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ATXN3 functions as a tumor suppressor through potentiating galectin-9-mediated apoptosis in human colon adenocarcinoma. [PDF]
J Biol ChemCheng Y, Wang S, Gao Q, Fang D.
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Galectin-9 as a biomarker of disease severity.
Cellular Immunology, 2021Galectin-9 (Gal-9) is a β-galactoside binding lectin known for its immunomodulatory role in various microbial infections. Gal-9 is expressed in all organ systems and localized in the nucleus, cell surface, cytoplasm and the extracellular matrix.
P. Moar, R. Tandon
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Immunotherapy, 2023
Background: The study aimed to evaluate the effect of a galectin-9 and PD-L1 combined blockade in pancreatic ductal adenocarcinoma (PDAC). Methods: The expression of galectin-9 and PD-L1 was analyzed in PDAC.
Enliang Li +5 more
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Background: The study aimed to evaluate the effect of a galectin-9 and PD-L1 combined blockade in pancreatic ductal adenocarcinoma (PDAC). Methods: The expression of galectin-9 and PD-L1 was analyzed in PDAC.
Enliang Li +5 more
semanticscholar +1 more source
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery, 2013
Galectin-9 is a tandem-repeat type galectin with two carbohydrate-recognition domains, and it was first identified as an eosinophil chemoattractant and activation factor. Subsequent studies revealed that galectin-9, similar to other galectins, modulates a variety of biological functions including cell aggregation and adhesion, as well as apoptosis of ...
Shintaro, Fujihara +6 more
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Galectin-9 is a tandem-repeat type galectin with two carbohydrate-recognition domains, and it was first identified as an eosinophil chemoattractant and activation factor. Subsequent studies revealed that galectin-9, similar to other galectins, modulates a variety of biological functions including cell aggregation and adhesion, as well as apoptosis of ...
Shintaro, Fujihara +6 more
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Galectin-9 is a target for the treatment of cancer: A patent review.
International Journal of Biological Macromolecules, 2023Galectins, which correspond to a group of proteins capable of recognizing and reversibly binding to β-galactoside carbohydrates, have been the subject of innovation and development of technological products.
Cássia Ferreira Rodrigues +5 more
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Identification of Galectin 9 and its antibacterial function in yellow drum (Nibea albiflora).
Fish and Shellfish Immunology, 2023Galectins are a family of evolutionarily conserved lectins that contain carbohydrate recognition domains (CRDs) specifically recognizing β-galactoside. Galectin-9 plays a crucial role in various biological processes during pathogenic infections.
Shuai Luo +6 more
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Association of Galectin-9 with Eosinophil Apoptosis
International Archives of Allergy and Immunology, 2002<i>Background:</i> There is no information whether galectin-9 (a novel eosinophil chemoattractant) was associated with pathogenesis of eosinophilic disorders. <i>Methods: </i>We assessed the expression of galectin-9 with imunostaining and in situ hybridization both in the lesion of angiolymphoid hyperplasia with eosinophilia ...
Naoki, Saita +11 more
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Galectin-9 in physiological and pathological conditions
Glycoconjugate Journal, 2002We first cloned galectin-9 (Gal-9)/ecalectin as a T cell-derived eosinophil chemoattractant. Gal-9 plays a role in not only accumulation but also activation of eosinophils in experimental allergic models and human allergic patients, because Gal-9 induces eosinophil chemoattraction in vitro and in vivo and activates eosinophils in many aspects.
Mitsuomi, Hirashima +7 more
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Serum level of galectin-9 as a potential biomarker for high risk of malignancy in dermatomyositis.
Rheumatology, 2023OBJECTIVES Galectin-9, as immune checkpoint protein, plays a role in regulating autoimmunity and tumour immunity. Therefore, we explored the pathophysiological link between galectin-9 and malignancy in cancer-related DM (CRDM). METHODS Serum galectin-9
Yanting Shih +15 more
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Expression of Galectin-9-related immune checkpoint receptors in B-cell acute lymphoblastic leukemia
Iranian Journal of Basic Medical Sciences, 2023Objective(s): Exhausted CD8+ T-cells over-express immune checkpoint receptors (ICRs), which interact with their ligands on malignant cells. However, some ICRs have been reported to be expressed on both T-cells and tumor cells, including V-domain ...
Armin Akbar +10 more
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