Molecular docking simulation studies on potent butyrylcholinesterase inhibitors obtained from microbial transformation of dihydrotestosterone [PDF]
, 2013 BACKGROUND: Biotransformation is an effective technique for the synthesis of libraries of bioactive compounds. Current study on microbial transformation of dihydrotestosterone (DHT) (1) was carried out to produce various functionalized metabolites ...
Kourosh Dalvandi +4 more
core +2 more sources
Elucidating the enzyme network driving Amaryllidaceae alkaloids biosynthesis in Leucojum aestivum. [PDF]
Plant Biotechnol JSchematic representation of Amaryllidaceae alkaloid biosynthesis in Leucojum aestivum. Norbelladine synthase (LaNBS) and noroxomaritidine/norcraugsodine reductase (LaNRII) catalyze the condensation of tyramine and 3,4‐dihydroxybenzaldehyde to form norbelladine, which is subsequently O‐methylated by norbelladine‐4′‐O‐methyltransferase (LaN4′OMT ...
Lamichhane B +6 more
europepmc +2 more sources
Frontiers in Plant Science, 2020 Lycoris longituba is a traditional medicinal plant containing the bioactive compound galanthamine (Gal), a type of Amaryllidaceae alkaloid and can be used to treat Alzheimer’s disease. However, research on its genome or transcriptome and associated genes
Qingzhu Li +5 more
doaj +1 more source
Acetylcholineestarase-inhibiting alkaloids from Lycoris radiata delay paralysis of amyloid beta-expressing transgenic C. elegans CL4176. [PDF]
PLoS ONE, 2013 The limited symptom relief and side effects of current Alzheimer's disease (AD) medications warrant urgent discovery and study of new anti-AD agents. The "cholinergic hypothesis" of AD prompts us to search for plant-derived acetylcholineesterase (AChE ...
Lijuan Xin +7 more
doaj +1 more source
Alkaloids from Hippeastrum papilio
Molecules, 2011 Galanthamine, an acetylcholinesterase inhibitor marketed as a hydrobromide salt (Razadyne®, Reminyl®) for the treatment of Alzheimer’s disease (AD), is obtained from Amaryllidaceae plants, especially those belonging to the genera Leucojum, Narcissus ...
Jaume Bastida +5 more
doaj +1 more source
Identification of Alkaloids from Hippeastrum aulicum (Ker Gawl.) Herb.(Amaryllidaceae) Using CGC-MS and Ambient Ionization Mass Spectrometry (PS-MS and LS-MS) [PDF]
, 2017 Amaryllidaceae alkaloids are well-known isoquinolines which have demonstrated a wide range of biological activities such as antiviral, anticancer, acetylcholinesterase inhibition, antimalarial, among others.
Andrade, Jean Paulo de +7 more
core +1 more source
Histochemical Localization and Cytotoxic Potential of Alkaloids in Phaedranassa lehmannii. [PDF]
Plants (Basel)Plants of the subfamily Amaryllidoideae are a source of unique and bioactive alkaloids called Amaryllidaceae alkaloids. The study of their anticancer potential has intensified in recent years.
Trujillo Chacón LM +6 more
europepmc +2 more sources
Production and antioxidant capacity of tissue cultures from four Amaryllidaceae species [PDF]
, 2017 The aim of this study was (i) to produce tissue cultures capable of efficient plant regeneration from European naturally occurring protected and/or pharmacologically important Amaryllidaceae species and (ii) to test them for antioxidant activities in ...
Ajtay, Kitti +7 more
core +3 more sources
Molecules, 2012 The Amaryllidaceae family is well known for its pharmacologically active alkaloids. An important approach to treat Alzheimer’s disease involves the inhibition of the enzyme acetylcholinesterase (AChE).
Gabriela E. Feresin +7 more
doaj +1 more source
Carbohydrates stimulated Amaryllidaceae alkaloids biosynthesis in Leucojum aestivum L. plants cultured in RITA® bioreactor [PDF]
PeerJ, 2020 Background Leucojum aestivum L. is an important medicinal plant which produces Amaryllidaceae alkaloids, especially galanthamine and lycorine. Research is currently exploring the possibility of producing these alkaloids using biotechnological methods ...
Agata Ptak +6 more
doaj +2 more sources