Results 151 to 160 of about 18,149 (205)

Blood Based Biomarkers for Predicting Treatment Response to Immune Checkpoint Inhibitors After EGFR‐TKI Resistance in Non‐Small Cell Lung Cancer

open access: yesThoracic Cancer, Volume 17, Issue 6, March 2026.
In EGFR‐mutant non‐small cell lung cancer, immune checkpoint inhibitors generally show limited efficacy. By integrating plasma proteomics and tumor immunohistochemistry, we identified biomarkers associated with durable clinical benefit and progression‐free survival following immunotherapy.
Min Seok Park   +15 more
wiley   +1 more source

Secretory autophagy and epithelial‐to‐mesenchymal transition in cadaveric AMD samples: Novel pathways in disease progression

open access: yesActa Ophthalmologica, Volume 104, Issue 2, Page 239-251, March 2026.
Abstract Purpose To examine the presence of secretory autophagy and epithelial–mesenchymal transition (EMT) in the macular retinal pigment epithelium (RPE) of human cadaver eyes with different forms of age‐related macular degeneration (AMD). Methods Human cadaver macula samples representing dry and wet AMD, as well as age‐matched controls, were ...
Iswariyaraja Sridevi Gurubaran   +3 more
wiley   +1 more source

The impact of Foxp3+ regulatory T‐cells on CD8+ T‐cell dysfunction in tumour microenvironments and responses to immune checkpoint inhibitors

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 6, Page 1250-1270, March 2026.
Immune checkpoint inhibitors (ICIs) have been a breakthrough in cancer therapy, inducing durable remissions in responding patients. However, they are associated with variable outcomes, spanning from disease hyperprogression to complete responses with the onset of immune‐related adverse events.
Mikhaël Attias, Ciriaco A. Piccirillo
wiley   +1 more source

Leveraging the ADAM10 prodomain for selective inhibition to enhance recovery after myocardial infarction

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 5, Page 990-1008, March 2026.
Background and Purpose Inflammation plays a crucial role in the development and progression of numerous acute and chronic diseases such as myocardial infarction (MI) and heart failure. Targeting ADAM proteases, particularly ADAM10, holds promise for fine‐tuning inflammatory responses.
Erik Klapproth   +16 more
wiley   +1 more source

Galectin-3 [PDF]

open access: yes, 2017
O. A. Gressner, A. M. Gressner
openaire   +2 more sources

SUSD2 Promotes Metastasis and Primary Tumor Growth in Pancreatic Cancer Cells via Integrin–FAK Signaling Activation

open access: yesCancer Science, Volume 117, Issue 3, Page 711-726, March 2026.
This study investigates the role of Sushi domain‐containing 2 (SUSD2) in pancreatic ductal adenocarcinoma (PDAC) and demonstrates that SUSD2 enhances both metastasis and primary tumor growth by promoting integrin β1–FAK signaling. SUSD2 interacts with integrin β1, enhancing adhesion to extracellular matrix (ECM) components such as collagen 1 and ...
Junjiro Yoshida   +11 more
wiley   +1 more source

Galectin Structure.

open access: yesTrends in Glycoscience and Glycotechnology, 1997
Yuri D. Lobsanov, James M. Rini
openaire   +2 more sources

Clinical, Prognostic, and Biological Features of High‐Risk Cardiometabolic Phenotype: The REMODEL Study

open access: yes
MedComm, Volume 7, Issue 3, March 2026.
Adam A. R. Muhammad   +7 more
wiley   +1 more source

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