Results 11 to 20 of about 4,219,302 (284)

A new emerging target in cancer immunotherapy: Galectin-9 (LGALS9)

Genes and Diseases, 2023
Over the past few decades, advances in immunological knowledge have led to the identification of novel immune checkpoints, reinvigorating cancer immunotherapy.
Yan Lv, Xiao Ma, Yuxin Ma, Yuxin Du, Jifeng Feng   +4 more
doaj   +2 more sources

Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation. [PDF]

PLoS Pathogens, 2016
Identifying host immune determinants governing HIV transcription, latency and infectivity in vivo is critical to developing an HIV cure. Based on our recent finding that the host factor p21 regulates HIV transcription during antiretroviral therapy (ART),
Mohamed Abdel-Mohsen, Leonard Chavez, Ravi Tandon, Glen M Chew, Xutao Deng, Ali Danesh, Sheila Keating, Marion Lanteri, Michael L Samuels, Rebecca Hoh, Jonah B Sacha, Philip J Norris, Toshiro Niki, Cecilia M Shikuma, Mitsuomi Hirashima, Steven G Deeks, Lishomwa C Ndhlovu, Satish K Pillai   +17 more
doaj   +5 more sources

Galectin‐9 alleviates acute graft‐versus‐host disease after haplo‐hematopoietic stem cell transplantation by regulating regulatory T cell/effector T cell imbalance

Immunity, Inflammation and Disease
Background Acute graft‐versus‐host disease (aGVHD) arises from the imbalance of host T cells. Galectin‐9 negatively regulates CD4 effector T cell (Th1 and Th17) function by binding to Tim‐3.
Nannan Pang, Shabaaiti Tudahong, Yuejie Zhu, Jiang He, Chunxia Han, Gang Chen, Weiguo Wang, Jing Wang, Jianbing Ding   +8 more
doaj   +2 more sources

Peripheral blood TIM-3 positive NK and CD8+ T cells throughout pregnancy: TIM-3/galectin-9 interaction and its possible role during pregnancy. [PDF]

PLoS ONE, 2014
The T-cell immunoglobulin and mucin domain (TIM) family is a relatively newly described group of molecules with a conserved structure and important immunological functions. Identification of Galectin-9 as a ligand for TIM-3 has established the Galectin-9/
Matyas Meggyes, Eva Miko, Beata Polgar, Barbara Bogar, Balint Farkas, Zsolt Illes, Laszlo Szereday   +6 more
doaj   +3 more sources

PRDX2 induces tumor immune evasion by modulating the HDAC3-Galectin-9 axis in lung adenocarcinoma cells. [PDF]

J Transl Med
PRDX2 is significantly expressed in various cancers and is associated with the proliferation of tumor cells. Nonetheless, the precise mechanism of PRDX2 in tumor immunity remains incompletely understood. This study aims to investigate the impact of PRDX2,
Dong Y, Cheng A, Zhou J, Guo J, Liu Y, Li X, Chen M, Hu D, Wu J.   +8 more
europepmc   +2 more sources

Microglia-derived Galectin-9 drives amyloid-β pathology in Alzheimer's disease. [PDF]

Aging Cell
The accumulation of amyloid‐β (Aβ) and overactivation of microglia contribute to the pathogenesis of Alzheimer's disease (AD), but the interaction between microglial activation and Aβ deposition in AD remains elusive.
Zhang G, Peng Q, Guo X, Pan L, Xiong M, Zhang X, Dai L, Zhang Z, Xiao T, He J, Liu M, Ke W, Zhang Z.   +12 more
europepmc   +2 more sources

Plasma Galectin-9 Concentrations in Normal and Diseased Condition [PDF]

Cellular Physiology and Biochemistry, 2018
Background/Aims: Galectin-9 is a soluble immune modulator with versatile functions, including a role as an immune checkpoint molecule. Therefore, the amount of galectin-9 in the blood may reflect an individual’s immunological balance.
Toshiro Niki, Koji Fujita, Hugo Rosen, Mitsuomi Hirashima, Tsutomu Masaki, Toshio Hattori, Katsuaki Hoshino   +6 more
doaj   +3 more sources

Galectin-9: A Suppressor of Atherosclerosis? [PDF]

Frontiers in Immunology, 2020
It is no longer controversial that atherosclerosis is a vascular wall chronic inflammatory disease mediated by cells of innate and adaptive immunity. Galectin-9 (Gal-9) seems to be a crucial regulator of T-cell immunity by inducing apoptosis in specific ...
Jian Yu, Ruirui Zhu, Kunwu Yu, Yue Wang, Yan Ding, Yucheng Zhong, Qiutang Zeng   +6 more
doaj   +3 more sources

Galectin‐9 and myeloid‐derived suppressor cell as prognostic indicators for chronic lymphocytic leukemia

Immunity, Inflammation and Disease, 2023
Background Galectin‐9 and myeloid‐derived suppressor cells (MDSCs) have an important role in tumors, but their clinical values in chronic lymphocytic leukemia (CLL) have not been fully elucidated.
Xierenguli Alimu, Juan Zhang, Nannan Pang, Rui Zhang, Rong Chen, Xuejiao Zeng, Shabaaiti Tudahong, Gang Chen, Maliya Muhashi, Fang Zhao, Jianbing Ding, Jianhua Qu   +11 more
doaj   +2 more sources

Autophagy-independent role of ATG9A vesicles as carriers for galectin-9 secretion [PDF]

Nature Communications
Galectins play vital roles in cellular processes such as adhesion, communication, and survival, yet the mechanisms underlying their unconventional secretion remain poorly understood.
Wenting Zhang, Cuicui Ji, Xianghua Li, Tianlong He, Wei Jiang, Yukun Liu, Meiling Wu, Yunpeng Zhao, Xuechai Chen, Xiaoli Wang, Jian Li, Haolin Zhang, Juan Wang   +12 more
doaj   +2 more sources