Differentiation of IL-17-Producing Invariant Natural Killer T Cells Requires Expression of the Transcription Factor c-Maf [PDF]
, 2017 journal ...
HAMADA Michito +5 more
core +1 more source
Journal of Biomedical Sciences, 2016 BackgroundDNA vaccines have emerged as an attractive approach for the generation of cytotoxic T lymphocytes (CTL). In our previous study, we found That Toll like receptor (TLR) ligands are promising candidates for the development of novel adjuvants for ...
Fateme Gableh +6 more
semanticscholar +1 more source
Diastereomer-specific quantification of bioactive hexosylceramides from bacteria and mammals[S]
Journal of Lipid Research, 2017 Mammals synthesize, cell-type specifically, the diastereomeric hexosylceramides, β-galactosylceramide (GalCer) and β-glucosylceramide (GlcCer), which are involved in several diseases, such as sphingolipidosis, diabetes, chronic kidney diseases, or cancer.
Johanna von Gerichten +9 more
doaj +1 more source
An optimized method for isolating and expanding invariant natural killer T cells from mouse spleen [PDF]
, 2015 The ability to rapidly secrete cytokines upon stimulation is a functional characteristic of the invariant natural killer T (iNKT) cell lineage. iNKT cells are therefore characterized as an innate T cell population capable of activating and steering ...
Drennan, Michael +2 more
core +1 more source
Scientific Reports, 2016 Natural killer T (NKT) -cells activated with the glycolipid ligand α-galactosylceramide (α-GalCer) stimulate a wide array of immune responses with many promising immunotherapeutic applications, including the enhancement of vaccines against infectious ...
B. L. Artiaga +8 more
semanticscholar +1 more source
Macrophage transactivation for chemokine production identified as a negative regulator of granulomatous inflammation using agent-based modeling [PDF]
, 2018 Cellular activation in trans by interferons, cytokines and chemokines is a commonly recognized mechanism to amplify immune effector function and limit pathogen spread. However, an optimal host response also requires that collateral damage associated with
Andrews, Paul S. +8 more
core +5 more sources
NKT TCR Recognition of CD1d-α-C-Galactosylceramide [PDF]
The Journal of Immunology, 2011 Abstract NKT cells respond to a variety of CD1d-restricted glycolipid Ags that are structurally related to the prototypic Ag α-galactosylceramide (α-GalCer). A modified analog of α-GalCer with a carbon-based glycosidic linkage (α-C-GalCer) has generated great interest because of its apparent ability to promote prolonged, Th1-biased ...
Patel, Onisha +14 more
openaire +3 more sources
Krabbe disease: a galactosylsphingosine (psychosine) lipidosis.
Journal of Lipid Research, 1980 The primary genetic defect underlying Krabbe disease or globoid cell leukodystrophy is considered to be a deficiency of galactosylceramide-beta-galactosidase.
L Svennerholm, M T Vanier, J E Månsson
doaj +1 more source
Targeting Sphingolipids for Cancer Therapy
Frontiers in Oncology, 2021 Sphingolipids are an extensive class of lipids with different functions in the cell, ranging from proliferation to cell death. Sphingolipids are modified in multiple cancers and are responsible for tumor proliferation, progression, and metastasis ...
Osmel Companioni +4 more
doaj +1 more source
Activation of Invariant NKT Cells with Glycolipid Ligand α-Galactosylceramide Ameliorates Glucose-6-Phosphate Isomerase Peptide-Induced Arthritis [PDF]
, 2012 ObjectiveInvariant natural killer T (iNKT) cells regulate collagen-induced arthritis (CIA) when activated by their potent glycolipid ligand, alpha-galactosylceramide (α-GalCer).
Goto Daisuke +13 more
core +1 more source