Results 41 to 50 of about 4,689,501 (274)

The immune receptor Tim-3 acts as a trafficker in a Tim-3/galectin-9 autocrine loop in human myeloid leukemia cells [PDF]

, 2016
The immune receptor Tim-3 is often highly expressed in human acute myeloid leukemia (AML) cells where it acts as a growth factor and inflammatory receptor.
Bardelli, Marco, Berger, Steffen M., Fasler-Kan, Elizaveta, Fruehwirth, Alexander, Gibbs, Bernhard F., Gonçalves Silva, Isabel, Rüegg, Laura, Sumbayev, Vadim V., Varani, Luca   +8 more
core   +1 more source

Human T cell glycosylation and implications on immune therapy for cancer [PDF]

, 2020
Glycosylation is an important post-translational modification, giving rise to a diverse and abundant repertoire of glycans on the cell surface, collectively known as the glycome.
Callewaert, Nico, De Bousser, Elien, Festjens, Nele, Meuris, Leander   +3 more
core   +1 more source

Galectin-9: A novel promoter of atherosclerosis progression

Atherosclerosis, 2022
Atherosclerosis is widely accepted to be an inflammatory disease driven by lipid accumulation and leukocyte recruitment. More recently, galectins, a family of β-galactoside binding proteins, have been shown to play a role in leukocyte recruitment among other immunomodulatory functions.
Krautter F., Hussain M. T., Zhi Z., Lezama D. R., Manning J. E., Brown E., Marigliano N., Raucci F., Recio C., Chimen M., Maione F., Tiwari A., McGettrick H. M., Cooper D., Fisher E. A., Iqbal A. J.   +15 more
openaire   +5 more sources

Galectin-9 regulates HTR8/SVneo function via JNK signaling [PDF]

Reproduction, 2021
To obtain a successful pregnancy, trophoblasts must provide a physical barrier, suppress maternal reactivity, produce immunosuppressive hormones locally, and enhance the production of blocking factors that are able to bind to several antigenic sites. Inadequate placental perfusion has been closely associated with several pregnancy-associated diseases ...
Mengdie Li, Xiandong Peng, Jinfeng Qian, Fengrun Sun, Chunqin Chen, Songcun Wang, Jianping Zhang, Meirong Du   +7 more
openaire   +2 more sources

Role of Galectins in the Liver Diseases: A Systematic Review and Meta-Analysis

Frontiers in Medicine, 2021
Background: Galectins, a family of β-galactoside-binding proteins, are related to the development and progression of various human diseases such as cancer, heart failure, and chronic kidney disease. However, its role in liver diseases is unclear.Methods:
Yang An, Yang An, Shixue Xu, Yiting Liu, Yiting Liu, Xiangbo Xu, Xiangbo Xu, Cyriac Abby Philips, Jiang Chen, Nahum Méndez-Sánchez, Xiaozhong Guo, Xingshun Qi   +11 more
doaj   +1 more source

PD-L1, Galectin-9 and CD8+ tumor-infiltrating lymphocytes are associated with survival in hepatocellular carcinoma [PDF]

, 2017
Novel systemic treatments for hepatocellular carcinoma (HCC) are strongly needed. Immunotherapy is a promising strategy that can induce specific antitumor immune responses.
Beuers, U. (Ulrich), Biermann, K. (Katharina), Boor, P.P.C. (Patrick), Bruno, M.J. (Marco), Buschow, S.I. (Sonja I.), Gulik, T.M. (Thomas) van, Hansen, B.E. (Bettina), IJzermans, J.N.M. (Jan), Kwekkeboom, J. (Jaap), Man, R.A. (Robert) de, Mancham, S. (Shanta), Pan, Q. (Qiuwei), Schutz, H.M. (Hannah M.), Sideras, K. (Kostandinos), Sleijfer, S. (Stefan), Sprengers, D. (Dave), Takkenberg, B.R. (Bart R.), Terkivatan, T. (Türkan), Verheij, J. (Joanne), Verseput, M.C.M. (Maddy C. M.)   +19 more
core   +1 more source

Galectin-9 interacts with Vamp-3 to regulate cytokine secretion in dendritic cells

bioRxiv, 2023
Intracellular vesicle transport is essential for cellular homeostasis and is partially mediated by SNARE proteins. Endosomal trafficking to the plasma membrane ensures cytokine secretion in dendritic cells (DCs) and the initiation of immune responses ...
Rui Santalla Méndez, Andrea Rodgers Furones, René Classens, Manon Haverdil, Marta Canela Capdevila, A. van Duffelen, C. G. Spruijt, M. Vermeulen, M. Ter Beest, A. V. van Spriel, L. Q. Cano   +10 more
semanticscholar   +1 more source

EZH2 promotes hepatocellular carcinoma progression through modulating miR-22/galectin-9 axis

Journal of Experimental & Clinical Cancer Research, 2018
Background Recent studies have shown that interferon-γ (IFN-γ)-induced galectin-9 expression in Kupffer cells plays an essential role in modulatingthe microenvironment of hepatitis-associated hepatocellular carcinoma (HCC).
Shaofei Chen, Jiarui Pu, Jie Bai, Yuping Yin, Ke Wu, Jiliang Wang, Xiaoming Shuai, Jinbo Gao, Kaixiong Tao, Guobin Wang, Hang Li   +10 more
doaj   +1 more source

Galectin-14 Promotes Trophoblast Migration and Invasion by Upregulating the Expression of MMP-9 and N-Cadherin

Frontiers in Cell and Developmental Biology, 2021
Galectin-14 is specifically expressed in placental trophoblasts, and its expression is reduced in trophoblasts retrieved from the cervix of women destined to develop early pregnancy loss.
Miaomiao Wang, Yuqing Xu, Peng Wang, Yanfei Xu, Pengzhen Jin, Zaigui Wu, Yeqing Qian, Yeqing Qian, Yeqing Qian, Long Bai, Long Bai, Minyue Dong, Minyue Dong, Minyue Dong   +13 more
doaj   +1 more source

Differential expression and biochemical activity of the immune receptor Tim-3 in healthy and malignant human myeloid cells [PDF]

, 2015
The T cell immunoglobulin and mucin domain 3 (Tim-3) is a plasma membrane-associated receptor which is involved in a variety of biological responses in human immune cells.
Bardelli, Marco, Gibbs, Bernhard F, Goncalves Silva, Isabel, Sumbayev, Vadim V., Varani, Luca   +4 more
core   +2 more sources