Results 71 to 80 of about 17,093 (242)
Efficient synthesis of α-galactosylceramide and its C-6 modified analogs
Frontiers in Chemistry, 2022 The synthesis of α-galactosylceramide (KRN7000) and its C-6 modified analogs remains a challenge due to the difficult α-1,2-cis-glycosidic bond. A non-participating benzyl (Bn) protecting group has been commonly used to favor the α-glycosylation product.
Huiting Li +6 more
doaj +1 more source
Immune cells and preterm labour:do invariant NKT cells hold the key? [PDF]
, 2015 We have developed our original made-to-measure (M2M) algorithm, PRIMAL, with the aim of modelling the Galactic disc from upcoming Gaia data. From a Milky Way like N-body disc galaxy simulation, we have created mock Gaia data using M0III stars as tracers,
Rinaldi, S F +3 more
core +3 more sources
Organoids for Metabolic Disease Modeling
Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.ABSTRACT Inherited metabolic diseases (IMDs) are a diverse group of rare genetic disorders that disrupt metabolic pathways, leading to severe clinical manifestations. Disease models ranging from complex animal models to simple in vitro systems have provided insights into IMDs, but each has limitations.
Arif Ibrahim Ardisasmita +2 more
wiley +1 more source
Journal of Lipid Research, 1992 For preparation of an affinity ligand, an N-fatty acyl moiety of galactosylceramide (GalCer) was chemically replaced with omega-amino-fatty acid including amino-n-hexanoic acid or amino-n-dodecanoic acid to obtain omega-aminoGalCer.
K Kamio, S Gasa, A Makita
doaj +1 more source
Genetic Regulation of NKT Cell Function [PDF]
, 2017 NKT cells are specialized T cells that play important roles in the host immune response to bacteria and viruses. NKT cells produce a wide variety of cytokines and chemokines after being activated by glycolipids such as α-galactosylceramide (αGalCer ...
Malagic, Murisa
core +1 more source
Does an NKT-cell-based immunotherapeutic approach have a future in multiple myeloma? [PDF]
, 2016 Natural killer T (NKT) cells constitute a unique subset of innate-like T lymphocytes which differ from conventional T cells by recognizing lipid antigens presented by the non-polymorphic major histocompatibility complex (MHC) I-like molecule CD1d ...
Elewaut, Dirk +4 more
core +2 more sources
Immunology &Cell Biology, Volume 104, Issue 2, Page 109-124, February 2026.In this study, we characterize a distinct subpopulation of undifferentiated invariant natural killer T (iNKT) cells in the peripheral blood of healthy adults, which are characterized by CD38 expression in a resting state. This CD38+ subset closely resembles iNKT cells from cord blood and thymus, exhibiting a unique cytokine profile and alterations in ...
Christopher Menne +13 more
wiley +1 more source
A New Possible Mechanism of Human Immunodeficiency Virus Type 1 Infection of Neural Cells
Neurobiology of Disease, 2002 To study the mechanism by which HIV-1 infects neurons we have used human neuroblastoma cell lines (NB). NB (SK-N-SH and SK-N-MC) were found to be susceptible to productive infection by X4 or R5 HIV-1, as detected by viral load and Ag-p24. To identify the
Susana Álvarez Losada +2 more
doaj +1 more source
Mutation of the Traj18 gene segment using TALENs to generate Natural Killer T cell deficient mice. [PDF]
, 2016 Invariant Natural Killer T (iNKT) cells are a unique subset of T lymphocytes that have been implicated in both promoting and suppressing a multitude of immune responses. In mice, iNKT cells express T cell antigen receptors (TCRs) comprising a unique TCRα
Bedel, R. +7 more
core +1 more source
Journal of Experimental Medicine, 1999 The natural killer T (NKT) cell ligand α-galactosylceramide (α-GalCer) exhibits profound antitumor activities in vivo that resemble interleukin (IL)-12–mediated antitumor activities. Because of these similarities between the activities of α-GalCer and IL-
H. Kitamura +12 more
semanticscholar +1 more source