Results 91 to 100 of about 20,091 (201)

Peptides binding cocaine: A strategy to design biomimetic receptors [PDF]

, 2013
A computational methodology for designing and rationalizing the selection of small peptides as biomimetic receptors for cocaine is proposed. The method started by searching and filtering proteins X-ray and NMR data of biological receptor-cocaine ...
Compagnone, Dario, Curini, Roberta, Del Carlo, Michele, Mascini, Marcello, Montero-Cabrera, Luis Alberto, Perez, German, Sergi, Manuel   +6 more
core   +1 more source

Hypericum empetrifolium and H. lydium as Health Promoting Nutraceuticals: Assessing Their Role Combining In Vitro In Silico and Chemical Approaches

Food Science &Nutrition, Volume 13, Issue 4, April 2025.
The Hypericum can be considered a good vegetal source for the preparation of nutraceuticals and food supplements useful as health‐promoting products against oxidative stress‐related diseases such as diabetes, cancer, and Alzheimer's disease. ABSTRACT Hypericum species are known for their ability to produce multiple classes of secondary metabolite and ...
Stefania Sut, Stefano Dall'Acqua, Giancarlo Angeles Flores, Gaia Cusumano, İsmail Koyuncu, Ozgur Yuksekdag, Carla Emiliani, Roberto Venanzoni, Paola Angelini, Selami Selvi, Evren Yildiztugay, Adriano Mollica, Eleonora Procino, Gregorio Peron, Lorenza Marinaccio, Gokhan Zengin   +15 more
wiley   +1 more source

Dissecting specialized metabolism in space: A MALDI-MSI atlas of Amaryllidaceae alkaloids in Hippeastrum papilio (Ravenna) Van Scheepen

Current Plant Biology
Amaryllidoideae produce specific specialized metabolites called Amaryllidaceae alkaloids (AAs), known for their pharmacological potential. The spatial distribution and biosynthesis within plant tissues, however, remain poorly understood.
Nuwan Sameera Liyanage, Natacha Mérindol, Sajjad Sobhanverdi, Kenneth Munk Pedersen, Christian Janfelt, Isabel Desgagné-Penix   +5 more
doaj   +1 more source

Alkaloids from Stems of Esenbeckia leiocarpa Engl. (Rutaceae) as Potential Treatment for Alzheimer Disease

Molecules, 2010
Esenbeckia leiocarpa Engl. (Rutaceae), popularly known as guarantã, goiabeira, is a native tree from Brazil. Bioactivity-guided fractionation of the ethanol stems extract afforded the isolation of six alkaloids: leiokinine A, leptomerine, kokusaginine ...
Elaine Monteiro Cardoso-Lopes, James Andreas Maier, Marcelo Rogério da Silva, Luis Octávio Regasini, Simone Yasue Simote, Norberto Peporine Lopes, Maria Cláudia Marx Young, José Rubens Pirani, Vanderlan da Silva Bolzani   +8 more
doaj   +1 more source

A Novel Class of Selective Acetylcholinesterase Inhibitors: Synthesis and Evaluation of (E)-2-(Benzo[d]thiazol-2-yl)-3-heteroarylacrylonitriles

Molecules, 2012
(E)-2-(benzo[d]thiazol-2-yl)-3-heteroarylacrylonitriles are described as a new class of selective inhibitors of acetylcholinesterase (AChE). The most potent compound in the series exhibited good AChE inhibitory activity (IC50 = 64 µM). Compound
Jorge Trilleras, Margarita Gutiérrez Cabrera, Jans H. Alzate-Morales, Jairo Quiroga, Julio Caballero, Luis Astudillo Saavedra, Pedro de la Torre   +6 more
doaj   +1 more source

Alzheimer Disease and Acetylcholinesterase Inhibitors [PDF]

, 2016
Alzheimer\u27s disease (AD) or Alzheimer\u27s is a is a chronic neurodegenerative disorder. It\u27s characterized by loss of neurons and synapses in the cerebral cortex and certain subcortical regions.
Kabouche, Z. (Zahia)
core   +2 more sources

Galanthamin als AChE-Inhibitor : Beiträge zum rationalen Wirkstoffdesign [PDF]

von Christian PilgerPaderborn, Univ.-GH, Diss ...
Pilger, Christian
core  

Representation and Treatment of Haemofilia in the general populaton in Macedonia [PDF]

, 2012
Introduction: Defects in blood coagulation can be congenital or acquired. Haemophilia belongs to the congenital (hereditary) coagulopathies.It is inherited recessively by a mutant gene located on the X-chromosome, therefore it affects only men. Women are
Velickova, Nevenka
core  

Acetylcholinesterase inhibition by somes promising Brazilian medicinal plants

Brazilian Journal of Biology
A microplate assay and a thin-layer chromatography (TLC) "in situ" assay based on the Ellman assay was used to screen for acetylcholinesterase inhibitors from ethyl acetate and methanol extracts of Brazilian medicinal plants of families that, according ...
CM. Feitosa, RM. Freitas, NNN. Luz, MZB. Bezerra, MTS. Trevisan   +4 more
doaj   +1 more source

Efficient synthesis of galanthamine

, 2013
The present invention relates to methods for the synthesis of galanthamine, morphine, intermediates, salts and derivatives thereof. In preferred embodiments, the invention relates to methods for improving the efficiency and overall yield of said morphine, morphine related derivatives and intermediates thereof.
Philip D. Magnus, Neeraj Sane, Ben Fauber   +2 more
openaire   +2 more sources