodystrophy (MLD) is a rare genetic disease characterised by a dysfunction of the enzyme arylsulphatase A leading to the lysosomal accumulation of cerebroside sulphate (sulphatide) causing subsequent demyelination in patients. The enzyme
Wenjin Li, Joren Guillaume, Younis Baqi, Isabell Wachsmann, Volkmar Gieselmann, Serge Van Calenbergh, Christa E. Müller   +6 more
doaj   +1 more source

Alpha-galactosylceramide improves the potency of mRNA LNP vaccines against cancer and intracellular bacteria.

Journal of Controlled Release
Although various types of mRNA-based vaccines have been explored, the optimal conditions for induction of both humoral and cellular immunity remain rather unknown.
Sofie Meulewaeter, Ilke Aernout, J. Deprez, Y. Engelen, Margo De Velder, Lorenzo Franceschini, K. Breckpot, Serge Van Calenbergh, Caroline Asselman, Katie Boucher, F. Impens, S. D. De Smedt, Rein Verbeke, I. Lentacker   +13 more
semanticscholar   +1 more source