Results 131 to 140 of about 18,149 (205)

Beyond PD‐1: Mechanisms of Resistance to Checkpoint Blockade in Classical Hodgkin Lymphoma and Next‐Generation Immune Strategies

European Journal of Haematology, Volume 116, Issue 4, Page 357-367, April 2026.
ABSTRACT PD‐1 inhibitors have reshaped the treatment landscape of classical Hodgkin lymphoma, yet a substantial proportion of patients exhibit primary or acquired resistance driven by tumor‐intrinsic alterations, immunosuppressive microenvironmental signals, metabolic constraints, and EBV‐mediated modulation.
Santino Caserta, Enrica Antonia Martino, Mamdouh Skafi, Maria Eugenia Alvaro, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Ernesto Vigna, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source

Overproduction of 42 Amino Acids Long Amyloid Beta Leads to Activation of Secretory Autophagy and Development of Drusen‐Like Structures Originating From Retinal Pigment Epithelium

The FASEB Journal, Volume 40, Issue 5, 15 March 2026.
The role of 42 amino acids long amyloid beta (Aβ) in the retinal pigment epithelium (RPE) was investigated using 5xFAD mice model overproducing Aβ. The RPE cells of 5xFAD mice showed increased oxidative stress, accumulation of autophagy‐destined proteins, increased expression of secretory autophagy markers, and increase in epithelial‐to‐mesenchymal ...
Johanna Ruuth, Toni Tamminen, Elisa Toropainen, Heikki Tanila, Juha M. T. Hyttinen, Tarja Malm, Kai Kaarniranta, Ali Koskela   +7 more
wiley   +1 more source

Microglial HVCN1 Deficiency Improves Movement and Survival of SOD1G93A ALS Mice by Enhancing Microglial Migration and Neuroprotection

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Hydrogen voltage gated channel 1 (HVCN1) is upregulated in microglia of both ALS patients and its mouse model. HVCN1 deficiency enhances microglial migration via suppressing Akt signaling, promotes neurotrophic capacity and motor function, and prolongs survival of the SOD1G93A ALS mice. This study identifies HVCN1 as a novel, promising druggable target
Fan Wang, Ke‐Yu Zhang, Lang‐Jian Zhu, Wei‐Jue Li, Yang Wu, Xiang Gao, Xiao‐Ru Ma, Xiu‐Hua Yin, Jian‐Bin Wu, Xiao‐Kang Ye, Zhao‐Jun Dong, Di‐Xian Wang, Zhe Zhou, Shao‐Dong Wang, Lei Han, Zhi‐Nong Jiang, Jing‐Wei Zhao   +16 more
wiley   +1 more source

Biomimetic Membrane Interface Technologies for Detection and Isolation of CTCs and EVs: Advances and Opportunities in Liquid Biopsy

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Biomimetic membrane interface engineering constructs functionalized detection platforms by integrating natural cell membranes, synthetic lipids, or hybrid membranes. This strategy effectively reduces background interference and enables efficient target capture and analysis, showing broad applications in circulating tumor cell separation, extracellular ...
Duo Liu, Jie Yu, Jingxue Li, Yixue Chen, Mengle Peng, Yifan Xu, Yongjun Wu, Lihua Ding, Sitian He   +8 more
wiley   +1 more source

Genetic Alterations Involved in Immune Escape Mechanisms of Circulating Tumour Cells in Colorectal Carcinogenesis

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT In colorectal cancer (CRC), circulating tumour cells (CTCs) employ genetic alterations to dodge the body's immune system. These alterations occur in specific “driver” genes, including KRAS, BRAF, p53, MYC, APC and PTEN. Changes in these genes can control how the tumour interacts with the immune system and influence the expression of immune ...
Sharmin Aktar, Matthew Masoudi, Dilpreet Moti, Vinod Gopalan, Farhadul Islam, Alfred King‐yin Lam   +5 more
wiley   +1 more source

Solid Subtype of Papillary Thyroid Carcinoma: A Case Series Highlighting Aggressive Features

Clinical Case Reports, Volume 14, Issue 3, March 2026.
Hematoxylin and eosin (H&E) stained section, 40×. Tumor cells with “Orphan Annie eye” nuclei arranged in solid nests. ABSTRACT Papillary thyroid carcinoma (PTC) is the most common malignant thyroid neoplasm. Its solid/trabecular subtype (STPTC) is rare, and its aggressiveness remains controversial.
Rafael Castellanos Bueno, Gabriela Almeyda Carreño, Diana Carolina Vergara Arenas, Laura Yibeth Esteban Badillo, Ernesto García Ayala   +4 more
wiley   +1 more source

An In‐Depth Evaluation of CD15 Expression in Thyroid Carcinoma: A Comprehensive Systematic Review

Cancer Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Cluster of differentiation 15 (CD15) is a carbohydrate epitope implicated in cell adhesion, migration, and tumor progression. It is variably expressed in thyroid carcinoma (TC) subtypes. However, its diagnostic and prognostic value remains uncertain due to methodological heterogeneity and inconsistent findings. Aim To systematically
Amir Ebrahimzadeh Pasha, Amirhossein Ehsani, Sara Ashtari, Mohammad Sadeq Najafi, Bardia Baik, Mohammad Mahdi Mehrabi   +5 more
wiley   +1 more source

Macrophage‐derived galectin‐3 contributes to pyroptosis, apoptosis and necroptosis through TLR4/MyD88/NF‐κB/NLRP3 during atherosclerosis

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
Pyroptosis, apoptosis and necroptosis of macrophages occur concurrently during atherosclerosis. Galetein‐3 and NLRP3 are highly expressed in atherosclerotic lesions. Galectin‐3 is principally expressed in macrophages within atherosclerotic plaques. Galectin‐3 interacts with NLRP3, activates TLR4/MyD88/NF‐κB/NLRP3 signal axis, and promotes PANoptosis ...
Zihui Yuan, Haitao Li, Bing Xing Ruan, Hongyi Huang, Yiqing Li, Jian Wang   +5 more
wiley   +1 more source

Transcriptome–Proteome Analysis of Human Naive and Memory B Cell Subsets Reveals Isotype and Subclass‐Specific Phenotypes

European Journal of Immunology, Volume 56, Issue 3, March 2026.
We performed combined proteome and transcriptome analysis of human isotype‐defined B cell subsets. IgG4‐switched B cells were most distinct from naive B cells in terms of mRNA as well as protein expression profiles. SDR16C5 was identified as uniquely upregulated in IgG4‐switched B cells.
Jana Koers, Arie J. Hoogendijk, Simon Tol, Floris P.J. Van Alphen, Ninotska I.L. Derksen, Maartje van den Biggelaar, Theo Rispens   +6 more
wiley   +1 more source

TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis.

Developmental Cell, 2016
S. Chauhan, Suresh Kumar, Ashish Jain, Marisa Ponpuak, M. Mudd, Tomonori Kimura, Seong Won Choi, R. Peters, M. Mandell, J. Bruun, T. Johansen, V. Deretic   +11 more
semanticscholar   +1 more source