Autophagy-independent role of ATG9A vesicles as carriers for galectin-9 secretion [PDF]
Nature CommunicationsGalectins play vital roles in cellular processes such as adhesion, communication, and survival, yet the mechanisms underlying their unconventional secretion remain poorly understood.
Wenting Zhang +12 more
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Galectin-9 binds IgM-BCR to regulate B cell signaling [PDF]
Nature Communications, 2018 The galectin family of secreted lectins are important regulators of immune cell function; however, their role in B cell responses is poorly understood. Here, the authors identify IgM-BCR as a ligand for galectin-9.
Anh Cao +11 more
doaj +5 more sources
Alarmin function of galectin-9 in murine respiratory tularemia.
PLoS ONE, 2015 Sepsis is a complex immune disorder that is characterized by systemic hyperinflammation. Alarmins, which are multifunctional endogenous factors, have been implicated in exacerbation of inflammation in many immune disorders including sepsis.
Anthony L Steichen +5 more
doaj +4 more sources
Galectin-9 Triggers Neutrophil-Mediated Anticancer Immunity [PDF]
Biomedicines, 2021 In earlier studies, galectin-9 (Gal-9) was identified as a multifaceted player in both adaptive and innate immunity. Further, Gal-9 had direct cytotoxic and tumor-selective activity towards cancer cell lines of various origins. In the current study, we identified that treatment with Gal-9 triggered pronounced membrane alterations in cancer cells ...
Natasha Ustyanovska Avtenyuk +8 more
openaire +4 more sources
Tim-3/galectin-9 regulates Th1/Th2 cell balance in lipopolysaccharide-induced human lymphocytes [PDF]
Jichu yixue yu linchuang, 2023 Objective To investigate the mechanism of Tim-3/galectin-9 in T helper type 1/2 (Th1/Th2) cell imbalance in lipopolysaccharide(LPS)-induced human lymphocytes.
SUN Xiaoli, ZHANG Jinjin, SONG Fengying, HUANG Yongli, CHEN Lili, XING Yanchao
doaj +1 more source
BMC Cancer, 2022 Background Galectin-9 is a member of the galectin family and has been reported to have a tumor-promoting or antitumor effect in response to the immune microenvironment. However, the immunomodulatory effect of galectin-9 in colorectal cancer (CRC) remains
Yang Wang +6 more
doaj +1 more source
Galectin-9: diverse roles in skin disease. [PDF]
Front AllergyGalectin-9 (Gal-9) is a multifunctional immunomodulatory molecule involved in cell growth, differentiation, adhesion, communication, and death. Galectin-9 mediates its physiological functions through interactions with multiple membrane receptors, including T-cell immunoglobulin mucin-domain containing-3 (Tim-3), immunoglobulin E, and the hyaluronan ...
Wang L, Zhang C, Ji J, Jiao Q.
europepmc +3 more sources
Reduced Expression of Galectin-9 Contributes to a Poor Outcome in Colon Cancer by Inhibiting NK Cell Chemotaxis Partially through the Rho/ROCK1 Signaling Pathway. [PDF]
PLoS ONE, 2016 Galectin-9 is a widely expressed protein that is involved in immune regulation and tumorpathogenesis and serves as a marker of a poor prognosis in various types of cancers.
Yang Wang +17 more
doaj +1 more source
Galectin Family Members: Emerging Novel Targets for Lymphoma Therapy?
Frontiers in Oncology, 2022 The galectin family of proteins has high affinity with β-galactoside-containing glycans. These proteins participate in cell growth and differentiation, cell adhesion, cell signal transduction, cell apoptosis, and other cellular activities.
Yuanwei Shi +10 more
doaj +1 more source
Galectin-9 ameliorates clinical severity of MRL/lpr lupus-prone mice by inducing plasma cell apoptosis independently of Tim-3. [PDF]
PLoS ONE, 2013 Galectin-9 ameliorates various murine autoimmune disease models by regulating T cells and macrophages, although it is not known what role it may have in B cells.
Masahiro Moritoki +9 more
doaj +1 more source