Results 41 to 50 of about 20,091 (201)

Molecular docking simulation studies on potent butyrylcholinesterase inhibitors obtained from microbial transformation of dihydrotestosterone [PDF]

, 2013
BACKGROUND: Biotransformation is an effective technique for the synthesis of libraries of bioactive compounds. Current study on microbial transformation of dihydrotestosterone (DHT) (1) was carried out to produce various functionalized metabolites ...
Kourosh Dalvandi, M Choudhary, Salman Zafar, Uzma Mahmood, Zaheer Ul-Haq   +4 more
core   +2 more sources

Alkaloids from Hippeastrum papilio

Molecules, 2011
Galanthamine, an acetylcholinesterase inhibitor marketed as a hydrobromide salt (Razadyne®, Reminyl®) for the treatment of Alzheimer’s disease (AD), is obtained from Amaryllidaceae plants, especially those belonging to the genera Leucojum, Narcissus ...
Jaume Bastida, Jean Paulo de Andrade, José Angelo S. Zuanazzi, Carles Codina, Francesc Viladomat, Strahil Berkov   +5 more
doaj   +1 more source

Elucidating the enzyme network driving Amaryllidaceae alkaloids biosynthesis in Leucojum aestivum. [PDF]

Plant Biotechnol J
Schematic representation of Amaryllidaceae alkaloid biosynthesis in Leucojum aestivum. Norbelladine synthase (LaNBS) and noroxomaritidine/norcraugsodine reductase (LaNRII) catalyze the condensation of tyramine and 3,4‐dihydroxybenzaldehyde to form norbelladine, which is subsequently O‐methylated by norbelladine‐4′‐O‐methyltransferase (LaN4′OMT ...
Lamichhane B, Gélinas SE, Merindol N, Koirala M, Dos Santos KCG, Germain H, Desgagné-Penix I.   +6 more
europepmc   +2 more sources

Identification of Alkaloids from Hippeastrum aulicum (Ker Gawl.) Herb.(Amaryllidaceae) Using CGC-MS and Ambient Ionization Mass Spectrometry (PS-MS and LS-MS) [PDF]

, 2017
Amaryllidaceae alkaloids are well-known isoquinolines which have demonstrated a wide range of biological activities such as antiviral, anticancer, acetylcholinesterase inhibition, antimalarial, among others.
Andrade, Jean Paulo de, Bastida Armengol, Jaume, Bessa, Carliani D.P.B., Borges, Warley S., Domingos, Eloilson, Oliveira, Renata S. de, Romão, Wanderson, Santos, Heloa   +7 more
core   +1 more source

Production and antioxidant capacity of tissue cultures from four Amaryllidaceae species [PDF]

, 2017
The aim of this study was (i) to produce tissue cultures capable of efficient plant regeneration from European naturally occurring protected and/or pharmacologically important Amaryllidaceae species and (ii) to test them for antioxidant activities in ...
Ajtay, Kitti, Freytag, Csongor, Gonda, Sándor, Kalydi, Fruzsina, Mikóné Hamvas, Márta, Máthé, Csaba, Papp, László, Resetár, Anna   +7 more
core   +3 more sources

Wild Argentinian Amaryllidaceae, a New Renewable Source of the Acetylcholinesterase Inhibitor Galanthamine and Other Alkaloids

Molecules, 2012
The Amaryllidaceae family is well known for its pharmacologically active alkaloids. An important approach to treat Alzheimer’s disease involves the inhibition of the enzyme acetylcholinesterase (AChE).
Gabriela E. Feresin, Jaume Bastida, Alejandro Tapia, German Roitman, Cristina Theoduloz, Strahil Berkov, Natalia B. Pigni, Javier E. Ortiz   +7 more
doaj   +1 more source

Carbohydrates stimulated Amaryllidaceae alkaloids biosynthesis in Leucojum aestivum L. plants cultured in RITA® bioreactor [PDF]

PeerJ, 2020
Background Leucojum aestivum L. is an important medicinal plant which produces Amaryllidaceae alkaloids, especially galanthamine and lycorine. Research is currently exploring the possibility of producing these alkaloids using biotechnological methods ...
Agata Ptak, Emilia Morańska, Edyta Skrzypek, Marzena Warchoł, Rosella Spina, Dominique Laurain-Mattar, Magdalena Simlat   +6 more
doaj   +2 more sources

Dynamics of Growth and Galanthamine Biosynthesis in Hippeastrum papilio (Ravena) Van Sheepen Hydroponic Culture

Agronomy
Hippeastrum papilio (Ravena) van Sheepen is a bulbous evergreen species and considered a potential new source of galanthamine. This natural compound approved by the FDA is used for the cognitive treatment of Alzheimer’s disease.
Gabriela Haist, Borjana Sidjimova, Rumen Denev, Jaume Bastida, Strahil Berkov   +4 more
doaj   +1 more source

Pharmacognosy: Science of natural products in drug discovery [PDF]

BioImpacts, 2014
Pharmacognosy deals with the natural drugs obtained fromorganisms such as most plants, microbes, and animals. Up todate, many important drugs including morphine, atropine,galanthamine, etc.
Ilkay Erdogan Orhan
doaj   +1 more source

Crinum jagus: antiproliferative studies of extracts on HepG2 cell line and in silico assessment of phytoconstituents as potential inhibitors of p53–mortalin interaction

Future Journal of Pharmaceutical Sciences, 2023
Background Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide and has a poor prognosis in black Africans. Traditional herbal practitioners in southwestern Nigeria use Crinum jagus (J. Thompson) Dandy for cancer treatment.
Taye Temitope Alawode, Labunmi Lajide, Mary Olaleye, Bodunde Owolabi   +3 more
doaj   +1 more source