Results 51 to 60 of about 4,689,501 (274)

Galectin-9 influences the Tim-3 molecule expression in natural killer different subpopulations

Медицинская иммунология, 2023
Galectin-9 is a b-galactoside binding lectin with expressed immunoregulatory activity. During pregnancy galectin-9 is produced by trophoblast cells and regulates the function of natural killer (NK) cells at the maternal-fetal interface via binding to Tim-
E. G. Orlova, O. A. Loginova, O. L. Gorbunova, S. V. Shirshev   +3 more
doaj   +1 more source

Tumor-induced senescent T cells promote the secretion of pro-inflammatory cytokines and angiogenic factors by human monocytes/macrophages through a mechanism that involves Tim-3 and CD40L [PDF]

, 2014
Solid tumors are infiltrated by immune cells where macrophages and senescent T cells are highly represented. Within the tumor microenvironment, a cross-talk between the infiltrating cells may occur conditioning the characteristic of the in situ immune ...
Acosta Rodriguez, Eva Virginia, Canale, Fernando Pablo, Gastman, B, Gruppi, Adriana, Mena, Hebe Agustina, Montes, Carolina Lucia, Negrotto, Soledad, Ramello, María Cecilia, Tosello Boari, Jimena   +8 more
core   +2 more sources

NAFLD‐related hepatocellular carcinoma: The growing challenge

Hepatology, EarlyView., 2022
Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah, Rashmee Patil, Stephen A. Harrison   +2 more
wiley   +1 more source

Intracellular Galectin-9 Controls Dendritic Cell Function by Maintaining Plasma Membrane Rigidity

iScience, 2019
Summary: Endogenous extracellular Galectins constitute a novel mechanism of membrane protein organization at the cell surface. Although Galectins are also highly expressed intracellularly, their cytosolic functions are poorly understood.
Laia Querol Cano, Oya Tagit, Yusuf Dolen, Anne van Duffelen, Shannon Dieltjes, Sonja I. Buschow, Toshiro Niki, Mitsuomi Hirashima, Ben Joosten, Koen van den Dries, Alessandra Cambi, Carl G. Figdor, Annemiek B. van Spriel   +12 more
doaj   +1 more source

Galectin genes: regulation of expression. [PDF]

, 2002
In this review we have summarized the more recent studies on the expression of mammalian galectins. One interesting observation that can be made is that in most of microarrays and/or differential display analysis performed in recent years one or more ...
BRUNI, CARMELO BRUNO, CHIARIOTTI, LORENZO, FRUNZIO, RODOLFO, SALVATORE, PAOLA   +3 more
core   +1 more source

Increased tumor-associated mast cells facilitate thyroid cancer progression by inhibiting CD8+ T cell function through galectin-9

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2023
As an important component of solid tumors, mast cells show specific phenotypes in various tumor microenvironments. However, the precise mechanism of mast cell accumulation and the phenotypic features of thyroid cancer (TC) remain largely unknown.
Yanli Hou, Qiang Wang, Liuliu Su, Ying Zhu, Yun Xiao, Fei Feng   +5 more
semanticscholar   +1 more source

Galectin-9 ameliorates fulminant liver injury

Molecular Medicine Reports, 2017
Fulminant hepatitis is a severe liver disease resulting in hepatocyte necrosis. Galectin‑9 (Gal‑9) is a tandem‑repeat‑type galectin that has been evaluated as a potential therapeutic agent for various diseases that regulate the host immune system. Concanavalin A (ConA) injection into mice results in serious, immune‑mediated liver injury similar to ...
Tadokoro, Tomoko, Morishita, Asahiro, Sakamoto, Teppei, Fujihara, Shintaro, Fujita, Koji, Mimura, Shima, Oura, Kyoko, Nomura, Takako, Tani, Joji, Yoneyama, Hirohito, Iwama, Hisakazu, Himoto, Takashi, Niki, Toshiro, Hirashima, Mitsuomi, Masaki, Tsutomu   +14 more
openaire   +3 more sources

Different angioregulatory activity of monovalent galectin-9 isoforms [PDF]

Angiogenesis, 2018
Galectin-9 consists of two peptide-linked carbohydrate recognition domains (CRDs), but alternative splicing and proteolytic processing can give rise to multiple galectin-9 isoforms. Some of these consist of a single CRD and can exert different functions in cell biology.
Ed Aanhane, Iris A. Schulkens, Roy Heusschen, Kitty Castricum, Hakon Leffler, Arjan W. Griffioen, Victor L. Thijssen   +6 more
openaire   +4 more sources

IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH

Hepatology, EarlyView., 2022
IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu, Ya Wang, Mina Khoshdeli, Matt Peach, Jen‐Chieh Chuang, Julie Lin, Wen‐Wei Tsai, Sangeetha Mahadevan, Wesley Minto, Lauri Diehl, Ruchi Gupta, Michael Trauner, Keyur Patel, Mazen Noureddin, Kris V. Kowdley, Aliya Gulamhusein, Christopher L. Bowlus, Ryan S. Huss, Robert P. Myers, Chuhan Chung, Andrew N. Billin   +20 more
wiley   +1 more source

Functions of cell surface galectin-glycoprotein lattices [PDF]

, 2007
Programmed remodeling of cell surface glycans by the sequential action of specific glycosyltransferases can control biological processes by generating or masking ligands for endogenous lectins. Galectins, a family of animal lectins with affinity for beta-
Jackson, Shawn S., Rabinovich, Gabriel Adrián, Toscano, Marta Alicia, Vasta, Gerardo R.   +3 more
core   +1 more source