Results 1 to 10 of about 4,219,302 (284)
Galectin-9 in Gastroenterological Cancer. [PDF]
Int J Mol Sci, 2023 Immunochemotherapy has become popular in recent years. The detailed mechanisms of cancer immunity are being elucidated, and new developments are expected in the future.
Morishita A +7 more
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T lymphocytes induce human cancer cells derived from solid malignant tumors to secrete galectin-9 which facilitates immunosuppression in cooperation with other immune checkpoint proteins [PDF]
Journal for ImmunoTherapy of Cancer, 2023 Background Galectin-9 is a member of the family of lectin proteins and crucially regulates human immune responses, particularly because of its ability to suppress the anticancer activities of T lymphocytes and natural killer cells.
Stephanie Schlichtner +9 more
doaj +5 more sources
Serum Galectin‐1, Galectin‐9, and YKL‐40 levels in bipolar disorder and their relationship with cognitive functions [PDF]
Brain and BehaviorPurpose The number of studies conducted on the role of neuroinflammation in the etiopathogenesis of bipolar disorder has been increasing in recent years.
Elcicek Selahaddin +6 more
doaj +3 more sources
"Galectin-9: A double-edged sword in Acute Myeloid Leukemia". [PDF]
Ann HematolAcute Myeloid Leukemia (AML) presents a formidable challenge in the realm of hematologic malignancies, characterized by the unregulated proliferation of myeloid progenitor cells, leading to severe disruptions in normal hematopoiesis. This review examines
Aval OS +7 more
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Hematology, 2023 The interaction between Tim-3 on T cells and its ligand Galectin-9 negatively regulates the cellular immune response. However, the regulation of Tim-3/Galectin-9 on CD4 T cell subsets in multiple myeloma (MM) remains unclear. The aim of this study was to
Rui Zhang +4 more
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Nature Communications, 2021 Galectin-9 regulates several cellular processes including TIM-3-mediated T cell death. Here the authors show that co-expressed PD-1 protects TIM-3+ T cells from galectin-9-induced cell death and that anti-galectin-9 in combination with GITR agonism ...
Riyao Yang +16 more
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The regulating role of galectin-9 in immune cell populations. [PDF]
Front PharmacolGalectin-9 (gal-9) is a protein that belongs to the galectin family. Gal-9 is expressed in cells of the innate and adaptive immune system, including lymphocytes, dendritic cells, giant salivary cells, eosinophils and T cells, etc.
Cao Z, Leng P, Xu H, Li X.
europepmc +2 more sources
Advanced ScienceTumor‐initiating cells (TICs) resilience and an immunosuppressive microenvironment are aggressive oncogenic phenotypes that contribute to unsatisfactory long‐term outcomes in lung adenocarcinoma (LUAD) patients.
Zhi‐Jie Xiao +10 more
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Biomolecules, 2023 Gestational diabetes mellitus (GDM) is a common metabolic disease that occurs during pregnancy, with the placenta playing an important role in its pathophysiology. Currently, the role of galectin-9 in the development of GDM is unknown.
Aleksandra Pełech +7 more
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Galectin-9 - ligand axis: an emerging therapeutic target for multiple myeloma. [PDF]
Front ImmunolGalectin-9 (Gal-9) is a tandem-repeat galectin with diverse roles in immune homeostasis, inflammation, malignancy, and autoimmune diseases. In cancer, Gal-9 displays variable expression patterns across different tumor types.
Shil RK, Mohammed NBB, Dimitroff CJ.
europepmc +2 more sources