Results 1 to 10 of about 18,149 (205)

Galectins as Checkpoints of the Immune System in Cancers, Their Clinical Relevance, and Implication in Clinical Trials

Biomolecules, 2020
Galectins are small proteins with pleiotropic functions, which depend on both their lectin (glycan recognition) and non-lectin (recognition of other biomolecules besides glycans) interactions.
Daniel Compagno, Carolina Tiraboschi, José Daniel Garcia, Yorfer Rondón, Enrique Corapi, Carla Velazquez, Diego José Laderach   +6 more
doaj   +2 more sources

The Emerging Role of Galectins and O-GlcNAc Homeostasis in Processes of Cellular Differentiation

Cells, 2020
Galectins are a family of soluble β-galactoside-binding proteins with diverse glycan-dependent and glycan-independent functions outside and inside the cell.
Rada Tazhitdinova, Alexander V. Timoshenko   +1 more
doaj   +2 more sources

Les galectines [PDF]

médecine/sciences, 2015
Galectins constitute a family of soluble animal lectins defined by their evolutionary conserved carbohydrate recognition domain and their affinity for β-galactosides containing glycoconjugates. Each galectin is characterized by a specific spatio-temporal distribution and a unique set of ligands and molecular partners. Interestingly, galectins are found
Tamara Advedissian, Frédérique Deshayes, Françoise Poirier, Cyrille Grandjean, Mireille Viguier   +4 more
openaire   +4 more sources

Galectins as self/non-self recognition receptors in innate and adaptive immunity: An unresolved paradox

Frontiers in Immunology, 2012
Galectins are characterized by their binding affinity for ß-galactosides, a unique binding site sequence motif, and wide taxonomic distribution and structural conservation in vertebrates, invertebrates, protista, and fungi.
Gerardo R. Vasta, Hafiz eAhmed, Mihai eNita-Lazar, Aditi eBanerjee, Marta ePasek, Surekha eShridhar, Surekha eShridhar, Prasun eGuha, José A Fernández-Robledo   +8 more
doaj   +1 more source

Regulation of cell adhesion to galectins by glycosylation: A new concept in lymphoma cell adhesion

Advances in Cancer Biology - Metastasis, 2021
To investigate the biological roles of glycosylation in human lymphoma cell adhesion to galectins, I performed the cell adhesion assay using neuraminidase or glycosylation inhibitors on B cell lymphoma cell line.
Osamu Suzuki
doaj   +1 more source

Hepatic stellate cells contribute to liver regeneration through galectins in hepatic stem cell niche

Stem Cell Research & Therapy, 2020
Background As a critical cellular component in the hepatic stem cell niche, hepatic stellate cells (HSCs) play critical roles in regulating the expansion of hepatic stem cells, liver regeneration, and fibrogenesis.
Jian-Yun Ge, Yun-Wen Zheng, Tomonori Tsuchida, Kinji Furuya, Hiroko Isoda, Hideki Taniguchi, Nobuhiro Ohkohchi, Tatsuya Oda   +7 more
doaj   +1 more source

VEGFR1 and VEGFR2 involvement in extracellular galectin-1- and galectin-3-induced angiogenesis. [PDF]

PLoS ONE, 2013
AIM: Accumulating evidence suggests that extracellular galectin-1 and galectin-3 promote angiogenesis. Increased expression of galectin-1 and/or galectin-3 has been reported to be associated with tumour progression. Thus, it is critical to identify their
Nicky D'Haene, Sébastien Sauvage, Calliope Maris, Ivan Adanja, Marie Le Mercier, Christine Decaestecker, Linda Baum, Isabelle Salmon   +7 more
doaj   +1 more source

Multifaceted roles of Galectins: from carbohydrate binding to targeted cancer therapy

Biomarker Research
Galectins play pivotal roles in cellular recognition and signaling processes by interacting with glycoconjugates. Extensive research has highlighted the significance of Galectins in the context of cancer, aiding in the identification of biomarkers for ...
Nan Zhang, Qiao Liu, Daihan Wang, Xiaoyun Wang, Zhaoping Pan, Bo Han, Gu He   +6 more
doaj   +1 more source

Immunobiology of Gestational Diabetes Mellitus in Post-Medawar Era

Frontiers in Immunology, 2022
Although the concepts related to fetal immune tolerance proposed by Sir Peter Medawar in the 1950s have not withstood the test of time, they revolutionized our current understanding of the immunity at the maternal-fetal interface.
Surendra Sharma, Sayani Banerjee, Paula M. Krueger, Sandra M. Blois   +3 more
doaj   +1 more source

Epithelial-derived galectin-9 containing exosomes contribute to the immunomodulatory effects promoted by 2’-fucosyllactose and short-chain galacto- and long-chain fructo-oligosaccharides

Frontiers in Immunology, 2022
IntroductionEarly life exposure to non-digestible oligosaccharides (NDO) or microbial components is known to affect immune development. NDO in combination with a TLR9 agonist mimicking bacterial triggers (CpG) promoted the secretion of galectins through ...
Veronica Ayechu-Muruzabal, Merel de Boer, Bart Blokhuis, Alinda J. Berends, Johan Garssen, Johan Garssen, Aletta D. Kraneveld, Belinda van’t Land, Belinda van’t Land, Linette E. M. Willemsen   +9 more
doaj   +1 more source