Results 91 to 100 of about 20,179 (201)

Peptides binding cocaine: A strategy to design biomimetic receptors [PDF]

, 2013
A computational methodology for designing and rationalizing the selection of small peptides as biomimetic receptors for cocaine is proposed. The method started by searching and filtering proteins X-ray and NMR data of biological receptor-cocaine ...
Compagnone, Dario, Curini, Roberta, Del Carlo, Michele, Mascini, Marcello, Montero-Cabrera, Luis Alberto, Perez, German, Sergi, Manuel   +6 more
core   +1 more source

Investigation of Thiazolidine‐2,4‐Dione Derivatives as Acetylcholinesterase Inhibitors: Synthesis, In Vitro Biological Activities and In Silico Studies

ChemistryOpen, Volume 14, Issue 5, May 2025.
Thiazolidin‐2,4‐dion derivatives were synthesized and evaluated for drug‐likeness, BBB permeability, and ADMET properties. Docking studies revealed that all derivatives (CHT1‐5) had good AChE inhibition, although CHT1 was the most effective and showed strong antioxidant activity in vitro.
Hanane Naeimi, Maryam Taheri, Hossein Ghafouri, Asadollah Mohammadi   +3 more
wiley   +1 more source

Memantine and Cholinesterase Inhibitors: Complementary Mechanisms in the Treatment of Alzheimer’s Disease [PDF]

, 2013
This review describes the preclinical mechanisms that may underlie the increased therapeutic benefit of combination therapy—with the N-methyl-d-aspartate receptor antagonist, memantine, and an acetylcholinesterase inhibitor (AChEI)—for the treatment of ...
Andrzej Dekundy, Chris G. Parsons, Irena Pulte, Wojciech Danysz   +3 more
core   +1 more source

A Computational Approach to Identify Novel Protein Targets Uncovers New Potential Mechanisms of Action of Mirtazapine S(+) and R(−) Enantiomers in Rett Syndrome

Journal of Neurochemistry, Volume 169, Issue 5, May 2025.
Computational pipeline to identify potential drug targets and pathways for Rett syndrome, by analyzing ligand‐bound pockets and predicted drug affinities. ABSTRACT Rett syndrome (RTT) is a progressive neurodevelopmental disorder that affects approximately 1:10000 newborn girls and is primarily caused by mutations in the X‐linked gene MECP2.
Ottavia Maria Roggero, Nicolò Gualandi, Viviana Ciraci, Vittoria Berutto, Emanuele Carosati, Enrico Tongiorgi   +5 more
wiley   +1 more source

Hypericum empetrifolium and H. lydium as Health Promoting Nutraceuticals: Assessing Their Role Combining In Vitro In Silico and Chemical Approaches

Food Science &Nutrition, Volume 13, Issue 4, April 2025.
The Hypericum can be considered a good vegetal source for the preparation of nutraceuticals and food supplements useful as health‐promoting products against oxidative stress‐related diseases such as diabetes, cancer, and Alzheimer's disease. ABSTRACT Hypericum species are known for their ability to produce multiple classes of secondary metabolite and ...
Stefania Sut, Stefano Dall'Acqua, Giancarlo Angeles Flores, Gaia Cusumano, İsmail Koyuncu, Ozgur Yuksekdag, Carla Emiliani, Roberto Venanzoni, Paola Angelini, Selami Selvi, Evren Yildiztugay, Adriano Mollica, Eleonora Procino, Gregorio Peron, Lorenza Marinaccio, Gokhan Zengin   +15 more
wiley   +1 more source

Alzheimer Disease and Acetylcholinesterase Inhibitors [PDF]

, 2016
Alzheimer\u27s disease (AD) or Alzheimer\u27s is a is a chronic neurodegenerative disorder. It\u27s characterized by loss of neurons and synapses in the cerebral cortex and certain subcortical regions.
Kabouche, Z. (Zahia)
core   +2 more sources

Dissecting specialized metabolism in space: A MALDI-MSI atlas of Amaryllidaceae alkaloids in Hippeastrum papilio (Ravenna) Van Scheepen

Current Plant Biology
Amaryllidoideae produce specific specialized metabolites called Amaryllidaceae alkaloids (AAs), known for their pharmacological potential. The spatial distribution and biosynthesis within plant tissues, however, remain poorly understood.
Nuwan Sameera Liyanage, Natacha Mérindol, Sajjad Sobhanverdi, Kenneth Munk Pedersen, Christian Janfelt, Isabel Desgagné-Penix   +5 more
doaj   +1 more source

Alkaloids from Stems of Esenbeckia leiocarpa Engl. (Rutaceae) as Potential Treatment for Alzheimer Disease

Molecules, 2010
Esenbeckia leiocarpa Engl. (Rutaceae), popularly known as guarantã, goiabeira, is a native tree from Brazil. Bioactivity-guided fractionation of the ethanol stems extract afforded the isolation of six alkaloids: leiokinine A, leptomerine, kokusaginine ...
Elaine Monteiro Cardoso-Lopes, James Andreas Maier, Marcelo Rogério da Silva, Luis Octávio Regasini, Simone Yasue Simote, Norberto Peporine Lopes, Maria Cláudia Marx Young, José Rubens Pirani, Vanderlan da Silva Bolzani   +8 more
doaj   +1 more source

Cannabinoid CB1 receptor binding and acetylcholinesterase inhibitory activity of Sceletium tortuosum L. [PDF]

, 2010
The whole plant extract of plant Sceletium tortuosum, plant native to South Africa, has been known traditionally to have mood enhancing and stimulant properties. These properties have been confirmed before by proving serotonin-uptake inhibition activity.
Khatib, Alfi, Lubbe, Andrea, Nancy Dewi Yuliana,, Selamat, Jinap, Verpoorte, Robert   +4 more
core  

Alkaloid Profile, Anticholinesterase and Antioxidant Activities, and Sexual Propagation in Hieronymiella peruviana (Amaryllidaceae). [PDF]

Plants (Basel)
Hieronymiella peruviana, a recently described endemic species from southern Peru, belongs to the Amaryllidaceae family and is known for its diversity of alkaloids.
Llalla-Cordova O, Ortiz JE, Tallini LR, Torras-Claveria L, Bastida J, Luna LC, Feresin GE.   +6 more
europepmc   +2 more sources