Results 31 to 40 of about 4,219,302 (284)
Galectin-9 ameliorates clinical severity of MRL/lpr lupus-prone mice by inducing plasma cell apoptosis independently of Tim-3. [PDF]
PLoS ONE, 2013 Galectin-9 ameliorates various murine autoimmune disease models by regulating T cells and macrophages, although it is not known what role it may have in B cells.
Masahiro Moritoki +9 more
doaj +1 more source
Astrocyte galectin-9 potentiates microglial TNF secretion [PDF]
Journal of Neuroinflammation, 2014 Aberrant neuroinflammation is suspected to contribute to the pathogenesis of myriad neurological diseases. As such, determining the pathways that promote or inhibit glial activation is of interest. Activation of the surface glycoprotein T-cell immunoglobulin and mucin-domain containing protein 3 (Tim-3) by the lectin galectin-9 has been implicated in ...
Steelman, Andrew J, Li, Jianrong
openaire +2 more sources
Journal of Biomedical Science, 2020 Background Galectin-9 is a β-galactoside-binding protein with two carbohydrate recognition domains. Recent studies have revealed that galectin-9 regulates cellular biological reactions and plays a pivotal role in fibrosis.
Yu-An Hsu +7 more
doaj +1 more source
Cancer Therapy Due to Apoptosis: Galectin-9 [PDF]
International Journal of Molecular Sciences, 2017 Dysregulation of apoptosis is a major hallmark in cancer biology that might equip tumors with a higher malignant potential and chemoresistance. The anti-cancer activities of lectin, defined as a carbohydrate-binding protein that is not an enzyme or antibody, have been investigated for over a century.
Koji Fujita +12 more
openaire +2 more sources
Galectin-9 promotes natural killer cells activity via interaction with CD44
Frontiers in Immunology, 2023 Natural killer (NK) cells are a potent innate source of cytokines and cytoplasmic granules. Their effector functions are tightly synchronized by the balance between the stimulatory and inhibitory receptors.
Amirhossein Rahmati +2 more
semanticscholar +1 more source
Galectin‐9: a suppressor of food allergy? [PDF]
Allergy, 2012 The prevalence of food-induced allergy, which affects approximately 5% of children and 3–4% of adults, is on the rise. It is manifested in a variety of symptoms and disorders involving the gastrointestinal and respiratory tracts as well as skin (1). The pathogenesis of allergic diseases, such as allergic asthma, allergic dermatitis or food allergy is ...
Erna, Sziksz +2 more
openaire +2 more sources
Vaccines, 2021 During a specific milk fermentation process with Bifidobacterium breve C50 and Streptococcus thermophilus 065 (LactofidusTM), postbiotics with possible immunomodulatory properties are produced. We investigated the effects of this fermentation product (FP)
Veronica Ayechu-Muruzabal +9 more
doaj +1 more source
Galectin-9 blockade synergizes with ATM inhibition to induce potent anti-tumor immunity
International Journal on Biological Sciences, 2023 Although current cancer immunotherapies that target PD-1/PD-L1 immune checkpoint to reinvigorate exhausted T cells have achieved impressive clinical outcomes, only a small proportion of patients respond. New therapeutic targets are therefore needed to be
S. Zheng +10 more
semanticscholar +1 more source
Galectin-1, -3 and -9 Expression and Clinical Significance in Squamous Cervical Cancer. [PDF]
PLoS ONE, 2015 Galectins are proteins that bind β-galactoside sugars and provide a new type of potential biomarkers and therapeutic targets in cancer. Galectin-1, -3 and -9 have become the focus of different research groups, but their expression and function in ...
Simone Punt +5 more
doaj +1 more source
Galectin-9 interacts with Vamp-3 to regulate cytokine secretion in dendritic cells
bioRxiv, 2023 Intracellular vesicle transport is essential for cellular homeostasis and is partially mediated by SNARE proteins. Endosomal trafficking to the plasma membrane ensures cytokine secretion in dendritic cells (DCs) and the initiation of immune responses ...
Rui Santalla Méndez +10 more
semanticscholar +1 more source